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T-cadherin is located in the nucleus and centrosomes in endothelial cells
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| Zeitschriftentitel: | American Journal of Physiology-Cell Physiology |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | American Journal of Physiology-Cell Physiology, 297, 2009, 5, S. C1168-C1177 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Andreeva, Alexandra V. Kutuzov, Mikhail A. Tkachuk, Vsevolod A. Voyno-Yasenetskaya, Tatyana A. Andreeva, Alexandra V. Kutuzov, Mikhail A. Tkachuk, Vsevolod A. Voyno-Yasenetskaya, Tatyana A. |
|---|---|
| author |
Andreeva, Alexandra V. Kutuzov, Mikhail A. Tkachuk, Vsevolod A. Voyno-Yasenetskaya, Tatyana A. |
| spellingShingle |
Andreeva, Alexandra V. Kutuzov, Mikhail A. Tkachuk, Vsevolod A. Voyno-Yasenetskaya, Tatyana A. American Journal of Physiology-Cell Physiology T-cadherin is located in the nucleus and centrosomes in endothelial cells Cell Biology Physiology |
| author_sort |
andreeva, alexandra v. |
| spelling |
Andreeva, Alexandra V. Kutuzov, Mikhail A. Tkachuk, Vsevolod A. Voyno-Yasenetskaya, Tatyana A. 0363-6143 1522-1563 American Physiological Society Cell Biology Physiology http://dx.doi.org/10.1152/ajpcell.00237.2009 <jats:p>T-cadherin (H-cadherin, cadherin 13) is upregulated in vascular proliferative disorders and in tumor-associated neovascularization and is deregulated in many cancers. Unlike canonical cadherins, it lacks transmembrane and intracellular domains and is attached to the plasma membrane via a glycosylphosphatidylinositol anchor. T-cadherin is thought to function in signaling rather than as an adhesion molecule. Some interactive partners of T-cadherin at the plasma membrane have recently been identified. We examined T-cadherin location in human endothelial cells using confocal microscopy and subcellular fractionation. We found that a considerable proportion of T-cadherin is located in the nucleus and in the centrosomes. T-cadherin colocalized with a centrosomal marker γ-tubulin uniformly throughout the cell cycle at least in human umbilical vein endothelial cells. In the telophase, T-cadherin transiently concentrated in the midbody and was apparently degraded. Its overexpression resulted in an increase in the number of multinuclear cells, whereas its downregulation by small interfering RNA led to an increase in the number of cells with multiple centrosomes. These findings indicate that deregulation of T-cadherin in endothelial cells may lead to disturbances in cytokinesis or centrosomal replication.</jats:p> T-cadherin is located in the nucleus and centrosomes in endothelial cells American Journal of Physiology-Cell Physiology |
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American Physiological Society, 2009 |
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| title |
T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_unstemmed |
T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_full |
T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_fullStr |
T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_full_unstemmed |
T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_short |
T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_sort |
t-cadherin is located in the nucleus and centrosomes in endothelial cells |
| topic |
Cell Biology Physiology |
| url |
http://dx.doi.org/10.1152/ajpcell.00237.2009 |
| publishDate |
2009 |
| physical |
C1168-C1177 |
| description |
<jats:p>T-cadherin (H-cadherin, cadherin 13) is upregulated in vascular proliferative disorders and in tumor-associated neovascularization and is deregulated in many cancers. Unlike canonical cadherins, it lacks transmembrane and intracellular domains and is attached to the plasma membrane via a glycosylphosphatidylinositol anchor. T-cadherin is thought to function in signaling rather than as an adhesion molecule. Some interactive partners of T-cadherin at the plasma membrane have recently been identified. We examined T-cadherin location in human endothelial cells using confocal microscopy and subcellular fractionation. We found that a considerable proportion of T-cadherin is located in the nucleus and in the centrosomes. T-cadherin colocalized with a centrosomal marker γ-tubulin uniformly throughout the cell cycle at least in human umbilical vein endothelial cells. In the telophase, T-cadherin transiently concentrated in the midbody and was apparently degraded. Its overexpression resulted in an increase in the number of multinuclear cells, whereas its downregulation by small interfering RNA led to an increase in the number of cells with multiple centrosomes. These findings indicate that deregulation of T-cadherin in endothelial cells may lead to disturbances in cytokinesis or centrosomal replication.</jats:p> |
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| author | Andreeva, Alexandra V., Kutuzov, Mikhail A., Tkachuk, Vsevolod A., Voyno-Yasenetskaya, Tatyana A. |
| author_facet | Andreeva, Alexandra V., Kutuzov, Mikhail A., Tkachuk, Vsevolod A., Voyno-Yasenetskaya, Tatyana A., Andreeva, Alexandra V., Kutuzov, Mikhail A., Tkachuk, Vsevolod A., Voyno-Yasenetskaya, Tatyana A. |
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| description | <jats:p>T-cadherin (H-cadherin, cadherin 13) is upregulated in vascular proliferative disorders and in tumor-associated neovascularization and is deregulated in many cancers. Unlike canonical cadherins, it lacks transmembrane and intracellular domains and is attached to the plasma membrane via a glycosylphosphatidylinositol anchor. T-cadherin is thought to function in signaling rather than as an adhesion molecule. Some interactive partners of T-cadherin at the plasma membrane have recently been identified. We examined T-cadherin location in human endothelial cells using confocal microscopy and subcellular fractionation. We found that a considerable proportion of T-cadherin is located in the nucleus and in the centrosomes. T-cadherin colocalized with a centrosomal marker γ-tubulin uniformly throughout the cell cycle at least in human umbilical vein endothelial cells. In the telophase, T-cadherin transiently concentrated in the midbody and was apparently degraded. Its overexpression resulted in an increase in the number of multinuclear cells, whereas its downregulation by small interfering RNA led to an increase in the number of cells with multiple centrosomes. These findings indicate that deregulation of T-cadherin in endothelial cells may lead to disturbances in cytokinesis or centrosomal replication.</jats:p> |
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| spelling | Andreeva, Alexandra V. Kutuzov, Mikhail A. Tkachuk, Vsevolod A. Voyno-Yasenetskaya, Tatyana A. 0363-6143 1522-1563 American Physiological Society Cell Biology Physiology http://dx.doi.org/10.1152/ajpcell.00237.2009 <jats:p>T-cadherin (H-cadherin, cadherin 13) is upregulated in vascular proliferative disorders and in tumor-associated neovascularization and is deregulated in many cancers. Unlike canonical cadherins, it lacks transmembrane and intracellular domains and is attached to the plasma membrane via a glycosylphosphatidylinositol anchor. T-cadherin is thought to function in signaling rather than as an adhesion molecule. Some interactive partners of T-cadherin at the plasma membrane have recently been identified. We examined T-cadherin location in human endothelial cells using confocal microscopy and subcellular fractionation. We found that a considerable proportion of T-cadherin is located in the nucleus and in the centrosomes. T-cadherin colocalized with a centrosomal marker γ-tubulin uniformly throughout the cell cycle at least in human umbilical vein endothelial cells. In the telophase, T-cadherin transiently concentrated in the midbody and was apparently degraded. Its overexpression resulted in an increase in the number of multinuclear cells, whereas its downregulation by small interfering RNA led to an increase in the number of cells with multiple centrosomes. These findings indicate that deregulation of T-cadherin in endothelial cells may lead to disturbances in cytokinesis or centrosomal replication.</jats:p> T-cadherin is located in the nucleus and centrosomes in endothelial cells American Journal of Physiology-Cell Physiology |
| spellingShingle | Andreeva, Alexandra V., Kutuzov, Mikhail A., Tkachuk, Vsevolod A., Voyno-Yasenetskaya, Tatyana A., American Journal of Physiology-Cell Physiology, T-cadherin is located in the nucleus and centrosomes in endothelial cells, Cell Biology, Physiology |
| title | T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_full | T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_fullStr | T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_full_unstemmed | T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_short | T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_sort | t-cadherin is located in the nucleus and centrosomes in endothelial cells |
| title_unstemmed | T-cadherin is located in the nucleus and centrosomes in endothelial cells |
| topic | Cell Biology, Physiology |
| url | http://dx.doi.org/10.1152/ajpcell.00237.2009 |