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The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis
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| Zeitschriftentitel: | EMBO Molecular Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | EMBO Molecular Medicine, 4, 2012, 1, S. 38-51 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Springer Science and Business Media LLC
|
| Schlagwörter: |
| author_facet |
Augustin, Iris Goidts, Violaine Bongers, Angelika Kerr, Grainne Vollert, Gordon Radlwimmer, Bernhard Hartmann, Christian Herold‐Mende, Christel Reifenberger, Guido von Deimling, Andreas Boutros, Michael Augustin, Iris Goidts, Violaine Bongers, Angelika Kerr, Grainne Vollert, Gordon Radlwimmer, Bernhard Hartmann, Christian Herold‐Mende, Christel Reifenberger, Guido von Deimling, Andreas Boutros, Michael |
|---|---|
| author |
Augustin, Iris Goidts, Violaine Bongers, Angelika Kerr, Grainne Vollert, Gordon Radlwimmer, Bernhard Hartmann, Christian Herold‐Mende, Christel Reifenberger, Guido von Deimling, Andreas Boutros, Michael |
| spellingShingle |
Augustin, Iris Goidts, Violaine Bongers, Angelika Kerr, Grainne Vollert, Gordon Radlwimmer, Bernhard Hartmann, Christian Herold‐Mende, Christel Reifenberger, Guido von Deimling, Andreas Boutros, Michael EMBO Molecular Medicine The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis Molecular Medicine |
| author_sort |
augustin, iris |
| spelling |
Augustin, Iris Goidts, Violaine Bongers, Angelika Kerr, Grainne Vollert, Gordon Radlwimmer, Bernhard Hartmann, Christian Herold‐Mende, Christel Reifenberger, Guido von Deimling, Andreas Boutros, Michael 1757-4676 1757-4684 Springer Science and Business Media LLC Molecular Medicine http://dx.doi.org/10.1002/emmm.201100186 <jats:title>Abstract</jats:title><jats:p>Malignant astrocytomas are highly aggressive brain tumours with poor prognosis. While a number of structural genomic changes and dysregulation of signalling pathways in gliomas have been described, the identification of biomarkers and druggable targets remains an important task for novel diagnostic and therapeutic approaches. Here, we show that the Wnt‐specific secretory protein Evi (also known as GPR177/Wntless/Sprinter) is overexpressed in astrocytic gliomas. Evi/Wls is a core Wnt signalling component and a specific regulator of pan‐Wnt protein secretion, affecting both canonical and non‐canonical signalling. We demonstrate that its depletion in glioma and glioma‐derived stem‐like cells led to decreased cell proliferation and apoptosis. Furthermore, Evi/Wls silencing in glioma cells reduced cell migration and the capacity to form tumours <jats:italic>in vivo</jats:italic>. We further show that Evi/Wls overexpression is sufficient to promote downstream Wnt signalling. Taken together, our study identifies Evi/Wls as an essential regulator of glioma tumourigenesis, identifying a pathway‐specific protein trafficking factor as an oncogene and offering novel therapeutic options to interfere with the aberrant regulation of growth factors at the site of production.</jats:p> The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis EMBO Molecular Medicine |
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EMBO Molecular Medicine |
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| title |
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_unstemmed |
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_full |
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_fullStr |
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_full_unstemmed |
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_short |
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_sort |
the wnt secretion protein evi/gpr177 promotes glioma tumourigenesis |
| topic |
Molecular Medicine |
| url |
http://dx.doi.org/10.1002/emmm.201100186 |
| publishDate |
2012 |
| physical |
38-51 |
| description |
<jats:title>Abstract</jats:title><jats:p>Malignant astrocytomas are highly aggressive brain tumours with poor prognosis. While a number of structural genomic changes and dysregulation of signalling pathways in gliomas have been described, the identification of biomarkers and druggable targets remains an important task for novel diagnostic and therapeutic approaches. Here, we show that the Wnt‐specific secretory protein Evi (also known as GPR177/Wntless/Sprinter) is overexpressed in astrocytic gliomas. Evi/Wls is a core Wnt signalling component and a specific regulator of pan‐Wnt protein secretion, affecting both canonical and non‐canonical signalling. We demonstrate that its depletion in glioma and glioma‐derived stem‐like cells led to decreased cell proliferation and apoptosis. Furthermore, Evi/Wls silencing in glioma cells reduced cell migration and the capacity to form tumours <jats:italic>in vivo</jats:italic>. We further show that Evi/Wls overexpression is sufficient to promote downstream Wnt signalling. Taken together, our study identifies Evi/Wls as an essential regulator of glioma tumourigenesis, identifying a pathway‐specific protein trafficking factor as an oncogene and offering novel therapeutic options to interfere with the aberrant regulation of growth factors at the site of production.</jats:p> |
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| author | Augustin, Iris, Goidts, Violaine, Bongers, Angelika, Kerr, Grainne, Vollert, Gordon, Radlwimmer, Bernhard, Hartmann, Christian, Herold‐Mende, Christel, Reifenberger, Guido, von Deimling, Andreas, Boutros, Michael |
| author_facet | Augustin, Iris, Goidts, Violaine, Bongers, Angelika, Kerr, Grainne, Vollert, Gordon, Radlwimmer, Bernhard, Hartmann, Christian, Herold‐Mende, Christel, Reifenberger, Guido, von Deimling, Andreas, Boutros, Michael, Augustin, Iris, Goidts, Violaine, Bongers, Angelika, Kerr, Grainne, Vollert, Gordon, Radlwimmer, Bernhard, Hartmann, Christian, Herold‐Mende, Christel, Reifenberger, Guido, von Deimling, Andreas, Boutros, Michael |
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| description | <jats:title>Abstract</jats:title><jats:p>Malignant astrocytomas are highly aggressive brain tumours with poor prognosis. While a number of structural genomic changes and dysregulation of signalling pathways in gliomas have been described, the identification of biomarkers and druggable targets remains an important task for novel diagnostic and therapeutic approaches. Here, we show that the Wnt‐specific secretory protein Evi (also known as GPR177/Wntless/Sprinter) is overexpressed in astrocytic gliomas. Evi/Wls is a core Wnt signalling component and a specific regulator of pan‐Wnt protein secretion, affecting both canonical and non‐canonical signalling. We demonstrate that its depletion in glioma and glioma‐derived stem‐like cells led to decreased cell proliferation and apoptosis. Furthermore, Evi/Wls silencing in glioma cells reduced cell migration and the capacity to form tumours <jats:italic>in vivo</jats:italic>. We further show that Evi/Wls overexpression is sufficient to promote downstream Wnt signalling. Taken together, our study identifies Evi/Wls as an essential regulator of glioma tumourigenesis, identifying a pathway‐specific protein trafficking factor as an oncogene and offering novel therapeutic options to interfere with the aberrant regulation of growth factors at the site of production.</jats:p> |
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| spelling | Augustin, Iris Goidts, Violaine Bongers, Angelika Kerr, Grainne Vollert, Gordon Radlwimmer, Bernhard Hartmann, Christian Herold‐Mende, Christel Reifenberger, Guido von Deimling, Andreas Boutros, Michael 1757-4676 1757-4684 Springer Science and Business Media LLC Molecular Medicine http://dx.doi.org/10.1002/emmm.201100186 <jats:title>Abstract</jats:title><jats:p>Malignant astrocytomas are highly aggressive brain tumours with poor prognosis. While a number of structural genomic changes and dysregulation of signalling pathways in gliomas have been described, the identification of biomarkers and druggable targets remains an important task for novel diagnostic and therapeutic approaches. Here, we show that the Wnt‐specific secretory protein Evi (also known as GPR177/Wntless/Sprinter) is overexpressed in astrocytic gliomas. Evi/Wls is a core Wnt signalling component and a specific regulator of pan‐Wnt protein secretion, affecting both canonical and non‐canonical signalling. We demonstrate that its depletion in glioma and glioma‐derived stem‐like cells led to decreased cell proliferation and apoptosis. Furthermore, Evi/Wls silencing in glioma cells reduced cell migration and the capacity to form tumours <jats:italic>in vivo</jats:italic>. We further show that Evi/Wls overexpression is sufficient to promote downstream Wnt signalling. Taken together, our study identifies Evi/Wls as an essential regulator of glioma tumourigenesis, identifying a pathway‐specific protein trafficking factor as an oncogene and offering novel therapeutic options to interfere with the aberrant regulation of growth factors at the site of production.</jats:p> The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis EMBO Molecular Medicine |
| spellingShingle | Augustin, Iris, Goidts, Violaine, Bongers, Angelika, Kerr, Grainne, Vollert, Gordon, Radlwimmer, Bernhard, Hartmann, Christian, Herold‐Mende, Christel, Reifenberger, Guido, von Deimling, Andreas, Boutros, Michael, EMBO Molecular Medicine, The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis, Molecular Medicine |
| title | The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_full | The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_fullStr | The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_full_unstemmed | The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_short | The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| title_sort | the wnt secretion protein evi/gpr177 promotes glioma tumourigenesis |
| title_unstemmed | The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis |
| topic | Molecular Medicine |
| url | http://dx.doi.org/10.1002/emmm.201100186 |