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Kinetic mechanisms for overexpression insensitivity and oncogene cooperation

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Zeitschriftentitel: FEBS Letters
Personen und Körperschaften: Legewie, Stefan, Sers, Christine, Herzel, Hanspeter
In: FEBS Letters, 583, 2009, 1, S. 93-96
Format: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Cell Biology
Genetics
Molecular Biology
Biochemistry
Structural Biology
Biophysics
author_facet Legewie, Stefan
Sers, Christine
Herzel, Hanspeter
Legewie, Stefan
Sers, Christine
Herzel, Hanspeter
author Legewie, Stefan
Sers, Christine
Herzel, Hanspeter
spellingShingle Legewie, Stefan
Sers, Christine
Herzel, Hanspeter
FEBS Letters
Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
Cell Biology
Genetics
Molecular Biology
Biochemistry
Structural Biology
Biophysics
author_sort legewie, stefan
spelling Legewie, Stefan Sers, Christine Herzel, Hanspeter 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/j.febslet.2008.11.027 <jats:p>Minor (5–10 fold) activation of mitogenic signalling cascades typically induces cell division upon extracellular stimulation and is sufficient to support tumourigenesis when permanently triggered by activating mutations. Surprisingly, even strong signalling protein overexpression usually does not trigger deregulated cell proliferation, suggesting that basal state signalling is insensitive to wildtype protein overexpression. Using kinetic modelling of the core Ras cycle, we show that basal RasGTP signalling can be insensitive to Ras overexpression and thus identify a possible tumour suppression mechanism. We further show how phenotypically silent overexpression events within signalling cascades cooperate to bring about carcinogenesis. Our analyses underscore the need for a systems level understanding of tumour formation.</jats:p> Kinetic mechanisms for overexpression insensitivity and oncogene cooperation FEBS Letters
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title Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_unstemmed Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_full Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_fullStr Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_full_unstemmed Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_short Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_sort kinetic mechanisms for overexpression insensitivity and oncogene cooperation
topic Cell Biology
Genetics
Molecular Biology
Biochemistry
Structural Biology
Biophysics
url http://dx.doi.org/10.1016/j.febslet.2008.11.027
publishDate 2009
physical 93-96
description <jats:p>Minor (5–10 fold) activation of mitogenic signalling cascades typically induces cell division upon extracellular stimulation and is sufficient to support tumourigenesis when permanently triggered by activating mutations. Surprisingly, even strong signalling protein overexpression usually does not trigger deregulated cell proliferation, suggesting that basal state signalling is insensitive to wildtype protein overexpression. Using kinetic modelling of the core Ras cycle, we show that basal RasGTP signalling can be insensitive to Ras overexpression and thus identify a possible tumour suppression mechanism. We further show how phenotypically silent overexpression events within signalling cascades cooperate to bring about carcinogenesis. Our analyses underscore the need for a systems level understanding of tumour formation.</jats:p>
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author Legewie, Stefan, Sers, Christine, Herzel, Hanspeter
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author_sort legewie, stefan
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container_title FEBS Letters
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description <jats:p>Minor (5–10 fold) activation of mitogenic signalling cascades typically induces cell division upon extracellular stimulation and is sufficient to support tumourigenesis when permanently triggered by activating mutations. Surprisingly, even strong signalling protein overexpression usually does not trigger deregulated cell proliferation, suggesting that basal state signalling is insensitive to wildtype protein overexpression. Using kinetic modelling of the core Ras cycle, we show that basal RasGTP signalling can be insensitive to Ras overexpression and thus identify a possible tumour suppression mechanism. We further show how phenotypically silent overexpression events within signalling cascades cooperate to bring about carcinogenesis. Our analyses underscore the need for a systems level understanding of tumour formation.</jats:p>
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spelling Legewie, Stefan Sers, Christine Herzel, Hanspeter 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/j.febslet.2008.11.027 <jats:p>Minor (5–10 fold) activation of mitogenic signalling cascades typically induces cell division upon extracellular stimulation and is sufficient to support tumourigenesis when permanently triggered by activating mutations. Surprisingly, even strong signalling protein overexpression usually does not trigger deregulated cell proliferation, suggesting that basal state signalling is insensitive to wildtype protein overexpression. Using kinetic modelling of the core Ras cycle, we show that basal RasGTP signalling can be insensitive to Ras overexpression and thus identify a possible tumour suppression mechanism. We further show how phenotypically silent overexpression events within signalling cascades cooperate to bring about carcinogenesis. Our analyses underscore the need for a systems level understanding of tumour formation.</jats:p> Kinetic mechanisms for overexpression insensitivity and oncogene cooperation FEBS Letters
spellingShingle Legewie, Stefan, Sers, Christine, Herzel, Hanspeter, FEBS Letters, Kinetic mechanisms for overexpression insensitivity and oncogene cooperation, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics
title Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_full Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_fullStr Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_full_unstemmed Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_short Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_sort kinetic mechanisms for overexpression insensitivity and oncogene cooperation
title_unstemmed Kinetic mechanisms for overexpression insensitivity and oncogene cooperation
topic Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics
url http://dx.doi.org/10.1016/j.febslet.2008.11.027