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Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells
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| Zeitschriftentitel: | Scientific Reports |
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| Personen und Körperschaften: | , , , , , , , , , |
| In: | Scientific Reports, 8, 2018, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Springer Science and Business Media LLC
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| Schlagwörter: |
| author_facet |
Song, Anping Zhu, Ling Gorantla, Gowthami Berdysz, Olimpia Amici, Stephanie A. Guerau-de-Arellano, Mireia Madalena, Kathryn M. Lerch, Jessica K. Liu, Xiaoyu Quan, Ning Song, Anping Zhu, Ling Gorantla, Gowthami Berdysz, Olimpia Amici, Stephanie A. Guerau-de-Arellano, Mireia Madalena, Kathryn M. Lerch, Jessica K. Liu, Xiaoyu Quan, Ning |
|---|---|
| author |
Song, Anping Zhu, Ling Gorantla, Gowthami Berdysz, Olimpia Amici, Stephanie A. Guerau-de-Arellano, Mireia Madalena, Kathryn M. Lerch, Jessica K. Liu, Xiaoyu Quan, Ning |
| spellingShingle |
Song, Anping Zhu, Ling Gorantla, Gowthami Berdysz, Olimpia Amici, Stephanie A. Guerau-de-Arellano, Mireia Madalena, Kathryn M. Lerch, Jessica K. Liu, Xiaoyu Quan, Ning Scientific Reports Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells Multidisciplinary |
| author_sort |
song, anping |
| spelling |
Song, Anping Zhu, Ling Gorantla, Gowthami Berdysz, Olimpia Amici, Stephanie A. Guerau-de-Arellano, Mireia Madalena, Kathryn M. Lerch, Jessica K. Liu, Xiaoyu Quan, Ning 2045-2322 Springer Science and Business Media LLC Multidisciplinary http://dx.doi.org/10.1038/s41598-018-19248-7 <jats:title>Abstract</jats:title><jats:p>Interleukin 1 is a pleiotropic cytokine that mediates diverse functions through its receptor, type I interleukin 1 receptor (IL-1R1). Most previous studies have focused on the expression and function of IL-1R1 in immune cells. Here we performed a comprehensive mapping of IL-1R1 distribution in multiple peripheral tissues using our IL-1R1 reporter (IL-1R1<jats:sup>GR/GR</jats:sup>) mice. This method yielded the highest sensitivity of<jats:italic>in situ</jats:italic>detection of IL-1R1 mRNA and protein. Besides validating previously reported IL-1R1 expression in the endocrine tissues including pituitary and pancreas, our results refuted previously reported exclusive IL-1R1 expression in neurons of the spinal cord dorsal horn and dorsal root ganglia (DRG). Instead, IL-1R1 expression was detected in endothelial cells within DRG, spinal cord, pancreas, colon, muscles and many immune organs. In addition, gp38<jats:sup>+</jats:sup>fibroblastic reticular cells (FRCs), rather than tissue macrophages or other immune cells, were found to express high levels of IL-1R1 in colon and many immune organs. A functional test of spleen FRCs showed that they responded rapidly to systemic IL-1β stimulation<jats:italic>in vivo</jats:italic>. Taken together, this study provides a rigorous re-examination of IL-1R1 expression in peripheral tissues and reveals tissue FRCs as a previously unappreciated novel high IL-1R1-expressing cell type in peripheral IL-1 signaling.</jats:p> Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells Scientific Reports |
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| title |
Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_unstemmed |
Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_full |
Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_fullStr |
Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_full_unstemmed |
Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_short |
Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_sort |
salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
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Multidisciplinary |
| url |
http://dx.doi.org/10.1038/s41598-018-19248-7 |
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2018 |
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<jats:title>Abstract</jats:title><jats:p>Interleukin 1 is a pleiotropic cytokine that mediates diverse functions through its receptor, type I interleukin 1 receptor (IL-1R1). Most previous studies have focused on the expression and function of IL-1R1 in immune cells. Here we performed a comprehensive mapping of IL-1R1 distribution in multiple peripheral tissues using our IL-1R1 reporter (IL-1R1<jats:sup>GR/GR</jats:sup>) mice. This method yielded the highest sensitivity of<jats:italic>in situ</jats:italic>detection of IL-1R1 mRNA and protein. Besides validating previously reported IL-1R1 expression in the endocrine tissues including pituitary and pancreas, our results refuted previously reported exclusive IL-1R1 expression in neurons of the spinal cord dorsal horn and dorsal root ganglia (DRG). Instead, IL-1R1 expression was detected in endothelial cells within DRG, spinal cord, pancreas, colon, muscles and many immune organs. In addition, gp38<jats:sup>+</jats:sup>fibroblastic reticular cells (FRCs), rather than tissue macrophages or other immune cells, were found to express high levels of IL-1R1 in colon and many immune organs. A functional test of spleen FRCs showed that they responded rapidly to systemic IL-1β stimulation<jats:italic>in vivo</jats:italic>. Taken together, this study provides a rigorous re-examination of IL-1R1 expression in peripheral tissues and reveals tissue FRCs as a previously unappreciated novel high IL-1R1-expressing cell type in peripheral IL-1 signaling.</jats:p> |
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| author | Song, Anping, Zhu, Ling, Gorantla, Gowthami, Berdysz, Olimpia, Amici, Stephanie A., Guerau-de-Arellano, Mireia, Madalena, Kathryn M., Lerch, Jessica K., Liu, Xiaoyu, Quan, Ning |
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| description | <jats:title>Abstract</jats:title><jats:p>Interleukin 1 is a pleiotropic cytokine that mediates diverse functions through its receptor, type I interleukin 1 receptor (IL-1R1). Most previous studies have focused on the expression and function of IL-1R1 in immune cells. Here we performed a comprehensive mapping of IL-1R1 distribution in multiple peripheral tissues using our IL-1R1 reporter (IL-1R1<jats:sup>GR/GR</jats:sup>) mice. This method yielded the highest sensitivity of<jats:italic>in situ</jats:italic>detection of IL-1R1 mRNA and protein. Besides validating previously reported IL-1R1 expression in the endocrine tissues including pituitary and pancreas, our results refuted previously reported exclusive IL-1R1 expression in neurons of the spinal cord dorsal horn and dorsal root ganglia (DRG). Instead, IL-1R1 expression was detected in endothelial cells within DRG, spinal cord, pancreas, colon, muscles and many immune organs. In addition, gp38<jats:sup>+</jats:sup>fibroblastic reticular cells (FRCs), rather than tissue macrophages or other immune cells, were found to express high levels of IL-1R1 in colon and many immune organs. A functional test of spleen FRCs showed that they responded rapidly to systemic IL-1β stimulation<jats:italic>in vivo</jats:italic>. Taken together, this study provides a rigorous re-examination of IL-1R1 expression in peripheral tissues and reveals tissue FRCs as a previously unappreciated novel high IL-1R1-expressing cell type in peripheral IL-1 signaling.</jats:p> |
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| spelling | Song, Anping Zhu, Ling Gorantla, Gowthami Berdysz, Olimpia Amici, Stephanie A. Guerau-de-Arellano, Mireia Madalena, Kathryn M. Lerch, Jessica K. Liu, Xiaoyu Quan, Ning 2045-2322 Springer Science and Business Media LLC Multidisciplinary http://dx.doi.org/10.1038/s41598-018-19248-7 <jats:title>Abstract</jats:title><jats:p>Interleukin 1 is a pleiotropic cytokine that mediates diverse functions through its receptor, type I interleukin 1 receptor (IL-1R1). Most previous studies have focused on the expression and function of IL-1R1 in immune cells. Here we performed a comprehensive mapping of IL-1R1 distribution in multiple peripheral tissues using our IL-1R1 reporter (IL-1R1<jats:sup>GR/GR</jats:sup>) mice. This method yielded the highest sensitivity of<jats:italic>in situ</jats:italic>detection of IL-1R1 mRNA and protein. Besides validating previously reported IL-1R1 expression in the endocrine tissues including pituitary and pancreas, our results refuted previously reported exclusive IL-1R1 expression in neurons of the spinal cord dorsal horn and dorsal root ganglia (DRG). Instead, IL-1R1 expression was detected in endothelial cells within DRG, spinal cord, pancreas, colon, muscles and many immune organs. In addition, gp38<jats:sup>+</jats:sup>fibroblastic reticular cells (FRCs), rather than tissue macrophages or other immune cells, were found to express high levels of IL-1R1 in colon and many immune organs. A functional test of spleen FRCs showed that they responded rapidly to systemic IL-1β stimulation<jats:italic>in vivo</jats:italic>. Taken together, this study provides a rigorous re-examination of IL-1R1 expression in peripheral tissues and reveals tissue FRCs as a previously unappreciated novel high IL-1R1-expressing cell type in peripheral IL-1 signaling.</jats:p> Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells Scientific Reports |
| spellingShingle | Song, Anping, Zhu, Ling, Gorantla, Gowthami, Berdysz, Olimpia, Amici, Stephanie A., Guerau-de-Arellano, Mireia, Madalena, Kathryn M., Lerch, Jessica K., Liu, Xiaoyu, Quan, Ning, Scientific Reports, Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells, Multidisciplinary |
| title | Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_full | Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_fullStr | Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_full_unstemmed | Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_short | Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_sort | salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| title_unstemmed | Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1038/s41598-018-19248-7 |