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Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches
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| Zeitschriftentitel: | Arthritis & Rheumatism |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Arthritis & Rheumatism, 54, 2006, 3, S. 1009-1019 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Finis, Katharina Sültmann, Holger Ruschhaupt, Markus Buness, Andreas Helmchen, Birgit Kuner, Ruprecht Gross, Marie‐Luise Fink, Bernd Schirmacher, Peter Poustka, Annemarie Berger, Irina Finis, Katharina Sültmann, Holger Ruschhaupt, Markus Buness, Andreas Helmchen, Birgit Kuner, Ruprecht Gross, Marie‐Luise Fink, Bernd Schirmacher, Peter Poustka, Annemarie Berger, Irina |
|---|---|
| author |
Finis, Katharina Sültmann, Holger Ruschhaupt, Markus Buness, Andreas Helmchen, Birgit Kuner, Ruprecht Gross, Marie‐Luise Fink, Bernd Schirmacher, Peter Poustka, Annemarie Berger, Irina |
| spellingShingle |
Finis, Katharina Sültmann, Holger Ruschhaupt, Markus Buness, Andreas Helmchen, Birgit Kuner, Ruprecht Gross, Marie‐Luise Fink, Bernd Schirmacher, Peter Poustka, Annemarie Berger, Irina Arthritis & Rheumatism Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| author_sort |
finis, katharina |
| spelling |
Finis, Katharina Sültmann, Holger Ruschhaupt, Markus Buness, Andreas Helmchen, Birgit Kuner, Ruprecht Gross, Marie‐Luise Fink, Bernd Schirmacher, Peter Poustka, Annemarie Berger, Irina 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.21641 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To characterize the gene expression profile and determine potential diagnostic markers and therapeutic targets in pigmented villonodular synovitis (PVNS).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Gene expression patterns in 11 patients with PVNS, 18 patients with rheumatoid arthritis (RA), and 19 patients with osteoarthritis (OA) were investigated using genome‐wide complementary DNA microarrays. Validation of differentially expressed genes was performed by real‐time quantitative polymerase chain reaction and immunohistochemical analysis on tissue arrays (80 patients with PVNS, 51 patients with RA, and 20 patients with OA).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The gene expression profile in PVNS was clearly distinct from those in RA and OA. One hundred forty‐one up‐regulated genes and 47 down‐regulated genes were found in PVNS compared with RA, and 153 up‐regulated genes and 89 down‐regulated genes were found in PVNS compared with OA (fold change ≥1.5;<jats:italic>Q</jats:italic>≤ 0.001). Genes differentially expressed in PVNS were involved in apoptosis regulation, matrix degradation, and inflammation (<jats:italic>ALOX5AP</jats:italic>,<jats:italic>ATP6V1B2</jats:italic>,<jats:italic>CD53</jats:italic>,<jats:italic>CHI3L1</jats:italic>,<jats:italic>CTSL</jats:italic>,<jats:italic>CXCR4</jats:italic>,<jats:italic>HSPA8</jats:italic>,<jats:italic>HSPCA</jats:italic>,<jats:italic>LAPTM5</jats:italic>,<jats:italic>MMP9</jats:italic>,<jats:italic>MOAP1</jats:italic>, and<jats:italic>SPP1</jats:italic>).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The gene expression signature in PVNS is similar to that of activated macrophages and is consistent with the local destructive course of the disease. The gene and protein expression patterns suggest that the ongoing proliferation in PVNS is sustained by apoptosis resistance. This result suggests the possibility of a potential novel therapeutic intervention against PVNS.</jats:p></jats:sec> Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches Arthritis & Rheumatism |
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10.1002/art.21641 |
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Online Free |
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Chemie und Pharmazie Medizin |
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ElectronicArticle |
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Wiley, 2006 |
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Wiley, 2006 |
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0004-3591 1529-0131 |
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0004-3591 1529-0131 |
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finis2006analysisofpigmentedvillonodularsynovitiswithgenomewidecomplementarydnamicroarrayandtissuearraytechnologyrevealsinsightintopotentialnoveltherapeuticapproaches |
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Arthritis & Rheumatism |
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| title |
Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_unstemmed |
Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_full |
Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_fullStr |
Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_full_unstemmed |
Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_short |
Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_sort |
analysis of pigmented villonodular synovitis with genome‐wide complementary dna microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| topic |
Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| url |
http://dx.doi.org/10.1002/art.21641 |
| publishDate |
2006 |
| physical |
1009-1019 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To characterize the gene expression profile and determine potential diagnostic markers and therapeutic targets in pigmented villonodular synovitis (PVNS).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Gene expression patterns in 11 patients with PVNS, 18 patients with rheumatoid arthritis (RA), and 19 patients with osteoarthritis (OA) were investigated using genome‐wide complementary DNA microarrays. Validation of differentially expressed genes was performed by real‐time quantitative polymerase chain reaction and immunohistochemical analysis on tissue arrays (80 patients with PVNS, 51 patients with RA, and 20 patients with OA).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The gene expression profile in PVNS was clearly distinct from those in RA and OA. One hundred forty‐one up‐regulated genes and 47 down‐regulated genes were found in PVNS compared with RA, and 153 up‐regulated genes and 89 down‐regulated genes were found in PVNS compared with OA (fold change ≥1.5;<jats:italic>Q</jats:italic>≤ 0.001). Genes differentially expressed in PVNS were involved in apoptosis regulation, matrix degradation, and inflammation (<jats:italic>ALOX5AP</jats:italic>,<jats:italic>ATP6V1B2</jats:italic>,<jats:italic>CD53</jats:italic>,<jats:italic>CHI3L1</jats:italic>,<jats:italic>CTSL</jats:italic>,<jats:italic>CXCR4</jats:italic>,<jats:italic>HSPA8</jats:italic>,<jats:italic>HSPCA</jats:italic>,<jats:italic>LAPTM5</jats:italic>,<jats:italic>MMP9</jats:italic>,<jats:italic>MOAP1</jats:italic>, and<jats:italic>SPP1</jats:italic>).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The gene expression signature in PVNS is similar to that of activated macrophages and is consistent with the local destructive course of the disease. The gene and protein expression patterns suggest that the ongoing proliferation in PVNS is sustained by apoptosis resistance. This result suggests the possibility of a potential novel therapeutic intervention against PVNS.</jats:p></jats:sec> |
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| author | Finis, Katharina, Sültmann, Holger, Ruschhaupt, Markus, Buness, Andreas, Helmchen, Birgit, Kuner, Ruprecht, Gross, Marie‐Luise, Fink, Bernd, Schirmacher, Peter, Poustka, Annemarie, Berger, Irina |
| author_facet | Finis, Katharina, Sültmann, Holger, Ruschhaupt, Markus, Buness, Andreas, Helmchen, Birgit, Kuner, Ruprecht, Gross, Marie‐Luise, Fink, Bernd, Schirmacher, Peter, Poustka, Annemarie, Berger, Irina, Finis, Katharina, Sültmann, Holger, Ruschhaupt, Markus, Buness, Andreas, Helmchen, Birgit, Kuner, Ruprecht, Gross, Marie‐Luise, Fink, Bernd, Schirmacher, Peter, Poustka, Annemarie, Berger, Irina |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To characterize the gene expression profile and determine potential diagnostic markers and therapeutic targets in pigmented villonodular synovitis (PVNS).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Gene expression patterns in 11 patients with PVNS, 18 patients with rheumatoid arthritis (RA), and 19 patients with osteoarthritis (OA) were investigated using genome‐wide complementary DNA microarrays. Validation of differentially expressed genes was performed by real‐time quantitative polymerase chain reaction and immunohistochemical analysis on tissue arrays (80 patients with PVNS, 51 patients with RA, and 20 patients with OA).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The gene expression profile in PVNS was clearly distinct from those in RA and OA. One hundred forty‐one up‐regulated genes and 47 down‐regulated genes were found in PVNS compared with RA, and 153 up‐regulated genes and 89 down‐regulated genes were found in PVNS compared with OA (fold change ≥1.5;<jats:italic>Q</jats:italic>≤ 0.001). Genes differentially expressed in PVNS were involved in apoptosis regulation, matrix degradation, and inflammation (<jats:italic>ALOX5AP</jats:italic>,<jats:italic>ATP6V1B2</jats:italic>,<jats:italic>CD53</jats:italic>,<jats:italic>CHI3L1</jats:italic>,<jats:italic>CTSL</jats:italic>,<jats:italic>CXCR4</jats:italic>,<jats:italic>HSPA8</jats:italic>,<jats:italic>HSPCA</jats:italic>,<jats:italic>LAPTM5</jats:italic>,<jats:italic>MMP9</jats:italic>,<jats:italic>MOAP1</jats:italic>, and<jats:italic>SPP1</jats:italic>).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The gene expression signature in PVNS is similar to that of activated macrophages and is consistent with the local destructive course of the disease. The gene and protein expression patterns suggest that the ongoing proliferation in PVNS is sustained by apoptosis resistance. This result suggests the possibility of a potential novel therapeutic intervention against PVNS.</jats:p></jats:sec> |
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| imprint | Wiley, 2006 |
| imprint_str_mv | Wiley, 2006 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
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| spelling | Finis, Katharina Sültmann, Holger Ruschhaupt, Markus Buness, Andreas Helmchen, Birgit Kuner, Ruprecht Gross, Marie‐Luise Fink, Bernd Schirmacher, Peter Poustka, Annemarie Berger, Irina 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.21641 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To characterize the gene expression profile and determine potential diagnostic markers and therapeutic targets in pigmented villonodular synovitis (PVNS).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Gene expression patterns in 11 patients with PVNS, 18 patients with rheumatoid arthritis (RA), and 19 patients with osteoarthritis (OA) were investigated using genome‐wide complementary DNA microarrays. Validation of differentially expressed genes was performed by real‐time quantitative polymerase chain reaction and immunohistochemical analysis on tissue arrays (80 patients with PVNS, 51 patients with RA, and 20 patients with OA).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The gene expression profile in PVNS was clearly distinct from those in RA and OA. One hundred forty‐one up‐regulated genes and 47 down‐regulated genes were found in PVNS compared with RA, and 153 up‐regulated genes and 89 down‐regulated genes were found in PVNS compared with OA (fold change ≥1.5;<jats:italic>Q</jats:italic>≤ 0.001). Genes differentially expressed in PVNS were involved in apoptosis regulation, matrix degradation, and inflammation (<jats:italic>ALOX5AP</jats:italic>,<jats:italic>ATP6V1B2</jats:italic>,<jats:italic>CD53</jats:italic>,<jats:italic>CHI3L1</jats:italic>,<jats:italic>CTSL</jats:italic>,<jats:italic>CXCR4</jats:italic>,<jats:italic>HSPA8</jats:italic>,<jats:italic>HSPCA</jats:italic>,<jats:italic>LAPTM5</jats:italic>,<jats:italic>MMP9</jats:italic>,<jats:italic>MOAP1</jats:italic>, and<jats:italic>SPP1</jats:italic>).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The gene expression signature in PVNS is similar to that of activated macrophages and is consistent with the local destructive course of the disease. The gene and protein expression patterns suggest that the ongoing proliferation in PVNS is sustained by apoptosis resistance. This result suggests the possibility of a potential novel therapeutic intervention against PVNS.</jats:p></jats:sec> Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches Arthritis & Rheumatism |
| spellingShingle | Finis, Katharina, Sültmann, Holger, Ruschhaupt, Markus, Buness, Andreas, Helmchen, Birgit, Kuner, Ruprecht, Gross, Marie‐Luise, Fink, Bernd, Schirmacher, Peter, Poustka, Annemarie, Berger, Irina, Arthritis & Rheumatism, Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches, Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| title | Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_full | Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_fullStr | Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_full_unstemmed | Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_short | Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_sort | analysis of pigmented villonodular synovitis with genome‐wide complementary dna microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| title_unstemmed | Analysis of pigmented villonodular synovitis with genome‐wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches |
| topic | Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| url | http://dx.doi.org/10.1002/art.21641 |