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Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles
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Zeitschriftentitel: | Chemical Science |
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Personen und Körperschaften: | , , , , , , , , , , , , |
In: | Chemical Science, 10, 2019, 26, S. 6457-6466 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Royal Society of Chemistry (RSC)
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Schlagwörter: |
author_facet |
Yuen, Tsz Ying Brown, Christopher J. Xue, Yuezhen Tan, Yaw Sing Ferrer Gago, Fernando J. Lee, Xue Er Neo, Jin Yong Thean, Dawn Kaan, Hung Yi Kristal Partridge, Anthony W. Verma, Chandra S. Lane, David P. Johannes, Charles W. Yuen, Tsz Ying Brown, Christopher J. Xue, Yuezhen Tan, Yaw Sing Ferrer Gago, Fernando J. Lee, Xue Er Neo, Jin Yong Thean, Dawn Kaan, Hung Yi Kristal Partridge, Anthony W. Verma, Chandra S. Lane, David P. Johannes, Charles W. |
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author |
Yuen, Tsz Ying Brown, Christopher J. Xue, Yuezhen Tan, Yaw Sing Ferrer Gago, Fernando J. Lee, Xue Er Neo, Jin Yong Thean, Dawn Kaan, Hung Yi Kristal Partridge, Anthony W. Verma, Chandra S. Lane, David P. Johannes, Charles W. |
spellingShingle |
Yuen, Tsz Ying Brown, Christopher J. Xue, Yuezhen Tan, Yaw Sing Ferrer Gago, Fernando J. Lee, Xue Er Neo, Jin Yong Thean, Dawn Kaan, Hung Yi Kristal Partridge, Anthony W. Verma, Chandra S. Lane, David P. Johannes, Charles W. Chemical Science Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles General Chemistry |
author_sort |
yuen, tsz ying |
spelling |
Yuen, Tsz Ying Brown, Christopher J. Xue, Yuezhen Tan, Yaw Sing Ferrer Gago, Fernando J. Lee, Xue Er Neo, Jin Yong Thean, Dawn Kaan, Hung Yi Kristal Partridge, Anthony W. Verma, Chandra S. Lane, David P. Johannes, Charles W. 2041-6520 2041-6539 Royal Society of Chemistry (RSC) General Chemistry http://dx.doi.org/10.1039/c9sc01456j <p>Staple composition can influence target binding and bioactivity of peptides. We present strategies to modulate<italic>E</italic>/<italic>Z</italic>ratios and access saturated analogues.</p> Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles Chemical Science |
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Royal Society of Chemistry (RSC), 2019 |
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title |
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_unstemmed |
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_full |
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_fullStr |
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_full_unstemmed |
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_short |
Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_sort |
stereoisomerism of stapled peptide inhibitors of the p53-mdm2 interaction: an assessment of synthetic strategies and activity profiles |
topic |
General Chemistry |
url |
http://dx.doi.org/10.1039/c9sc01456j |
publishDate |
2019 |
physical |
6457-6466 |
description |
<p>Staple composition can influence target binding and bioactivity of peptides. We present strategies to modulate<italic>E</italic>/<italic>Z</italic>ratios and access saturated analogues.</p> |
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author | Yuen, Tsz Ying, Brown, Christopher J., Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J., Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W., Verma, Chandra S., Lane, David P., Johannes, Charles W. |
author_facet | Yuen, Tsz Ying, Brown, Christopher J., Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J., Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W., Verma, Chandra S., Lane, David P., Johannes, Charles W., Yuen, Tsz Ying, Brown, Christopher J., Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J., Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W., Verma, Chandra S., Lane, David P., Johannes, Charles W. |
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description | <p>Staple composition can influence target binding and bioactivity of peptides. We present strategies to modulate<italic>E</italic>/<italic>Z</italic>ratios and access saturated analogues.</p> |
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series | Chemical Science |
source_id | 49 |
spelling | Yuen, Tsz Ying Brown, Christopher J. Xue, Yuezhen Tan, Yaw Sing Ferrer Gago, Fernando J. Lee, Xue Er Neo, Jin Yong Thean, Dawn Kaan, Hung Yi Kristal Partridge, Anthony W. Verma, Chandra S. Lane, David P. Johannes, Charles W. 2041-6520 2041-6539 Royal Society of Chemistry (RSC) General Chemistry http://dx.doi.org/10.1039/c9sc01456j <p>Staple composition can influence target binding and bioactivity of peptides. We present strategies to modulate<italic>E</italic>/<italic>Z</italic>ratios and access saturated analogues.</p> Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles Chemical Science |
spellingShingle | Yuen, Tsz Ying, Brown, Christopher J., Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J., Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W., Verma, Chandra S., Lane, David P., Johannes, Charles W., Chemical Science, Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles, General Chemistry |
title | Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_full | Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_fullStr | Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_full_unstemmed | Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_short | Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_sort | stereoisomerism of stapled peptide inhibitors of the p53-mdm2 interaction: an assessment of synthetic strategies and activity profiles |
title_unstemmed | Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles |
topic | General Chemistry |
url | http://dx.doi.org/10.1039/c9sc01456j |