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Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells
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| Zeitschriftentitel: | Developmental Dynamics |
|---|---|
| Personen und Körperschaften: | , |
| In: | Developmental Dynamics, 240, 2011, 5, S. 1203-1211 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Roselló‐Díez, Alberto Torres, Miguel Roselló‐Díez, Alberto Torres, Miguel |
|---|---|
| author |
Roselló‐Díez, Alberto Torres, Miguel |
| spellingShingle |
Roselló‐Díez, Alberto Torres, Miguel Developmental Dynamics Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells Developmental Biology |
| author_sort |
roselló‐díez, alberto |
| spelling |
Roselló‐Díez, Alberto Torres, Miguel 1058-8388 1097-0177 Wiley Developmental Biology http://dx.doi.org/10.1002/dvdy.22635 <jats:title>Abstract</jats:title><jats:p>We have used the chick limb as a model to gain insight into the longstanding question of regulative vs. mosaic development. To test the influence of signals on limb proximodistal development, distal limb bud tips of several stages were grafted to regions of the embryo known to provide different signaling environments. Of interest, thin grafts (100‐micron thick) formed elements more proximal in character when grafted to the proximal limb region than when grafted to other regions. The extra elements were derived from host tissue, presumably distalized and recruited by the graft's apical ectodermal ridge signals. The results of classic and recent experiments have been reinterpreted in light of our conclusions. Developmental Dynamics 240:1203–1211, 2011. © 2011 Wiley‐Liss, Inc.</jats:p> Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells Developmental Dynamics |
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Wiley, 2011 |
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| title |
Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_unstemmed |
Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_full |
Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_fullStr |
Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_full_unstemmed |
Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_short |
Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_sort |
regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| topic |
Developmental Biology |
| url |
http://dx.doi.org/10.1002/dvdy.22635 |
| publishDate |
2011 |
| physical |
1203-1211 |
| description |
<jats:title>Abstract</jats:title><jats:p>We have used the chick limb as a model to gain insight into the longstanding question of regulative vs. mosaic development. To test the influence of signals on limb proximodistal development, distal limb bud tips of several stages were grafted to regions of the embryo known to provide different signaling environments. Of interest, thin grafts (100‐micron thick) formed elements more proximal in character when grafted to the proximal limb region than when grafted to other regions. The extra elements were derived from host tissue, presumably distalized and recruited by the graft's apical ectodermal ridge signals. The results of classic and recent experiments have been reinterpreted in light of our conclusions. Developmental Dynamics 240:1203–1211, 2011. © 2011 Wiley‐Liss, Inc.</jats:p> |
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| author | Roselló‐Díez, Alberto, Torres, Miguel |
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| description | <jats:title>Abstract</jats:title><jats:p>We have used the chick limb as a model to gain insight into the longstanding question of regulative vs. mosaic development. To test the influence of signals on limb proximodistal development, distal limb bud tips of several stages were grafted to regions of the embryo known to provide different signaling environments. Of interest, thin grafts (100‐micron thick) formed elements more proximal in character when grafted to the proximal limb region than when grafted to other regions. The extra elements were derived from host tissue, presumably distalized and recruited by the graft's apical ectodermal ridge signals. The results of classic and recent experiments have been reinterpreted in light of our conclusions. Developmental Dynamics 240:1203–1211, 2011. © 2011 Wiley‐Liss, Inc.</jats:p> |
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| source_id | 49 |
| spelling | Roselló‐Díez, Alberto Torres, Miguel 1058-8388 1097-0177 Wiley Developmental Biology http://dx.doi.org/10.1002/dvdy.22635 <jats:title>Abstract</jats:title><jats:p>We have used the chick limb as a model to gain insight into the longstanding question of regulative vs. mosaic development. To test the influence of signals on limb proximodistal development, distal limb bud tips of several stages were grafted to regions of the embryo known to provide different signaling environments. Of interest, thin grafts (100‐micron thick) formed elements more proximal in character when grafted to the proximal limb region than when grafted to other regions. The extra elements were derived from host tissue, presumably distalized and recruited by the graft's apical ectodermal ridge signals. The results of classic and recent experiments have been reinterpreted in light of our conclusions. Developmental Dynamics 240:1203–1211, 2011. © 2011 Wiley‐Liss, Inc.</jats:p> Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells Developmental Dynamics |
| spellingShingle | Roselló‐Díez, Alberto, Torres, Miguel, Developmental Dynamics, Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells, Developmental Biology |
| title | Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_full | Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_fullStr | Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_full_unstemmed | Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_short | Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_sort | regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| title_unstemmed | Regulative patterning in limb bud transplants is induced by distalizing activity of apical ectodermal ridge signals on host limb cells |
| topic | Developmental Biology |
| url | http://dx.doi.org/10.1002/dvdy.22635 |