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GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell
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| Zeitschriftentitel: | Cell Death Discovery |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Cell Death Discovery, 5, 2019, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Springer Science and Business Media LLC
|
| Schlagwörter: |
| author_facet |
Wang, Shaojun Du, Lu Peng, Guanghua Li, Wei Wang, Shaojun Du, Lu Peng, Guanghua Li, Wei |
|---|---|
| author |
Wang, Shaojun Du, Lu Peng, Guanghua Li, Wei |
| spellingShingle |
Wang, Shaojun Du, Lu Peng, Guanghua Li, Wei Cell Death Discovery GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell Cancer Research Cell Biology Cellular and Molecular Neuroscience Immunology |
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wang, shaojun |
| spelling |
Wang, Shaojun Du, Lu Peng, Guanghua Li, Wei 2058-7716 Springer Science and Business Media LLC Cancer Research Cell Biology Cellular and Molecular Neuroscience Immunology http://dx.doi.org/10.1038/s41420-019-0160-z <jats:title>Abstract</jats:title><jats:p>Gamma-amino butyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, including the retina, and play an important role in both regulating neurogenesis and neural stem cell proliferation. GABAa receptor has been identified in the retina, however, the function of GABAa receptor on retinal progenitor cell (RPC) is unclear. RPCs were cultured to analyze changes in cell proliferation and cell cycle distribution after GABAa receptor activation. The activation of GABAa receptor significantly inhibits RPCs proliferation, cell cycle progress, and self-renewal. Moreover, the activation of GABAa receptor leads to the up-expression of p21 and p27 and down-expression of Nestin, Pax6, Sox2, and Chx10. These results suggest that GABA acts as a negative regulator of RPCs proliferation and self-renewal.</jats:p> GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell Cell Death Discovery |
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| title |
GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_unstemmed |
GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_full |
GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_fullStr |
GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_full_unstemmed |
GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_short |
GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_sort |
gaba inhibits proliferation and self-renewal of mouse retinal progenitor cell |
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Cancer Research Cell Biology Cellular and Molecular Neuroscience Immunology |
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http://dx.doi.org/10.1038/s41420-019-0160-z |
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2019 |
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<jats:title>Abstract</jats:title><jats:p>Gamma-amino butyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, including the retina, and play an important role in both regulating neurogenesis and neural stem cell proliferation. GABAa receptor has been identified in the retina, however, the function of GABAa receptor on retinal progenitor cell (RPC) is unclear. RPCs were cultured to analyze changes in cell proliferation and cell cycle distribution after GABAa receptor activation. The activation of GABAa receptor significantly inhibits RPCs proliferation, cell cycle progress, and self-renewal. Moreover, the activation of GABAa receptor leads to the up-expression of p21 and p27 and down-expression of Nestin, Pax6, Sox2, and Chx10. These results suggest that GABA acts as a negative regulator of RPCs proliferation and self-renewal.</jats:p> |
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| author | Wang, Shaojun, Du, Lu, Peng, Guanghua, Li, Wei |
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| description | <jats:title>Abstract</jats:title><jats:p>Gamma-amino butyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, including the retina, and play an important role in both regulating neurogenesis and neural stem cell proliferation. GABAa receptor has been identified in the retina, however, the function of GABAa receptor on retinal progenitor cell (RPC) is unclear. RPCs were cultured to analyze changes in cell proliferation and cell cycle distribution after GABAa receptor activation. The activation of GABAa receptor significantly inhibits RPCs proliferation, cell cycle progress, and self-renewal. Moreover, the activation of GABAa receptor leads to the up-expression of p21 and p27 and down-expression of Nestin, Pax6, Sox2, and Chx10. These results suggest that GABA acts as a negative regulator of RPCs proliferation and self-renewal.</jats:p> |
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| spelling | Wang, Shaojun Du, Lu Peng, Guanghua Li, Wei 2058-7716 Springer Science and Business Media LLC Cancer Research Cell Biology Cellular and Molecular Neuroscience Immunology http://dx.doi.org/10.1038/s41420-019-0160-z <jats:title>Abstract</jats:title><jats:p>Gamma-amino butyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, including the retina, and play an important role in both regulating neurogenesis and neural stem cell proliferation. GABAa receptor has been identified in the retina, however, the function of GABAa receptor on retinal progenitor cell (RPC) is unclear. RPCs were cultured to analyze changes in cell proliferation and cell cycle distribution after GABAa receptor activation. The activation of GABAa receptor significantly inhibits RPCs proliferation, cell cycle progress, and self-renewal. Moreover, the activation of GABAa receptor leads to the up-expression of p21 and p27 and down-expression of Nestin, Pax6, Sox2, and Chx10. These results suggest that GABA acts as a negative regulator of RPCs proliferation and self-renewal.</jats:p> GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell Cell Death Discovery |
| spellingShingle | Wang, Shaojun, Du, Lu, Peng, Guanghua, Li, Wei, Cell Death Discovery, GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell, Cancer Research, Cell Biology, Cellular and Molecular Neuroscience, Immunology |
| title | GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_full | GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_fullStr | GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_full_unstemmed | GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_short | GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_sort | gaba inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| title_unstemmed | GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell |
| topic | Cancer Research, Cell Biology, Cellular and Molecular Neuroscience, Immunology |
| url | http://dx.doi.org/10.1038/s41420-019-0160-z |