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Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study
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| Zeitschriftentitel: | Journal of Cerebral Blood Flow & Metabolism |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , |
| In: | Journal of Cerebral Blood Flow & Metabolism, 35, 2015, 4, S. 554-564 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Auer, Matthias K Sack, Markus Lenz, Jenny N Jakovcevski, Mira Biedermann, Sarah V Falfán-Melgoza, Claudia Deussing, Jan Steinle, Jörg Bielohuby, Maximilian Bidlingmaier, Martin Pfister, Frederik Stalla, Günter K Ende, Gabriele Weber-Fahr, Wolfgang Fuss, Johannes Gass, Peter Auer, Matthias K Sack, Markus Lenz, Jenny N Jakovcevski, Mira Biedermann, Sarah V Falfán-Melgoza, Claudia Deussing, Jan Steinle, Jörg Bielohuby, Maximilian Bidlingmaier, Martin Pfister, Frederik Stalla, Günter K Ende, Gabriele Weber-Fahr, Wolfgang Fuss, Johannes Gass, Peter |
|---|---|
| author |
Auer, Matthias K Sack, Markus Lenz, Jenny N Jakovcevski, Mira Biedermann, Sarah V Falfán-Melgoza, Claudia Deussing, Jan Steinle, Jörg Bielohuby, Maximilian Bidlingmaier, Martin Pfister, Frederik Stalla, Günter K Ende, Gabriele Weber-Fahr, Wolfgang Fuss, Johannes Gass, Peter |
| spellingShingle |
Auer, Matthias K Sack, Markus Lenz, Jenny N Jakovcevski, Mira Biedermann, Sarah V Falfán-Melgoza, Claudia Deussing, Jan Steinle, Jörg Bielohuby, Maximilian Bidlingmaier, Martin Pfister, Frederik Stalla, Günter K Ende, Gabriele Weber-Fahr, Wolfgang Fuss, Johannes Gass, Peter Journal of Cerebral Blood Flow & Metabolism Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology |
| author_sort |
auer, matthias k |
| spelling |
Auer, Matthias K Sack, Markus Lenz, Jenny N Jakovcevski, Mira Biedermann, Sarah V Falfán-Melgoza, Claudia Deussing, Jan Steinle, Jörg Bielohuby, Maximilian Bidlingmaier, Martin Pfister, Frederik Stalla, Günter K Ende, Gabriele Weber-Fahr, Wolfgang Fuss, Johannes Gass, Peter 0271-678X 1559-7016 SAGE Publications Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology http://dx.doi.org/10.1038/jcbfm.2014.231 <jats:p> Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS). It has been suggested that one mechanism in this context is the promotion of neuroinflammation. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating the effects of physical exercise in a cafeteria-diet mouse model on CNS metabolites by means of in vivo proton magnetic resonance spectroscopy (<jats:sup>1</jats:sup>HMRS). In addition postmortem histologic and real-time (RT)-PCR analyses for inflammatory markers were performed. Cafeteria diet induced obesity and hyperglycemia, which was only partially moderated by exercise. It also induced several changes in CNS metabolites such as reduced hippocampal glutamate (Glu), choline-containing compounds (tCho) and N-acetylaspartate (NAA)+ N-acetyl-aspartyl-glutamic acid (NAAG) (tNAA) levels, whereas opposite effects were seen for running. No association of these effects with markers of central inflammation could be observed. These findings suggest that while voluntary wheel running alone is insufficient to prevent the unfavorable peripheral sequelae of the diet, it counteracted many changes in brain metabolites. The observed effects seem to be independent of neuroinflammation. </jats:p> Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study Journal of Cerebral Blood Flow & Metabolism |
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| title |
Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| title_unstemmed |
Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| title_full |
Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| title_fullStr |
Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
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Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| title_short |
Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| title_sort |
effects of a high-caloric diet and physical exercise on brain metabolite levels: a combined proton mrs and histologic study |
| topic |
Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology |
| url |
http://dx.doi.org/10.1038/jcbfm.2014.231 |
| publishDate |
2015 |
| physical |
554-564 |
| description |
<jats:p> Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS). It has been suggested that one mechanism in this context is the promotion of neuroinflammation. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating the effects of physical exercise in a cafeteria-diet mouse model on CNS metabolites by means of in vivo proton magnetic resonance spectroscopy (<jats:sup>1</jats:sup>HMRS). In addition postmortem histologic and real-time (RT)-PCR analyses for inflammatory markers were performed. Cafeteria diet induced obesity and hyperglycemia, which was only partially moderated by exercise. It also induced several changes in CNS metabolites such as reduced hippocampal glutamate (Glu), choline-containing compounds (tCho) and N-acetylaspartate (NAA)+ N-acetyl-aspartyl-glutamic acid (NAAG) (tNAA) levels, whereas opposite effects were seen for running. No association of these effects with markers of central inflammation could be observed. These findings suggest that while voluntary wheel running alone is insufficient to prevent the unfavorable peripheral sequelae of the diet, it counteracted many changes in brain metabolites. The observed effects seem to be independent of neuroinflammation. </jats:p> |
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| description | <jats:p> Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS). It has been suggested that one mechanism in this context is the promotion of neuroinflammation. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating the effects of physical exercise in a cafeteria-diet mouse model on CNS metabolites by means of in vivo proton magnetic resonance spectroscopy (<jats:sup>1</jats:sup>HMRS). In addition postmortem histologic and real-time (RT)-PCR analyses for inflammatory markers were performed. Cafeteria diet induced obesity and hyperglycemia, which was only partially moderated by exercise. It also induced several changes in CNS metabolites such as reduced hippocampal glutamate (Glu), choline-containing compounds (tCho) and N-acetylaspartate (NAA)+ N-acetyl-aspartyl-glutamic acid (NAAG) (tNAA) levels, whereas opposite effects were seen for running. No association of these effects with markers of central inflammation could be observed. These findings suggest that while voluntary wheel running alone is insufficient to prevent the unfavorable peripheral sequelae of the diet, it counteracted many changes in brain metabolites. The observed effects seem to be independent of neuroinflammation. </jats:p> |
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| spelling | Auer, Matthias K Sack, Markus Lenz, Jenny N Jakovcevski, Mira Biedermann, Sarah V Falfán-Melgoza, Claudia Deussing, Jan Steinle, Jörg Bielohuby, Maximilian Bidlingmaier, Martin Pfister, Frederik Stalla, Günter K Ende, Gabriele Weber-Fahr, Wolfgang Fuss, Johannes Gass, Peter 0271-678X 1559-7016 SAGE Publications Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology http://dx.doi.org/10.1038/jcbfm.2014.231 <jats:p> Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS). It has been suggested that one mechanism in this context is the promotion of neuroinflammation. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating the effects of physical exercise in a cafeteria-diet mouse model on CNS metabolites by means of in vivo proton magnetic resonance spectroscopy (<jats:sup>1</jats:sup>HMRS). In addition postmortem histologic and real-time (RT)-PCR analyses for inflammatory markers were performed. Cafeteria diet induced obesity and hyperglycemia, which was only partially moderated by exercise. It also induced several changes in CNS metabolites such as reduced hippocampal glutamate (Glu), choline-containing compounds (tCho) and N-acetylaspartate (NAA)+ N-acetyl-aspartyl-glutamic acid (NAAG) (tNAA) levels, whereas opposite effects were seen for running. No association of these effects with markers of central inflammation could be observed. These findings suggest that while voluntary wheel running alone is insufficient to prevent the unfavorable peripheral sequelae of the diet, it counteracted many changes in brain metabolites. The observed effects seem to be independent of neuroinflammation. </jats:p> Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study Journal of Cerebral Blood Flow & Metabolism |
| spellingShingle | Auer, Matthias K, Sack, Markus, Lenz, Jenny N, Jakovcevski, Mira, Biedermann, Sarah V, Falfán-Melgoza, Claudia, Deussing, Jan, Steinle, Jörg, Bielohuby, Maximilian, Bidlingmaier, Martin, Pfister, Frederik, Stalla, Günter K, Ende, Gabriele, Weber-Fahr, Wolfgang, Fuss, Johannes, Gass, Peter, Journal of Cerebral Blood Flow & Metabolism, Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study, Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology |
| title | Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| title_full | Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| title_fullStr | Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| title_full_unstemmed | Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| title_short | Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| title_sort | effects of a high-caloric diet and physical exercise on brain metabolite levels: a combined proton mrs and histologic study |
| title_unstemmed | Effects of a High-Caloric Diet and Physical Exercise on Brain Metabolite Levels: A Combined Proton MRS and Histologic Study |
| topic | Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology |
| url | http://dx.doi.org/10.1038/jcbfm.2014.231 |