Eintrag weiter verarbeiten
Targeting the enhancer of zeste homologue 2 in medulloblastoma
Gespeichert in:
| Zeitschriftentitel: | International Journal of Cancer |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | International Journal of Cancer, 131, 2012, 8, S. 1800-1809 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Alimova, Irina Venkataraman, Sujatha Harris, Peter Marquez, Victor E. Northcott, Paul A. Dubuc, Adrian Taylor, Michael D. Foreman, Nicholas K. Vibhakar, Rajeev Alimova, Irina Venkataraman, Sujatha Harris, Peter Marquez, Victor E. Northcott, Paul A. Dubuc, Adrian Taylor, Michael D. Foreman, Nicholas K. Vibhakar, Rajeev |
|---|---|
| author |
Alimova, Irina Venkataraman, Sujatha Harris, Peter Marquez, Victor E. Northcott, Paul A. Dubuc, Adrian Taylor, Michael D. Foreman, Nicholas K. Vibhakar, Rajeev |
| spellingShingle |
Alimova, Irina Venkataraman, Sujatha Harris, Peter Marquez, Victor E. Northcott, Paul A. Dubuc, Adrian Taylor, Michael D. Foreman, Nicholas K. Vibhakar, Rajeev International Journal of Cancer Targeting the enhancer of zeste homologue 2 in medulloblastoma Cancer Research Oncology |
| author_sort |
alimova, irina |
| spelling |
Alimova, Irina Venkataraman, Sujatha Harris, Peter Marquez, Victor E. Northcott, Paul A. Dubuc, Adrian Taylor, Michael D. Foreman, Nicholas K. Vibhakar, Rajeev 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.27455 <jats:title>Abstract</jats:title><jats:p>Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and represses gene transcription. EZH2 enhances cancer‐cell proliferation and regulates stem cell maintenance and differentiation. Here, we demonstrate that EZH2 is highly expressed in medulloblastoma, a highly malignant brain tumor of childhood, and this altered expression is correlated with genomic gain of chromosome 7 in a subset of medulloblastoma. Inhibition of EZH2 by RNAi suppresses medulloblastoma tumor cell growth. We show that 3‐deazaneplanocin A, a chemical inhibitor of EZH2, can suppress medulloblastoma cell growth partially by inducing apoptosis. Suppression of EZH2 expression diminishes the ability of tumor cells to form spheres in culture and strongly represses the ability of known oncogenes to transform neural stem cells. These findings establish a role of EZH2 in medulloblastoma and identify EZH2 as a potential therapeutic target especially in high‐risk tumors.</jats:p> Targeting the enhancer of zeste homologue 2 in medulloblastoma International Journal of Cancer |
| doi_str_mv |
10.1002/ijc.27455 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9pamMuMjc0NTU |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9pamMuMjc0NTU |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Zwi2 |
| imprint |
Wiley, 2012 |
| imprint_str_mv |
Wiley, 2012 |
| issn |
0020-7136 1097-0215 |
| issn_str_mv |
0020-7136 1097-0215 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
alimova2012targetingtheenhancerofzestehomologue2inmedulloblastoma |
| publishDateSort |
2012 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
International Journal of Cancer |
| source_id |
49 |
| title |
Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_unstemmed |
Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_full |
Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_fullStr |
Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_full_unstemmed |
Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_short |
Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_sort |
targeting the enhancer of zeste homologue 2 in medulloblastoma |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1002/ijc.27455 |
| publishDate |
2012 |
| physical |
1800-1809 |
| description |
<jats:title>Abstract</jats:title><jats:p>Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and represses gene transcription. EZH2 enhances cancer‐cell proliferation and regulates stem cell maintenance and differentiation. Here, we demonstrate that EZH2 is highly expressed in medulloblastoma, a highly malignant brain tumor of childhood, and this altered expression is correlated with genomic gain of chromosome 7 in a subset of medulloblastoma. Inhibition of EZH2 by RNAi suppresses medulloblastoma tumor cell growth. We show that 3‐deazaneplanocin A, a chemical inhibitor of EZH2, can suppress medulloblastoma cell growth partially by inducing apoptosis. Suppression of EZH2 expression diminishes the ability of tumor cells to form spheres in culture and strongly represses the ability of known oncogenes to transform neural stem cells. These findings establish a role of EZH2 in medulloblastoma and identify EZH2 as a potential therapeutic target especially in high‐risk tumors.</jats:p> |
| container_issue |
8 |
| container_start_page |
1800 |
| container_title |
International Journal of Cancer |
| container_volume |
131 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792346247962558468 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:36:20.909Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Targeting+the+enhancer+of+zeste+homologue+2+in+medulloblastoma&rft.date=2012-10-15&genre=article&issn=1097-0215&volume=131&issue=8&spage=1800&epage=1809&pages=1800-1809&jtitle=International+Journal+of+Cancer&atitle=Targeting+the+enhancer+of+zeste+homologue+2+in+medulloblastoma&aulast=Vibhakar&aufirst=Rajeev&rft_id=info%3Adoi%2F10.1002%2Fijc.27455&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792346247962558468 |
| author | Alimova, Irina, Venkataraman, Sujatha, Harris, Peter, Marquez, Victor E., Northcott, Paul A., Dubuc, Adrian, Taylor, Michael D., Foreman, Nicholas K., Vibhakar, Rajeev |
| author_facet | Alimova, Irina, Venkataraman, Sujatha, Harris, Peter, Marquez, Victor E., Northcott, Paul A., Dubuc, Adrian, Taylor, Michael D., Foreman, Nicholas K., Vibhakar, Rajeev, Alimova, Irina, Venkataraman, Sujatha, Harris, Peter, Marquez, Victor E., Northcott, Paul A., Dubuc, Adrian, Taylor, Michael D., Foreman, Nicholas K., Vibhakar, Rajeev |
| author_sort | alimova, irina |
| container_issue | 8 |
| container_start_page | 1800 |
| container_title | International Journal of Cancer |
| container_volume | 131 |
| description | <jats:title>Abstract</jats:title><jats:p>Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and represses gene transcription. EZH2 enhances cancer‐cell proliferation and regulates stem cell maintenance and differentiation. Here, we demonstrate that EZH2 is highly expressed in medulloblastoma, a highly malignant brain tumor of childhood, and this altered expression is correlated with genomic gain of chromosome 7 in a subset of medulloblastoma. Inhibition of EZH2 by RNAi suppresses medulloblastoma tumor cell growth. We show that 3‐deazaneplanocin A, a chemical inhibitor of EZH2, can suppress medulloblastoma cell growth partially by inducing apoptosis. Suppression of EZH2 expression diminishes the ability of tumor cells to form spheres in culture and strongly represses the ability of known oncogenes to transform neural stem cells. These findings establish a role of EZH2 in medulloblastoma and identify EZH2 as a potential therapeutic target especially in high‐risk tumors.</jats:p> |
| doi_str_mv | 10.1002/ijc.27455 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9pamMuMjc0NTU |
| imprint | Wiley, 2012 |
| imprint_str_mv | Wiley, 2012 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2 |
| issn | 0020-7136, 1097-0215 |
| issn_str_mv | 0020-7136, 1097-0215 |
| language | English |
| last_indexed | 2024-03-01T17:36:20.909Z |
| match_str | alimova2012targetingtheenhancerofzestehomologue2inmedulloblastoma |
| mega_collection | Wiley (CrossRef) |
| physical | 1800-1809 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | International Journal of Cancer |
| source_id | 49 |
| spelling | Alimova, Irina Venkataraman, Sujatha Harris, Peter Marquez, Victor E. Northcott, Paul A. Dubuc, Adrian Taylor, Michael D. Foreman, Nicholas K. Vibhakar, Rajeev 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.27455 <jats:title>Abstract</jats:title><jats:p>Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and represses gene transcription. EZH2 enhances cancer‐cell proliferation and regulates stem cell maintenance and differentiation. Here, we demonstrate that EZH2 is highly expressed in medulloblastoma, a highly malignant brain tumor of childhood, and this altered expression is correlated with genomic gain of chromosome 7 in a subset of medulloblastoma. Inhibition of EZH2 by RNAi suppresses medulloblastoma tumor cell growth. We show that 3‐deazaneplanocin A, a chemical inhibitor of EZH2, can suppress medulloblastoma cell growth partially by inducing apoptosis. Suppression of EZH2 expression diminishes the ability of tumor cells to form spheres in culture and strongly represses the ability of known oncogenes to transform neural stem cells. These findings establish a role of EZH2 in medulloblastoma and identify EZH2 as a potential therapeutic target especially in high‐risk tumors.</jats:p> Targeting the enhancer of zeste homologue 2 in medulloblastoma International Journal of Cancer |
| spellingShingle | Alimova, Irina, Venkataraman, Sujatha, Harris, Peter, Marquez, Victor E., Northcott, Paul A., Dubuc, Adrian, Taylor, Michael D., Foreman, Nicholas K., Vibhakar, Rajeev, International Journal of Cancer, Targeting the enhancer of zeste homologue 2 in medulloblastoma, Cancer Research, Oncology |
| title | Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_full | Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_fullStr | Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_full_unstemmed | Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_short | Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_sort | targeting the enhancer of zeste homologue 2 in medulloblastoma |
| title_unstemmed | Targeting the enhancer of zeste homologue 2 in medulloblastoma |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1002/ijc.27455 |