Eintrag weiter verarbeiten
Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction s...
Gespeichert in:
Zeitschriftentitel: | Epidemiology and Infection |
---|---|
Personen und Körperschaften: | , , |
In: | Epidemiology and Infection, 147, 2019 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Cambridge University Press (CUP)
|
Schlagwörter: |
author_facet |
Qi, R. Huang, Y.T. Yu, X.J. Qi, R. Huang, Y.T. Yu, X.J. |
---|---|
author |
Qi, R. Huang, Y.T. Yu, X.J. |
spellingShingle |
Qi, R. Huang, Y.T. Yu, X.J. Epidemiology and Infection Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study Infectious Diseases Epidemiology |
author_sort |
qi, r. |
spelling |
Qi, R. Huang, Y.T. Yu, X.J. 0950-2688 1469-4409 Cambridge University Press (CUP) Infectious Diseases Epidemiology http://dx.doi.org/10.1017/s1469440918003643 <jats:title>Summary</jats:title><jats:p>Severe fever with thrombocytopaenia syndrome (SFTS) is an emerging infectious disease discovered in 2010 and has a case fatality as high as 30%. We intended to study the immune protection conferred by SFTS with natural infection. We collected and analysed 4-year follow-up data to study the characteristics of neutralising antibodies against SFTS virus (SFTSV). The 50% plaque reduction neutralisation test was used for the detection of neutralising antibodies against SFTSV. Geometric mean titres (GMTs) and proportions of patients with a protective titre were analysed, and the persistence of protection was predicted. The titre of antibodies declined yearly in the 4-year study period. Approximately 3 months after infection, the GMT was 143 (95% confidence interval (CI): 89–231), and 100% of patients had a protective titre. In the fourth year, the GMT declined to 53 (95% CI: 37–76), and 95% of patients had a protective titre. The titre was higher in females than in males. On average, the protection offered by neutralising antibodies against SFTSV could last as long as 9 years. The durations of protection were different for different initial titres. The characteristics of neutralising antibodies can be used as a reference for the vaccination doses and schedules of forthcoming vaccines.</jats:p> Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study Epidemiology and Infection |
doi_str_mv |
10.1017/s1469440918003643 |
facet_avail |
Online Free |
finc_class_facet |
Medizin |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNy9zMTQ2OTQ0MDkxODAwMzY0Mw |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNy9zMTQ2OTQ0MDkxODAwMzY0Mw |
institution |
DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
imprint |
Cambridge University Press (CUP), 2019 |
imprint_str_mv |
Cambridge University Press (CUP), 2019 |
issn |
0950-2688 1469-4409 |
issn_str_mv |
0950-2688 1469-4409 |
language |
English |
mega_collection |
Cambridge University Press (CUP) (CrossRef) |
match_str |
qi2019persistenceandgenderdifferencesinprotectionagainstseverefeverwiththrombocytopaeniasyndromeviruswithnaturalinfectiona4yearfollowupandmathematicalpredictionstudy |
publishDateSort |
2019 |
publisher |
Cambridge University Press (CUP) |
recordtype |
ai |
record_format |
ai |
series |
Epidemiology and Infection |
source_id |
49 |
title |
Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_unstemmed |
Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_full |
Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_fullStr |
Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_full_unstemmed |
Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_short |
Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_sort |
persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
topic |
Infectious Diseases Epidemiology |
url |
http://dx.doi.org/10.1017/s1469440918003643 |
publishDate |
2019 |
physical |
|
description |
<jats:title>Summary</jats:title><jats:p>Severe fever with thrombocytopaenia syndrome (SFTS) is an emerging infectious disease discovered in 2010 and has a case fatality as high as 30%. We intended to study the immune protection conferred by SFTS with natural infection. We collected and analysed 4-year follow-up data to study the characteristics of neutralising antibodies against SFTS virus (SFTSV). The 50% plaque reduction neutralisation test was used for the detection of neutralising antibodies against SFTSV. Geometric mean titres (GMTs) and proportions of patients with a protective titre were analysed, and the persistence of protection was predicted. The titre of antibodies declined yearly in the 4-year study period. Approximately 3 months after infection, the GMT was 143 (95% confidence interval (CI): 89–231), and 100% of patients had a protective titre. In the fourth year, the GMT declined to 53 (95% CI: 37–76), and 95% of patients had a protective titre. The titre was higher in females than in males. On average, the protection offered by neutralising antibodies against SFTSV could last as long as 9 years. The durations of protection were different for different initial titres. The characteristics of neutralising antibodies can be used as a reference for the vaccination doses and schedules of forthcoming vaccines.</jats:p> |
container_start_page |
0 |
container_title |
Epidemiology and Infection |
container_volume |
147 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792332272095985678 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T13:53:50.726Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Persistence+and+gender+differences+in+protection+against+severe+fever+with+thrombocytopaenia+syndrome+virus+with+natural+infection%3A+a+4-year+follow-up+and+mathematical+prediction+study&rft.date=2019-01-01&genre=article&issn=1469-4409&volume=147&jtitle=Epidemiology+and+Infection&atitle=Persistence+and+gender+differences+in+protection+against+severe+fever+with+thrombocytopaenia+syndrome+virus+with+natural+infection%3A+a+4-year+follow-up+and+mathematical+prediction+study&aulast=Yu&aufirst=X.J.&rft_id=info%3Adoi%2F10.1017%2Fs1469440918003643&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792332272095985678 |
author | Qi, R., Huang, Y.T., Yu, X.J. |
author_facet | Qi, R., Huang, Y.T., Yu, X.J., Qi, R., Huang, Y.T., Yu, X.J. |
author_sort | qi, r. |
container_start_page | 0 |
container_title | Epidemiology and Infection |
container_volume | 147 |
description | <jats:title>Summary</jats:title><jats:p>Severe fever with thrombocytopaenia syndrome (SFTS) is an emerging infectious disease discovered in 2010 and has a case fatality as high as 30%. We intended to study the immune protection conferred by SFTS with natural infection. We collected and analysed 4-year follow-up data to study the characteristics of neutralising antibodies against SFTS virus (SFTSV). The 50% plaque reduction neutralisation test was used for the detection of neutralising antibodies against SFTSV. Geometric mean titres (GMTs) and proportions of patients with a protective titre were analysed, and the persistence of protection was predicted. The titre of antibodies declined yearly in the 4-year study period. Approximately 3 months after infection, the GMT was 143 (95% confidence interval (CI): 89–231), and 100% of patients had a protective titre. In the fourth year, the GMT declined to 53 (95% CI: 37–76), and 95% of patients had a protective titre. The titre was higher in females than in males. On average, the protection offered by neutralising antibodies against SFTSV could last as long as 9 years. The durations of protection were different for different initial titres. The characteristics of neutralising antibodies can be used as a reference for the vaccination doses and schedules of forthcoming vaccines.</jats:p> |
doi_str_mv | 10.1017/s1469440918003643 |
facet_avail | Online, Free |
finc_class_facet | Medizin |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNy9zMTQ2OTQ0MDkxODAwMzY0Mw |
imprint | Cambridge University Press (CUP), 2019 |
imprint_str_mv | Cambridge University Press (CUP), 2019 |
institution | DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
issn | 0950-2688, 1469-4409 |
issn_str_mv | 0950-2688, 1469-4409 |
language | English |
last_indexed | 2024-03-01T13:53:50.726Z |
match_str | qi2019persistenceandgenderdifferencesinprotectionagainstseverefeverwiththrombocytopaeniasyndromeviruswithnaturalinfectiona4yearfollowupandmathematicalpredictionstudy |
mega_collection | Cambridge University Press (CUP) (CrossRef) |
physical | |
publishDate | 2019 |
publishDateSort | 2019 |
publisher | Cambridge University Press (CUP) |
record_format | ai |
recordtype | ai |
series | Epidemiology and Infection |
source_id | 49 |
spelling | Qi, R. Huang, Y.T. Yu, X.J. 0950-2688 1469-4409 Cambridge University Press (CUP) Infectious Diseases Epidemiology http://dx.doi.org/10.1017/s1469440918003643 <jats:title>Summary</jats:title><jats:p>Severe fever with thrombocytopaenia syndrome (SFTS) is an emerging infectious disease discovered in 2010 and has a case fatality as high as 30%. We intended to study the immune protection conferred by SFTS with natural infection. We collected and analysed 4-year follow-up data to study the characteristics of neutralising antibodies against SFTS virus (SFTSV). The 50% plaque reduction neutralisation test was used for the detection of neutralising antibodies against SFTSV. Geometric mean titres (GMTs) and proportions of patients with a protective titre were analysed, and the persistence of protection was predicted. The titre of antibodies declined yearly in the 4-year study period. Approximately 3 months after infection, the GMT was 143 (95% confidence interval (CI): 89–231), and 100% of patients had a protective titre. In the fourth year, the GMT declined to 53 (95% CI: 37–76), and 95% of patients had a protective titre. The titre was higher in females than in males. On average, the protection offered by neutralising antibodies against SFTSV could last as long as 9 years. The durations of protection were different for different initial titres. The characteristics of neutralising antibodies can be used as a reference for the vaccination doses and schedules of forthcoming vaccines.</jats:p> Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study Epidemiology and Infection |
spellingShingle | Qi, R., Huang, Y.T., Yu, X.J., Epidemiology and Infection, Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study, Infectious Diseases, Epidemiology |
title | Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_full | Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_fullStr | Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_full_unstemmed | Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_short | Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_sort | persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
title_unstemmed | Persistence and gender differences in protection against severe fever with thrombocytopaenia syndrome virus with natural infection: a 4-year follow-up and mathematical prediction study |
topic | Infectious Diseases, Epidemiology |
url | http://dx.doi.org/10.1017/s1469440918003643 |