Synthesis of a large peptide mimicking the DNA binding properties of the sex determining protein, SRY

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Bibliographische Detailangaben
Zeitschriftentitel:	FEBS Letters
Personen und Körperschaften:	Poulat, F., Guichard, G., Gozé, C., Heitz, F., Calas, B., Berta, P.
In:	FEBS Letters, 309, 1992, 3, S. 385-388
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Wiley
Schlagwörter:	Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics

Details
Zusammenfassung:	<jats:p>The sex determining protein, SRY, has been recently described as containing a DNA binding motif, also called the SRY box. This 80 amino acid box was synthesized using the continuous flow solid‐phase technique. The product was then purified and tested according to such diverse criteria as its intrinsic structure or its biological activity (DNA binding capacity), and compared to the full‐length protein. The data indicate that the peptide is relevant for the properties described so far for the protein.</jats:p>
Umfang:	385-388
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(92)80812-u