Eintrag weiter verarbeiten
Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease
Gespeichert in:
| Zeitschriftentitel: | Hepatology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Hepatology, 67, 2018, 1, S. 123-133 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Estes, Chris Razavi, Homie Loomba, Rohit Younossi, Zobair Sanyal, Arun J. Estes, Chris Razavi, Homie Loomba, Rohit Younossi, Zobair Sanyal, Arun J. |
|---|---|
| author |
Estes, Chris Razavi, Homie Loomba, Rohit Younossi, Zobair Sanyal, Arun J. |
| spellingShingle |
Estes, Chris Razavi, Homie Loomba, Rohit Younossi, Zobair Sanyal, Arun J. Hepatology Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease Hepatology |
| author_sort |
estes, chris |
| spelling |
Estes, Chris Razavi, Homie Loomba, Rohit Younossi, Zobair Sanyal, Arun J. 0270-9139 1527-3350 Ovid Technologies (Wolters Kluwer Health) Hepatology http://dx.doi.org/10.1002/hep.29466 <jats:p>Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are highly prevalent in the United States, where they are a growing cause of cirrhosis and hepatocellular carcinoma (HCC) and increasingly an indicator for liver transplantation. A Markov model was used to forecast NAFLD disease progression. Incidence of NAFLD was based on historical and projected changes in adult prevalence of obesity and type 2 diabetes mellitus (DM). Assumptions were derived from published literature where available and validated using national surveillance data for incidence of NAFLD‐related HCC. Projected changes in NAFLD‐related cirrhosis, advanced liver disease, and liver‐related mortality were quantified through 2030. Prevalent NAFLD cases are forecasted to increase 21%, from 83.1 million (2015) to 100.9 million (2030), while prevalent NASH cases will increase 63% from 16.52 million to 27.00 million cases. Overall NAFLD prevalence among the adult population (aged ≥15 years) is projected at 33.5% in 2030, and the median age of the NAFLD population will increase from 50 to 55 years during 2015‐2030. In 2015, approximately 20% of NAFLD cases were classified as NASH, increasing to 27% by 2030, a reflection of both disease progression and an aging population. Incidence of decompensated cirrhosis will increase 168% to 105,430 cases by 2030, while incidence of HCC will increase by 137% to 12,240 cases. Liver deaths will increase 178% to an estimated 78,300 deaths in 2030. During 2015‐2030, there are projected to be nearly 800,000 excess liver deaths. <jats:italic toggle="yes">Conclusion:</jats:italic> With continued high rates of adult obesity and DM along with an aging population, NAFLD‐related liver disease and mortality will increase in the United States. Strategies to slow the growth of NAFLD cases and therapeutic options are necessary to mitigate disease burden. (H<jats:sc>epatology</jats:sc> 2018;67:123‐133).</jats:p> Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease Hepatology |
| doi_str_mv |
10.1002/hep.29466 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9oZXAuMjk0NjY |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9oZXAuMjk0NjY |
| institution |
DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-105 |
| imprint |
Ovid Technologies (Wolters Kluwer Health), 2018 |
| imprint_str_mv |
Ovid Technologies (Wolters Kluwer Health), 2018 |
| issn |
0270-9139 1527-3350 |
| issn_str_mv |
0270-9139 1527-3350 |
| language |
English |
| mega_collection |
Ovid Technologies (Wolters Kluwer Health) (CrossRef) |
| match_str |
estes2018modelingtheepidemicofnonalcoholicfattyliverdiseasedemonstratesanexponentialincreaseinburdenofdisease |
| publishDateSort |
2018 |
| publisher |
Ovid Technologies (Wolters Kluwer Health) |
| recordtype |
ai |
| record_format |
ai |
| series |
Hepatology |
| source_id |
49 |
| title |
Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_unstemmed |
Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_full |
Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_fullStr |
Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_full_unstemmed |
Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_short |
Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_sort |
modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| topic |
Hepatology |
| url |
http://dx.doi.org/10.1002/hep.29466 |
| publishDate |
2018 |
| physical |
123-133 |
| description |
<jats:p>Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are highly prevalent in the United States, where they are a growing cause of cirrhosis and hepatocellular carcinoma (HCC) and increasingly an indicator for liver transplantation. A Markov model was used to forecast NAFLD disease progression. Incidence of NAFLD was based on historical and projected changes in adult prevalence of obesity and type 2 diabetes mellitus (DM). Assumptions were derived from published literature where available and validated using national surveillance data for incidence of NAFLD‐related HCC. Projected changes in NAFLD‐related cirrhosis, advanced liver disease, and liver‐related mortality were quantified through 2030. Prevalent NAFLD cases are forecasted to increase 21%, from 83.1 million (2015) to 100.9 million (2030), while prevalent NASH cases will increase 63% from 16.52 million to 27.00 million cases. Overall NAFLD prevalence among the adult population (aged ≥15 years) is projected at 33.5% in 2030, and the median age of the NAFLD population will increase from 50 to 55 years during 2015‐2030. In 2015, approximately 20% of NAFLD cases were classified as NASH, increasing to 27% by 2030, a reflection of both disease progression and an aging population. Incidence of decompensated cirrhosis will increase 168% to 105,430 cases by 2030, while incidence of HCC will increase by 137% to 12,240 cases. Liver deaths will increase 178% to an estimated 78,300 deaths in 2030. During 2015‐2030, there are projected to be nearly 800,000 excess liver deaths. <jats:italic toggle="yes">Conclusion:</jats:italic> With continued high rates of adult obesity and DM along with an aging population, NAFLD‐related liver disease and mortality will increase in the United States. Strategies to slow the growth of NAFLD cases and therapeutic options are necessary to mitigate disease burden. (H<jats:sc>epatology</jats:sc> 2018;67:123‐133).</jats:p> |
| container_issue |
1 |
| container_start_page |
123 |
| container_title |
Hepatology |
| container_volume |
67 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792344031081005061 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:01:08.268Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Modeling+the+epidemic+of+nonalcoholic+fatty+liver+disease+demonstrates+an+exponential+increase+in+burden+of+disease&rft.date=2018-01-01&genre=article&issn=1527-3350&volume=67&issue=1&spage=123&epage=133&pages=123-133&jtitle=Hepatology&atitle=Modeling+the+epidemic+of+nonalcoholic+fatty+liver+disease+demonstrates+an+exponential+increase+in+burden+of+disease&aulast=Sanyal&aufirst=Arun+J.&rft_id=info%3Adoi%2F10.1002%2Fhep.29466&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792344031081005061 |
| author | Estes, Chris, Razavi, Homie, Loomba, Rohit, Younossi, Zobair, Sanyal, Arun J. |
| author_facet | Estes, Chris, Razavi, Homie, Loomba, Rohit, Younossi, Zobair, Sanyal, Arun J., Estes, Chris, Razavi, Homie, Loomba, Rohit, Younossi, Zobair, Sanyal, Arun J. |
| author_sort | estes, chris |
| container_issue | 1 |
| container_start_page | 123 |
| container_title | Hepatology |
| container_volume | 67 |
| description | <jats:p>Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are highly prevalent in the United States, where they are a growing cause of cirrhosis and hepatocellular carcinoma (HCC) and increasingly an indicator for liver transplantation. A Markov model was used to forecast NAFLD disease progression. Incidence of NAFLD was based on historical and projected changes in adult prevalence of obesity and type 2 diabetes mellitus (DM). Assumptions were derived from published literature where available and validated using national surveillance data for incidence of NAFLD‐related HCC. Projected changes in NAFLD‐related cirrhosis, advanced liver disease, and liver‐related mortality were quantified through 2030. Prevalent NAFLD cases are forecasted to increase 21%, from 83.1 million (2015) to 100.9 million (2030), while prevalent NASH cases will increase 63% from 16.52 million to 27.00 million cases. Overall NAFLD prevalence among the adult population (aged ≥15 years) is projected at 33.5% in 2030, and the median age of the NAFLD population will increase from 50 to 55 years during 2015‐2030. In 2015, approximately 20% of NAFLD cases were classified as NASH, increasing to 27% by 2030, a reflection of both disease progression and an aging population. Incidence of decompensated cirrhosis will increase 168% to 105,430 cases by 2030, while incidence of HCC will increase by 137% to 12,240 cases. Liver deaths will increase 178% to an estimated 78,300 deaths in 2030. During 2015‐2030, there are projected to be nearly 800,000 excess liver deaths. <jats:italic toggle="yes">Conclusion:</jats:italic> With continued high rates of adult obesity and DM along with an aging population, NAFLD‐related liver disease and mortality will increase in the United States. Strategies to slow the growth of NAFLD cases and therapeutic options are necessary to mitigate disease burden. (H<jats:sc>epatology</jats:sc> 2018;67:123‐133).</jats:p> |
| doi_str_mv | 10.1002/hep.29466 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9oZXAuMjk0NjY |
| imprint | Ovid Technologies (Wolters Kluwer Health), 2018 |
| imprint_str_mv | Ovid Technologies (Wolters Kluwer Health), 2018 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105 |
| issn | 0270-9139, 1527-3350 |
| issn_str_mv | 0270-9139, 1527-3350 |
| language | English |
| last_indexed | 2024-03-01T17:01:08.268Z |
| match_str | estes2018modelingtheepidemicofnonalcoholicfattyliverdiseasedemonstratesanexponentialincreaseinburdenofdisease |
| mega_collection | Ovid Technologies (Wolters Kluwer Health) (CrossRef) |
| physical | 123-133 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | Ovid Technologies (Wolters Kluwer Health) |
| record_format | ai |
| recordtype | ai |
| series | Hepatology |
| source_id | 49 |
| spelling | Estes, Chris Razavi, Homie Loomba, Rohit Younossi, Zobair Sanyal, Arun J. 0270-9139 1527-3350 Ovid Technologies (Wolters Kluwer Health) Hepatology http://dx.doi.org/10.1002/hep.29466 <jats:p>Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are highly prevalent in the United States, where they are a growing cause of cirrhosis and hepatocellular carcinoma (HCC) and increasingly an indicator for liver transplantation. A Markov model was used to forecast NAFLD disease progression. Incidence of NAFLD was based on historical and projected changes in adult prevalence of obesity and type 2 diabetes mellitus (DM). Assumptions were derived from published literature where available and validated using national surveillance data for incidence of NAFLD‐related HCC. Projected changes in NAFLD‐related cirrhosis, advanced liver disease, and liver‐related mortality were quantified through 2030. Prevalent NAFLD cases are forecasted to increase 21%, from 83.1 million (2015) to 100.9 million (2030), while prevalent NASH cases will increase 63% from 16.52 million to 27.00 million cases. Overall NAFLD prevalence among the adult population (aged ≥15 years) is projected at 33.5% in 2030, and the median age of the NAFLD population will increase from 50 to 55 years during 2015‐2030. In 2015, approximately 20% of NAFLD cases were classified as NASH, increasing to 27% by 2030, a reflection of both disease progression and an aging population. Incidence of decompensated cirrhosis will increase 168% to 105,430 cases by 2030, while incidence of HCC will increase by 137% to 12,240 cases. Liver deaths will increase 178% to an estimated 78,300 deaths in 2030. During 2015‐2030, there are projected to be nearly 800,000 excess liver deaths. <jats:italic toggle="yes">Conclusion:</jats:italic> With continued high rates of adult obesity and DM along with an aging population, NAFLD‐related liver disease and mortality will increase in the United States. Strategies to slow the growth of NAFLD cases and therapeutic options are necessary to mitigate disease burden. (H<jats:sc>epatology</jats:sc> 2018;67:123‐133).</jats:p> Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease Hepatology |
| spellingShingle | Estes, Chris, Razavi, Homie, Loomba, Rohit, Younossi, Zobair, Sanyal, Arun J., Hepatology, Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease, Hepatology |
| title | Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_full | Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_fullStr | Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_full_unstemmed | Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_short | Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_sort | modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| title_unstemmed | Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease |
| topic | Hepatology |
| url | http://dx.doi.org/10.1002/hep.29466 |