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Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors
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| Zeitschriftentitel: | International Journal of Cancer |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | International Journal of Cancer, 109, 2004, 3, S. 317-321 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Ghabreau, Lina Roux, Jean Paul Frappart, Pierre‐Olivier Mathevet, Patrice Patricot, Louis Marc Mokni, Moncef Korbi, Sadok Wang, Zhao‐Qi Tong, Wei‐Min Frappart, Lucien Ghabreau, Lina Roux, Jean Paul Frappart, Pierre‐Olivier Mathevet, Patrice Patricot, Louis Marc Mokni, Moncef Korbi, Sadok Wang, Zhao‐Qi Tong, Wei‐Min Frappart, Lucien |
|---|---|
| author |
Ghabreau, Lina Roux, Jean Paul Frappart, Pierre‐Olivier Mathevet, Patrice Patricot, Louis Marc Mokni, Moncef Korbi, Sadok Wang, Zhao‐Qi Tong, Wei‐Min Frappart, Lucien |
| spellingShingle |
Ghabreau, Lina Roux, Jean Paul Frappart, Pierre‐Olivier Mathevet, Patrice Patricot, Louis Marc Mokni, Moncef Korbi, Sadok Wang, Zhao‐Qi Tong, Wei‐Min Frappart, Lucien International Journal of Cancer Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors Cancer Research Oncology |
| author_sort |
ghabreau, lina |
| spelling |
Ghabreau, Lina Roux, Jean Paul Frappart, Pierre‐Olivier Mathevet, Patrice Patricot, Louis Marc Mokni, Moncef Korbi, Sadok Wang, Zhao‐Qi Tong, Wei‐Min Frappart, Lucien 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.11731 <jats:title>Abstract</jats:title><jats:p>Endometrial carcinomas are the most common malignancy of the female genital tract. Although the downregulation of the progesterone receptor (PR) in the progression of endometrioid carcinomas (ECs) has been well documented, the mechanism of PR alteration in endometrioid carcinogenesis is poorly understood. Recently, biochemical studies have shown that the DNA strand break‐sensing molecule poly(ADP‐ribose) polymerase (PARP‐1) was associated with the DNA binding domain of PR. In our present study, we show that in normal endometrial epithelium, the expression level of PARP‐1 protein is high in the proliferative phase but markedly decreases during the secretory phase. Interestingly, PARP‐1 expression gradually increases in nonatypical and atypical endometrial hyperplasia, reaching its highest level in grade I, and decreases significantly toward grade III ECs. Notably, PARP‐1 and PR expressions, in each stage, are positively correlated (<jats:italic>p</jats:italic> < 0.0001), with the exception of nonendometrioid carcinomas. Thus, these data suggest that PARP‐1 is substantially involved in the regulation of progesterone action in the development of ECs. © 2004 Wiley‐Liss, Inc.</jats:p> Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors International Journal of Cancer |
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Wiley, 2004 |
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Wiley, 2004 |
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0020-7136 1097-0215 |
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2004 |
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Wiley |
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International Journal of Cancer |
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| title |
Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_unstemmed |
Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_full |
Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_fullStr |
Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_full_unstemmed |
Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_short |
Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_sort |
poly(adp‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1002/ijc.11731 |
| publishDate |
2004 |
| physical |
317-321 |
| description |
<jats:title>Abstract</jats:title><jats:p>Endometrial carcinomas are the most common malignancy of the female genital tract. Although the downregulation of the progesterone receptor (PR) in the progression of endometrioid carcinomas (ECs) has been well documented, the mechanism of PR alteration in endometrioid carcinogenesis is poorly understood. Recently, biochemical studies have shown that the DNA strand break‐sensing molecule poly(ADP‐ribose) polymerase (PARP‐1) was associated with the DNA binding domain of PR. In our present study, we show that in normal endometrial epithelium, the expression level of PARP‐1 protein is high in the proliferative phase but markedly decreases during the secretory phase. Interestingly, PARP‐1 expression gradually increases in nonatypical and atypical endometrial hyperplasia, reaching its highest level in grade I, and decreases significantly toward grade III ECs. Notably, PARP‐1 and PR expressions, in each stage, are positively correlated (<jats:italic>p</jats:italic> < 0.0001), with the exception of nonendometrioid carcinomas. Thus, these data suggest that PARP‐1 is substantially involved in the regulation of progesterone action in the development of ECs. © 2004 Wiley‐Liss, Inc.</jats:p> |
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| author | Ghabreau, Lina, Roux, Jean Paul, Frappart, Pierre‐Olivier, Mathevet, Patrice, Patricot, Louis Marc, Mokni, Moncef, Korbi, Sadok, Wang, Zhao‐Qi, Tong, Wei‐Min, Frappart, Lucien |
| author_facet | Ghabreau, Lina, Roux, Jean Paul, Frappart, Pierre‐Olivier, Mathevet, Patrice, Patricot, Louis Marc, Mokni, Moncef, Korbi, Sadok, Wang, Zhao‐Qi, Tong, Wei‐Min, Frappart, Lucien, Ghabreau, Lina, Roux, Jean Paul, Frappart, Pierre‐Olivier, Mathevet, Patrice, Patricot, Louis Marc, Mokni, Moncef, Korbi, Sadok, Wang, Zhao‐Qi, Tong, Wei‐Min, Frappart, Lucien |
| author_sort | ghabreau, lina |
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| description | <jats:title>Abstract</jats:title><jats:p>Endometrial carcinomas are the most common malignancy of the female genital tract. Although the downregulation of the progesterone receptor (PR) in the progression of endometrioid carcinomas (ECs) has been well documented, the mechanism of PR alteration in endometrioid carcinogenesis is poorly understood. Recently, biochemical studies have shown that the DNA strand break‐sensing molecule poly(ADP‐ribose) polymerase (PARP‐1) was associated with the DNA binding domain of PR. In our present study, we show that in normal endometrial epithelium, the expression level of PARP‐1 protein is high in the proliferative phase but markedly decreases during the secretory phase. Interestingly, PARP‐1 expression gradually increases in nonatypical and atypical endometrial hyperplasia, reaching its highest level in grade I, and decreases significantly toward grade III ECs. Notably, PARP‐1 and PR expressions, in each stage, are positively correlated (<jats:italic>p</jats:italic> < 0.0001), with the exception of nonendometrioid carcinomas. Thus, these data suggest that PARP‐1 is substantially involved in the regulation of progesterone action in the development of ECs. © 2004 Wiley‐Liss, Inc.</jats:p> |
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| spelling | Ghabreau, Lina Roux, Jean Paul Frappart, Pierre‐Olivier Mathevet, Patrice Patricot, Louis Marc Mokni, Moncef Korbi, Sadok Wang, Zhao‐Qi Tong, Wei‐Min Frappart, Lucien 0020-7136 1097-0215 Wiley Cancer Research Oncology http://dx.doi.org/10.1002/ijc.11731 <jats:title>Abstract</jats:title><jats:p>Endometrial carcinomas are the most common malignancy of the female genital tract. Although the downregulation of the progesterone receptor (PR) in the progression of endometrioid carcinomas (ECs) has been well documented, the mechanism of PR alteration in endometrioid carcinogenesis is poorly understood. Recently, biochemical studies have shown that the DNA strand break‐sensing molecule poly(ADP‐ribose) polymerase (PARP‐1) was associated with the DNA binding domain of PR. In our present study, we show that in normal endometrial epithelium, the expression level of PARP‐1 protein is high in the proliferative phase but markedly decreases during the secretory phase. Interestingly, PARP‐1 expression gradually increases in nonatypical and atypical endometrial hyperplasia, reaching its highest level in grade I, and decreases significantly toward grade III ECs. Notably, PARP‐1 and PR expressions, in each stage, are positively correlated (<jats:italic>p</jats:italic> < 0.0001), with the exception of nonendometrioid carcinomas. Thus, these data suggest that PARP‐1 is substantially involved in the regulation of progesterone action in the development of ECs. © 2004 Wiley‐Liss, Inc.</jats:p> Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors International Journal of Cancer |
| spellingShingle | Ghabreau, Lina, Roux, Jean Paul, Frappart, Pierre‐Olivier, Mathevet, Patrice, Patricot, Louis Marc, Mokni, Moncef, Korbi, Sadok, Wang, Zhao‐Qi, Tong, Wei‐Min, Frappart, Lucien, International Journal of Cancer, Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors, Cancer Research, Oncology |
| title | Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_full | Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_fullStr | Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_full_unstemmed | Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_short | Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_sort | poly(adp‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| title_unstemmed | Poly(ADP‐ribose) polymerase‐1, a novel partner of progesterone receptors in endometrial cancer and its precursors |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1002/ijc.11731 |