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Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma
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| Zeitschriftentitel: | International Journal of Cancer |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | International Journal of Cancer, 124, 2009, 6, S. 1285-1292 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Bennett, Kristi L. Romigh, Todd Arab, Khelifa Teresi, Rosemary E. Tada, Yasuhiro Eng, Charis Plass, Christoph Bennett, Kristi L. Romigh, Todd Arab, Khelifa Teresi, Rosemary E. Tada, Yasuhiro Eng, Charis Plass, Christoph |
|---|---|
| author |
Bennett, Kristi L. Romigh, Todd Arab, Khelifa Teresi, Rosemary E. Tada, Yasuhiro Eng, Charis Plass, Christoph |
| spellingShingle |
Bennett, Kristi L. Romigh, Todd Arab, Khelifa Teresi, Rosemary E. Tada, Yasuhiro Eng, Charis Plass, Christoph International Journal of Cancer Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma Cancer Research Oncology |
| author_sort |
bennett, kristi l. |
| spelling |
Bennett, Kristi L. Romigh, Todd Arab, Khelifa Teresi, Rosemary E. Tada, Yasuhiro Eng, Charis Plass, Christoph 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.24087 <jats:title>Abstract</jats:title><jats:p>The tumor suppressor <jats:italic>C/CAAT</jats:italic> enhancer binding protein alpha (<jats:italic>C/EBP</jats:italic>α) is a transcription factor involved in cell cycle control and cellular differentiation. A recent study showed that <jats:italic>C/EBP</jats:italic>α is frequently downregulated in head and neck squamous cell carcinoma (HNSCC) by DNA methylation in an upstream regulatory region. Here, we investigated how DNA methylation in the upstream regulatory region disrupts the transcriptional regulation of <jats:italic>C/EBP</jats:italic>α in HNSCC. The results reveal that aberrant methylation correlates with methyl binding domain protein binding and repressive histone modifications. This methylated region contains previously uninvestigated AP2α binding sites. AP2α suppresses <jats:italic>C/EBP</jats:italic>α promoter activity and protein expression. Interestingly, silencing AP2α by shRNA increases the antiproliferative isoform of <jats:italic>C/EBP</jats:italic>α (p42<jats:sup>C/EBPα</jats:sup>). Furthermore, growth analysis revealed that these 2 isoforms yield very different proliferative properties in HNSCC. © 2008 Wiley‐Liss, Inc.</jats:p> Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42<sup>C/EBPα</sup>) in head and neck squamous cell carcinoma International Journal of Cancer |
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Wiley, 2009 |
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| title |
Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_unstemmed |
Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_full |
Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_fullStr |
Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_full_unstemmed |
Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_short |
Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_sort |
activator protein 2 alpha (ap2α) suppresses 42 kda c/caat enhancer binding protein α (p42<sup>c/ebpα</sup>) in head and neck squamous cell carcinoma |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1002/ijc.24087 |
| publishDate |
2009 |
| physical |
1285-1292 |
| description |
<jats:title>Abstract</jats:title><jats:p>The tumor suppressor <jats:italic>C/CAAT</jats:italic> enhancer binding protein alpha (<jats:italic>C/EBP</jats:italic>α) is a transcription factor involved in cell cycle control and cellular differentiation. A recent study showed that <jats:italic>C/EBP</jats:italic>α is frequently downregulated in head and neck squamous cell carcinoma (HNSCC) by DNA methylation in an upstream regulatory region. Here, we investigated how DNA methylation in the upstream regulatory region disrupts the transcriptional regulation of <jats:italic>C/EBP</jats:italic>α in HNSCC. The results reveal that aberrant methylation correlates with methyl binding domain protein binding and repressive histone modifications. This methylated region contains previously uninvestigated AP2α binding sites. AP2α suppresses <jats:italic>C/EBP</jats:italic>α promoter activity and protein expression. Interestingly, silencing AP2α by shRNA increases the antiproliferative isoform of <jats:italic>C/EBP</jats:italic>α (p42<jats:sup>C/EBPα</jats:sup>). Furthermore, growth analysis revealed that these 2 isoforms yield very different proliferative properties in HNSCC. © 2008 Wiley‐Liss, Inc.</jats:p> |
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| author | Bennett, Kristi L., Romigh, Todd, Arab, Khelifa, Teresi, Rosemary E., Tada, Yasuhiro, Eng, Charis, Plass, Christoph |
| author_facet | Bennett, Kristi L., Romigh, Todd, Arab, Khelifa, Teresi, Rosemary E., Tada, Yasuhiro, Eng, Charis, Plass, Christoph, Bennett, Kristi L., Romigh, Todd, Arab, Khelifa, Teresi, Rosemary E., Tada, Yasuhiro, Eng, Charis, Plass, Christoph |
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| description | <jats:title>Abstract</jats:title><jats:p>The tumor suppressor <jats:italic>C/CAAT</jats:italic> enhancer binding protein alpha (<jats:italic>C/EBP</jats:italic>α) is a transcription factor involved in cell cycle control and cellular differentiation. A recent study showed that <jats:italic>C/EBP</jats:italic>α is frequently downregulated in head and neck squamous cell carcinoma (HNSCC) by DNA methylation in an upstream regulatory region. Here, we investigated how DNA methylation in the upstream regulatory region disrupts the transcriptional regulation of <jats:italic>C/EBP</jats:italic>α in HNSCC. The results reveal that aberrant methylation correlates with methyl binding domain protein binding and repressive histone modifications. This methylated region contains previously uninvestigated AP2α binding sites. AP2α suppresses <jats:italic>C/EBP</jats:italic>α promoter activity and protein expression. Interestingly, silencing AP2α by shRNA increases the antiproliferative isoform of <jats:italic>C/EBP</jats:italic>α (p42<jats:sup>C/EBPα</jats:sup>). Furthermore, growth analysis revealed that these 2 isoforms yield very different proliferative properties in HNSCC. © 2008 Wiley‐Liss, Inc.</jats:p> |
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| spelling | Bennett, Kristi L. Romigh, Todd Arab, Khelifa Teresi, Rosemary E. Tada, Yasuhiro Eng, Charis Plass, Christoph 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.24087 <jats:title>Abstract</jats:title><jats:p>The tumor suppressor <jats:italic>C/CAAT</jats:italic> enhancer binding protein alpha (<jats:italic>C/EBP</jats:italic>α) is a transcription factor involved in cell cycle control and cellular differentiation. A recent study showed that <jats:italic>C/EBP</jats:italic>α is frequently downregulated in head and neck squamous cell carcinoma (HNSCC) by DNA methylation in an upstream regulatory region. Here, we investigated how DNA methylation in the upstream regulatory region disrupts the transcriptional regulation of <jats:italic>C/EBP</jats:italic>α in HNSCC. The results reveal that aberrant methylation correlates with methyl binding domain protein binding and repressive histone modifications. This methylated region contains previously uninvestigated AP2α binding sites. AP2α suppresses <jats:italic>C/EBP</jats:italic>α promoter activity and protein expression. Interestingly, silencing AP2α by shRNA increases the antiproliferative isoform of <jats:italic>C/EBP</jats:italic>α (p42<jats:sup>C/EBPα</jats:sup>). Furthermore, growth analysis revealed that these 2 isoforms yield very different proliferative properties in HNSCC. © 2008 Wiley‐Liss, Inc.</jats:p> Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42<sup>C/EBPα</sup>) in head and neck squamous cell carcinoma International Journal of Cancer |
| spellingShingle | Bennett, Kristi L., Romigh, Todd, Arab, Khelifa, Teresi, Rosemary E., Tada, Yasuhiro, Eng, Charis, Plass, Christoph, International Journal of Cancer, Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma, Cancer Research, Oncology |
| title | Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_full | Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_fullStr | Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_full_unstemmed | Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_short | Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| title_sort | activator protein 2 alpha (ap2α) suppresses 42 kda c/caat enhancer binding protein α (p42<sup>c/ebpα</sup>) in head and neck squamous cell carcinoma |
| title_unstemmed | Activator protein 2 alpha (AP2α) suppresses 42 kDa C/CAAT enhancer binding protein α (p42C/EBPα) in head and neck squamous cell carcinoma |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1002/ijc.24087 |