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Subcortical structural variations associated with low socioeconomic status in adolescents
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| Zeitschriftentitel: | Human Brain Mapping |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Human Brain Mapping, 41, 2020, 1, S. 162-171 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Jenkins, Lisanne M. Chiang, Jessica J. Vause, Katherine Hoffer, Lauren Alpert, Kathryn Parrish, Todd B. Wang, Lei Miller, Gregory E. Jenkins, Lisanne M. Chiang, Jessica J. Vause, Katherine Hoffer, Lauren Alpert, Kathryn Parrish, Todd B. Wang, Lei Miller, Gregory E. |
|---|---|
| author |
Jenkins, Lisanne M. Chiang, Jessica J. Vause, Katherine Hoffer, Lauren Alpert, Kathryn Parrish, Todd B. Wang, Lei Miller, Gregory E. |
| spellingShingle |
Jenkins, Lisanne M. Chiang, Jessica J. Vause, Katherine Hoffer, Lauren Alpert, Kathryn Parrish, Todd B. Wang, Lei Miller, Gregory E. Human Brain Mapping Subcortical structural variations associated with low socioeconomic status in adolescents Neurology (clinical) Neurology Radiology, Nuclear Medicine and imaging Radiological and Ultrasound Technology Anatomy |
| author_sort |
jenkins, lisanne m. |
| spelling |
Jenkins, Lisanne M. Chiang, Jessica J. Vause, Katherine Hoffer, Lauren Alpert, Kathryn Parrish, Todd B. Wang, Lei Miller, Gregory E. 1065-9471 1097-0193 Wiley Neurology (clinical) Neurology Radiology, Nuclear Medicine and imaging Radiological and Ultrasound Technology Anatomy http://dx.doi.org/10.1002/hbm.24796 <jats:title>Abstract</jats:title><jats:p>Low socioeconomic status (SES) is associated with a higher probability of multiple exposures (e.g., neighborhood violence, poor nutrition, housing instability, air pollution, and insensitive caregiving) known to affect structural development of subcortical brain regions that subserve threat and reward processing, however, few studies have examined the relationship between SES and such subcortical structures in adolescents. We examined SES variations in volume and surface morphometry of subcortical regions. The sample comprised 256 youth in eighth grade (mean age = 13.9 years), in whom high dimensional deformation mapping of structural 3T magnetic resonance imaging scans was performed. Vertex‐wise linear regression analyses examined associations between income to poverty ratio and surfaces of the hippocampus, amygdala, thalamus, caudate, putamen, nucleus accumbens and pallidum, with the covariates age, pubertal status, and intracranial volume. Given sex differences in pubertal development and subcortical maturation at this age, the analyses were stratified by sex. Among males, who at this age average an earlier pubertal stage than females, the relationship between SES and local shape variation in subcortical regions was almost entirely positive. For females, the relationship between SES and local shape variation was negative. Racial identity was associated with SES in our sample, however supplementary analyses indicated that most of the associations between SES and subcortical structure were independent of it. Although these cross‐sectional results are not definitive, they are consistent with a scenario where low SES delays structural maturation of subcortical regions involved with threat and reward processing. Future longitudinal studies are needed to test this hypothesis.</jats:p> Subcortical structural variations associated with low socioeconomic status in adolescents Human Brain Mapping |
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Subcortical structural variations associated with low socioeconomic status in adolescents |
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Subcortical structural variations associated with low socioeconomic status in adolescents |
| title_full |
Subcortical structural variations associated with low socioeconomic status in adolescents |
| title_fullStr |
Subcortical structural variations associated with low socioeconomic status in adolescents |
| title_full_unstemmed |
Subcortical structural variations associated with low socioeconomic status in adolescents |
| title_short |
Subcortical structural variations associated with low socioeconomic status in adolescents |
| title_sort |
subcortical structural variations associated with low socioeconomic status in adolescents |
| topic |
Neurology (clinical) Neurology Radiology, Nuclear Medicine and imaging Radiological and Ultrasound Technology Anatomy |
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http://dx.doi.org/10.1002/hbm.24796 |
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2020 |
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162-171 |
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<jats:title>Abstract</jats:title><jats:p>Low socioeconomic status (SES) is associated with a higher probability of multiple exposures (e.g., neighborhood violence, poor nutrition, housing instability, air pollution, and insensitive caregiving) known to affect structural development of subcortical brain regions that subserve threat and reward processing, however, few studies have examined the relationship between SES and such subcortical structures in adolescents. We examined SES variations in volume and surface morphometry of subcortical regions. The sample comprised 256 youth in eighth grade (mean age = 13.9 years), in whom high dimensional deformation mapping of structural 3T magnetic resonance imaging scans was performed. Vertex‐wise linear regression analyses examined associations between income to poverty ratio and surfaces of the hippocampus, amygdala, thalamus, caudate, putamen, nucleus accumbens and pallidum, with the covariates age, pubertal status, and intracranial volume. Given sex differences in pubertal development and subcortical maturation at this age, the analyses were stratified by sex. Among males, who at this age average an earlier pubertal stage than females, the relationship between SES and local shape variation in subcortical regions was almost entirely positive. For females, the relationship between SES and local shape variation was negative. Racial identity was associated with SES in our sample, however supplementary analyses indicated that most of the associations between SES and subcortical structure were independent of it. Although these cross‐sectional results are not definitive, they are consistent with a scenario where low SES delays structural maturation of subcortical regions involved with threat and reward processing. Future longitudinal studies are needed to test this hypothesis.</jats:p> |
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| author | Jenkins, Lisanne M., Chiang, Jessica J., Vause, Katherine, Hoffer, Lauren, Alpert, Kathryn, Parrish, Todd B., Wang, Lei, Miller, Gregory E. |
| author_facet | Jenkins, Lisanne M., Chiang, Jessica J., Vause, Katherine, Hoffer, Lauren, Alpert, Kathryn, Parrish, Todd B., Wang, Lei, Miller, Gregory E., Jenkins, Lisanne M., Chiang, Jessica J., Vause, Katherine, Hoffer, Lauren, Alpert, Kathryn, Parrish, Todd B., Wang, Lei, Miller, Gregory E. |
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| description | <jats:title>Abstract</jats:title><jats:p>Low socioeconomic status (SES) is associated with a higher probability of multiple exposures (e.g., neighborhood violence, poor nutrition, housing instability, air pollution, and insensitive caregiving) known to affect structural development of subcortical brain regions that subserve threat and reward processing, however, few studies have examined the relationship between SES and such subcortical structures in adolescents. We examined SES variations in volume and surface morphometry of subcortical regions. The sample comprised 256 youth in eighth grade (mean age = 13.9 years), in whom high dimensional deformation mapping of structural 3T magnetic resonance imaging scans was performed. Vertex‐wise linear regression analyses examined associations between income to poverty ratio and surfaces of the hippocampus, amygdala, thalamus, caudate, putamen, nucleus accumbens and pallidum, with the covariates age, pubertal status, and intracranial volume. Given sex differences in pubertal development and subcortical maturation at this age, the analyses were stratified by sex. Among males, who at this age average an earlier pubertal stage than females, the relationship between SES and local shape variation in subcortical regions was almost entirely positive. For females, the relationship between SES and local shape variation was negative. Racial identity was associated with SES in our sample, however supplementary analyses indicated that most of the associations between SES and subcortical structure were independent of it. Although these cross‐sectional results are not definitive, they are consistent with a scenario where low SES delays structural maturation of subcortical regions involved with threat and reward processing. Future longitudinal studies are needed to test this hypothesis.</jats:p> |
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| spelling | Jenkins, Lisanne M. Chiang, Jessica J. Vause, Katherine Hoffer, Lauren Alpert, Kathryn Parrish, Todd B. Wang, Lei Miller, Gregory E. 1065-9471 1097-0193 Wiley Neurology (clinical) Neurology Radiology, Nuclear Medicine and imaging Radiological and Ultrasound Technology Anatomy http://dx.doi.org/10.1002/hbm.24796 <jats:title>Abstract</jats:title><jats:p>Low socioeconomic status (SES) is associated with a higher probability of multiple exposures (e.g., neighborhood violence, poor nutrition, housing instability, air pollution, and insensitive caregiving) known to affect structural development of subcortical brain regions that subserve threat and reward processing, however, few studies have examined the relationship between SES and such subcortical structures in adolescents. We examined SES variations in volume and surface morphometry of subcortical regions. The sample comprised 256 youth in eighth grade (mean age = 13.9 years), in whom high dimensional deformation mapping of structural 3T magnetic resonance imaging scans was performed. Vertex‐wise linear regression analyses examined associations between income to poverty ratio and surfaces of the hippocampus, amygdala, thalamus, caudate, putamen, nucleus accumbens and pallidum, with the covariates age, pubertal status, and intracranial volume. Given sex differences in pubertal development and subcortical maturation at this age, the analyses were stratified by sex. Among males, who at this age average an earlier pubertal stage than females, the relationship between SES and local shape variation in subcortical regions was almost entirely positive. For females, the relationship between SES and local shape variation was negative. Racial identity was associated with SES in our sample, however supplementary analyses indicated that most of the associations between SES and subcortical structure were independent of it. Although these cross‐sectional results are not definitive, they are consistent with a scenario where low SES delays structural maturation of subcortical regions involved with threat and reward processing. Future longitudinal studies are needed to test this hypothesis.</jats:p> Subcortical structural variations associated with low socioeconomic status in adolescents Human Brain Mapping |
| spellingShingle | Jenkins, Lisanne M., Chiang, Jessica J., Vause, Katherine, Hoffer, Lauren, Alpert, Kathryn, Parrish, Todd B., Wang, Lei, Miller, Gregory E., Human Brain Mapping, Subcortical structural variations associated with low socioeconomic status in adolescents, Neurology (clinical), Neurology, Radiology, Nuclear Medicine and imaging, Radiological and Ultrasound Technology, Anatomy |
| title | Subcortical structural variations associated with low socioeconomic status in adolescents |
| title_full | Subcortical structural variations associated with low socioeconomic status in adolescents |
| title_fullStr | Subcortical structural variations associated with low socioeconomic status in adolescents |
| title_full_unstemmed | Subcortical structural variations associated with low socioeconomic status in adolescents |
| title_short | Subcortical structural variations associated with low socioeconomic status in adolescents |
| title_sort | subcortical structural variations associated with low socioeconomic status in adolescents |
| title_unstemmed | Subcortical structural variations associated with low socioeconomic status in adolescents |
| topic | Neurology (clinical), Neurology, Radiology, Nuclear Medicine and imaging, Radiological and Ultrasound Technology, Anatomy |
| url | http://dx.doi.org/10.1002/hbm.24796 |