Eintrag weiter verarbeiten
Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk
Gespeichert in:
| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | FEBS Letters, 558, 2004, 1-3, S. 79-84 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Mutalik, Vivek K. Singh, Aditya P. Edwards, Jeremy S. Venkatesh, K.V. Mutalik, Vivek K. Singh, Aditya P. Edwards, Jeremy S. Venkatesh, K.V. |
|---|---|
| author |
Mutalik, Vivek K. Singh, Aditya P. Edwards, Jeremy S. Venkatesh, K.V. |
| spellingShingle |
Mutalik, Vivek K. Singh, Aditya P. Edwards, Jeremy S. Venkatesh, K.V. FEBS Letters Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
mutalik, vivek k. |
| spelling |
Mutalik, Vivek K. Singh, Aditya P. Edwards, Jeremy S. Venkatesh, K.V. 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/s0014-5793(04)00021-3 <jats:p>A steady‐state framework was applied to the ubiquitous tricyclic enzyme cascade structure, as seen in the mitogen‐activated protein (MAP) kinase system, to analyze the effect of upstream kinase concentrations on final output response. The results suggest that signal amplification achieved by the cascade structure ensured that the modifying enzymes at various steps of the cascade were nearly saturated. Thus, there was no change in the response sensitivity with increasing upstream kinase concentration. Analysis was also extended to branching of a signaling pathway as an example of cross‐talk. It was observed that the cascade structure confers a larger share of the signal transduction properties to its last kinase. This phenomenon in enzyme cascades may explain how the response of the terminal MAP kinase is unaffected by cross‐talk of upstream kinases.</jats:p> Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk FEBS Letters |
| doi_str_mv |
10.1016/s0014-5793(04)00021-3 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Chemie und Pharmazie Physik |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9zMDAxNC01NzkzKDA0KTAwMDIxLTM |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9zMDAxNC01NzkzKDA0KTAwMDIxLTM |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Zwi2 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
Wiley, 2004 |
| imprint_str_mv |
Wiley, 2004 |
| issn |
1873-3468 0014-5793 |
| issn_str_mv |
1873-3468 0014-5793 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
mutalik2004robustglobalsensitivityinmultipleenzymecascadesystemexplainshowthedownstreamcascadestructuremayremainunaffectedbycrosstalk |
| publishDateSort |
2004 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
FEBS Letters |
| source_id |
49 |
| title |
Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_unstemmed |
Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_full |
Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_fullStr |
Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_full_unstemmed |
Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_short |
Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_sort |
robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| topic |
Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| url |
http://dx.doi.org/10.1016/s0014-5793(04)00021-3 |
| publishDate |
2004 |
| physical |
79-84 |
| description |
<jats:p>A steady‐state framework was applied to the ubiquitous tricyclic enzyme cascade structure, as seen in the mitogen‐activated protein (MAP) kinase system, to analyze the effect of upstream kinase concentrations on final output response. The results suggest that signal amplification achieved by the cascade structure ensured that the modifying enzymes at various steps of the cascade were nearly saturated. Thus, there was no change in the response sensitivity with increasing upstream kinase concentration. Analysis was also extended to branching of a signaling pathway as an example of cross‐talk. It was observed that the cascade structure confers a larger share of the signal transduction properties to its last kinase. This phenomenon in enzyme cascades may explain how the response of the terminal MAP kinase is unaffected by cross‐talk of upstream kinases.</jats:p> |
| container_issue |
1-3 |
| container_start_page |
79 |
| container_title |
FEBS Letters |
| container_volume |
558 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792335538377719812 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:45:34.65Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Robust+global+sensitivity+in+multiple+enzyme+cascade+system+explains+how+the+downstream+cascade+structure+may+remain+unaffected+by+cross%E2%80%90talk&rft.date=2004-01-30&genre=article&issn=1873-3468&volume=558&issue=1-3&spage=79&epage=84&pages=79-84&jtitle=FEBS+Letters&atitle=Robust+global+sensitivity+in+multiple+enzyme+cascade+system+explains+how+the+downstream+cascade+structure+may+remain+unaffected+by+cross%E2%80%90talk&aulast=Venkatesh&aufirst=K.V.&rft_id=info%3Adoi%2F10.1016%2Fs0014-5793%2804%2900021-3&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792335538377719812 |
| author | Mutalik, Vivek K., Singh, Aditya P., Edwards, Jeremy S., Venkatesh, K.V. |
| author_facet | Mutalik, Vivek K., Singh, Aditya P., Edwards, Jeremy S., Venkatesh, K.V., Mutalik, Vivek K., Singh, Aditya P., Edwards, Jeremy S., Venkatesh, K.V. |
| author_sort | mutalik, vivek k. |
| container_issue | 1-3 |
| container_start_page | 79 |
| container_title | FEBS Letters |
| container_volume | 558 |
| description | <jats:p>A steady‐state framework was applied to the ubiquitous tricyclic enzyme cascade structure, as seen in the mitogen‐activated protein (MAP) kinase system, to analyze the effect of upstream kinase concentrations on final output response. The results suggest that signal amplification achieved by the cascade structure ensured that the modifying enzymes at various steps of the cascade were nearly saturated. Thus, there was no change in the response sensitivity with increasing upstream kinase concentration. Analysis was also extended to branching of a signaling pathway as an example of cross‐talk. It was observed that the cascade structure confers a larger share of the signal transduction properties to its last kinase. This phenomenon in enzyme cascades may explain how the response of the terminal MAP kinase is unaffected by cross‐talk of upstream kinases.</jats:p> |
| doi_str_mv | 10.1016/s0014-5793(04)00021-3 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Chemie und Pharmazie, Physik |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9zMDAxNC01NzkzKDA0KTAwMDIxLTM |
| imprint | Wiley, 2004 |
| imprint_str_mv | Wiley, 2004 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1873-3468, 0014-5793 |
| issn_str_mv | 1873-3468, 0014-5793 |
| language | English |
| last_indexed | 2024-03-01T14:45:34.65Z |
| match_str | mutalik2004robustglobalsensitivityinmultipleenzymecascadesystemexplainshowthedownstreamcascadestructuremayremainunaffectedbycrosstalk |
| mega_collection | Wiley (CrossRef) |
| physical | 79-84 |
| publishDate | 2004 |
| publishDateSort | 2004 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | FEBS Letters |
| source_id | 49 |
| spelling | Mutalik, Vivek K. Singh, Aditya P. Edwards, Jeremy S. Venkatesh, K.V. 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/s0014-5793(04)00021-3 <jats:p>A steady‐state framework was applied to the ubiquitous tricyclic enzyme cascade structure, as seen in the mitogen‐activated protein (MAP) kinase system, to analyze the effect of upstream kinase concentrations on final output response. The results suggest that signal amplification achieved by the cascade structure ensured that the modifying enzymes at various steps of the cascade were nearly saturated. Thus, there was no change in the response sensitivity with increasing upstream kinase concentration. Analysis was also extended to branching of a signaling pathway as an example of cross‐talk. It was observed that the cascade structure confers a larger share of the signal transduction properties to its last kinase. This phenomenon in enzyme cascades may explain how the response of the terminal MAP kinase is unaffected by cross‐talk of upstream kinases.</jats:p> Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk FEBS Letters |
| spellingShingle | Mutalik, Vivek K., Singh, Aditya P., Edwards, Jeremy S., Venkatesh, K.V., FEBS Letters, Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_full | Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_fullStr | Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_full_unstemmed | Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_short | Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_sort | robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| title_unstemmed | Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross‐talk |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1016/s0014-5793(04)00021-3 |