Eintrag weiter verarbeiten
The role of EZH2 in overall survival of colorectal cancer: a meta-analysis
Gespeichert in:
Zeitschriftentitel: | Scientific Reports |
---|---|
Personen und Körperschaften: | , , , , , , , |
In: | Scientific Reports, 7, 2017, 1 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Springer Science and Business Media LLC
|
Schlagwörter: |
author_facet |
Vilorio-Marqués, Laura Martín, Vicente Diez-Tascón, Cristina González-Sevilla, María Francisca Fernández-Villa, Tania Honrado, Emiliano Davila-Batista, Veronica Molina, Antonio J. Vilorio-Marqués, Laura Martín, Vicente Diez-Tascón, Cristina González-Sevilla, María Francisca Fernández-Villa, Tania Honrado, Emiliano Davila-Batista, Veronica Molina, Antonio J. |
---|---|
author |
Vilorio-Marqués, Laura Martín, Vicente Diez-Tascón, Cristina González-Sevilla, María Francisca Fernández-Villa, Tania Honrado, Emiliano Davila-Batista, Veronica Molina, Antonio J. |
spellingShingle |
Vilorio-Marqués, Laura Martín, Vicente Diez-Tascón, Cristina González-Sevilla, María Francisca Fernández-Villa, Tania Honrado, Emiliano Davila-Batista, Veronica Molina, Antonio J. Scientific Reports The role of EZH2 in overall survival of colorectal cancer: a meta-analysis Multidisciplinary |
author_sort |
vilorio-marqués, laura |
spelling |
Vilorio-Marqués, Laura Martín, Vicente Diez-Tascón, Cristina González-Sevilla, María Francisca Fernández-Villa, Tania Honrado, Emiliano Davila-Batista, Veronica Molina, Antonio J. 2045-2322 Springer Science and Business Media LLC Multidisciplinary http://dx.doi.org/10.1038/s41598-017-13670-z <jats:title>Abstract</jats:title><jats:p>Enhancer of zeste homolog 2 (EZH2) is the catalitic subunit of polycomb repressive complex 2 and mediates gene silencing. EZH2 is overexpressed in many cancers and correlates with poor prognosis. The role of the gene EZH2 in colorectal cancer survival is uncertainly, the aim of this study is clear this relationship. Relevant literaure was searched from electronic databases. A meta-analysis was performed with elegible studies which quantitatively evaluated the relationship between EZH2 overexpression and survival of patients with colorectal cancer. Survival data were aggregated and quantitatively analyzed. We performed a meta-analysis of 8 studies (n = 1059 patients) that evaluated the correlation between EZH2 overexpression and survival in patients with colorectal cancer. Combined hazard ratios suggested that EZH2 overexpression was associated with better prognosis of overall survival (OS) HR(hazard ratio) = 0.61 95% CI (0.38–0.84) We performed bias analysis according Egger and Begg,s test and we did not find publication bias. EZH2 overexpression indicates a better prognosis for colorectal cancer.</jats:p> The role of EZH2 in overall survival of colorectal cancer: a meta-analysis Scientific Reports |
doi_str_mv |
10.1038/s41598-017-13670-z |
facet_avail |
Online Free |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAzOC9zNDE1OTgtMDE3LTEzNjcwLXo |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAzOC9zNDE1OTgtMDE3LTEzNjcwLXo |
institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
imprint |
Springer Science and Business Media LLC, 2017 |
imprint_str_mv |
Springer Science and Business Media LLC, 2017 |
issn |
2045-2322 |
issn_str_mv |
2045-2322 |
language |
English |
mega_collection |
Springer Science and Business Media LLC (CrossRef) |
match_str |
viloriomarques2017theroleofezh2inoverallsurvivalofcolorectalcancerametaanalysis |
publishDateSort |
2017 |
publisher |
Springer Science and Business Media LLC |
recordtype |
ai |
record_format |
ai |
series |
Scientific Reports |
source_id |
49 |
title |
The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_unstemmed |
The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_full |
The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_fullStr |
The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_full_unstemmed |
The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_short |
The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_sort |
the role of ezh2 in overall survival of colorectal cancer: a meta-analysis |
topic |
Multidisciplinary |
url |
http://dx.doi.org/10.1038/s41598-017-13670-z |
publishDate |
2017 |
physical |
|
description |
<jats:title>Abstract</jats:title><jats:p>Enhancer of zeste homolog 2 (EZH2) is the catalitic subunit of polycomb repressive complex 2 and mediates gene silencing. EZH2 is overexpressed in many cancers and correlates with poor prognosis. The role of the gene EZH2 in colorectal cancer survival is uncertainly, the aim of this study is clear this relationship. Relevant literaure was searched from electronic databases. A meta-analysis was performed with elegible studies which quantitatively evaluated the relationship between EZH2 overexpression and survival of patients with colorectal cancer. Survival data were aggregated and quantitatively analyzed. We performed a meta-analysis of 8 studies (n = 1059 patients) that evaluated the correlation between EZH2 overexpression and survival in patients with colorectal cancer. Combined hazard ratios suggested that EZH2 overexpression was associated with better prognosis of overall survival (OS) HR(hazard ratio) = 0.61 95% CI (0.38–0.84) We performed bias analysis according Egger and Begg,s test and we did not find publication bias. EZH2 overexpression indicates a better prognosis for colorectal cancer.</jats:p> |
container_issue |
1 |
container_start_page |
0 |
container_title |
Scientific Reports |
container_volume |
7 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792342369720336388 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T16:34:42.448Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=The+role+of+EZH2+in+overall+survival+of+colorectal+cancer%3A+a+meta-analysis&rft.date=2017-10-23&genre=article&issn=2045-2322&volume=7&issue=1&jtitle=Scientific+Reports&atitle=The+role+of+EZH2+in+overall+survival+of+colorectal+cancer%3A+a+meta-analysis&aulast=Molina&aufirst=Antonio+J.&rft_id=info%3Adoi%2F10.1038%2Fs41598-017-13670-z&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792342369720336388 |
author | Vilorio-Marqués, Laura, Martín, Vicente, Diez-Tascón, Cristina, González-Sevilla, María Francisca, Fernández-Villa, Tania, Honrado, Emiliano, Davila-Batista, Veronica, Molina, Antonio J. |
author_facet | Vilorio-Marqués, Laura, Martín, Vicente, Diez-Tascón, Cristina, González-Sevilla, María Francisca, Fernández-Villa, Tania, Honrado, Emiliano, Davila-Batista, Veronica, Molina, Antonio J., Vilorio-Marqués, Laura, Martín, Vicente, Diez-Tascón, Cristina, González-Sevilla, María Francisca, Fernández-Villa, Tania, Honrado, Emiliano, Davila-Batista, Veronica, Molina, Antonio J. |
author_sort | vilorio-marqués, laura |
container_issue | 1 |
container_start_page | 0 |
container_title | Scientific Reports |
container_volume | 7 |
description | <jats:title>Abstract</jats:title><jats:p>Enhancer of zeste homolog 2 (EZH2) is the catalitic subunit of polycomb repressive complex 2 and mediates gene silencing. EZH2 is overexpressed in many cancers and correlates with poor prognosis. The role of the gene EZH2 in colorectal cancer survival is uncertainly, the aim of this study is clear this relationship. Relevant literaure was searched from electronic databases. A meta-analysis was performed with elegible studies which quantitatively evaluated the relationship between EZH2 overexpression and survival of patients with colorectal cancer. Survival data were aggregated and quantitatively analyzed. We performed a meta-analysis of 8 studies (n = 1059 patients) that evaluated the correlation between EZH2 overexpression and survival in patients with colorectal cancer. Combined hazard ratios suggested that EZH2 overexpression was associated with better prognosis of overall survival (OS) HR(hazard ratio) = 0.61 95% CI (0.38–0.84) We performed bias analysis according Egger and Begg,s test and we did not find publication bias. EZH2 overexpression indicates a better prognosis for colorectal cancer.</jats:p> |
doi_str_mv | 10.1038/s41598-017-13670-z |
facet_avail | Online, Free |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAzOC9zNDE1OTgtMDE3LTEzNjcwLXo |
imprint | Springer Science and Business Media LLC, 2017 |
imprint_str_mv | Springer Science and Business Media LLC, 2017 |
institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
issn | 2045-2322 |
issn_str_mv | 2045-2322 |
language | English |
last_indexed | 2024-03-01T16:34:42.448Z |
match_str | viloriomarques2017theroleofezh2inoverallsurvivalofcolorectalcancerametaanalysis |
mega_collection | Springer Science and Business Media LLC (CrossRef) |
physical | |
publishDate | 2017 |
publishDateSort | 2017 |
publisher | Springer Science and Business Media LLC |
record_format | ai |
recordtype | ai |
series | Scientific Reports |
source_id | 49 |
spelling | Vilorio-Marqués, Laura Martín, Vicente Diez-Tascón, Cristina González-Sevilla, María Francisca Fernández-Villa, Tania Honrado, Emiliano Davila-Batista, Veronica Molina, Antonio J. 2045-2322 Springer Science and Business Media LLC Multidisciplinary http://dx.doi.org/10.1038/s41598-017-13670-z <jats:title>Abstract</jats:title><jats:p>Enhancer of zeste homolog 2 (EZH2) is the catalitic subunit of polycomb repressive complex 2 and mediates gene silencing. EZH2 is overexpressed in many cancers and correlates with poor prognosis. The role of the gene EZH2 in colorectal cancer survival is uncertainly, the aim of this study is clear this relationship. Relevant literaure was searched from electronic databases. A meta-analysis was performed with elegible studies which quantitatively evaluated the relationship between EZH2 overexpression and survival of patients with colorectal cancer. Survival data were aggregated and quantitatively analyzed. We performed a meta-analysis of 8 studies (n = 1059 patients) that evaluated the correlation between EZH2 overexpression and survival in patients with colorectal cancer. Combined hazard ratios suggested that EZH2 overexpression was associated with better prognosis of overall survival (OS) HR(hazard ratio) = 0.61 95% CI (0.38–0.84) We performed bias analysis according Egger and Begg,s test and we did not find publication bias. EZH2 overexpression indicates a better prognosis for colorectal cancer.</jats:p> The role of EZH2 in overall survival of colorectal cancer: a meta-analysis Scientific Reports |
spellingShingle | Vilorio-Marqués, Laura, Martín, Vicente, Diez-Tascón, Cristina, González-Sevilla, María Francisca, Fernández-Villa, Tania, Honrado, Emiliano, Davila-Batista, Veronica, Molina, Antonio J., Scientific Reports, The role of EZH2 in overall survival of colorectal cancer: a meta-analysis, Multidisciplinary |
title | The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_full | The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_fullStr | The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_full_unstemmed | The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_short | The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
title_sort | the role of ezh2 in overall survival of colorectal cancer: a meta-analysis |
title_unstemmed | The role of EZH2 in overall survival of colorectal cancer: a meta-analysis |
topic | Multidisciplinary |
url | http://dx.doi.org/10.1038/s41598-017-13670-z |