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Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy?
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| Zeitschriftentitel: | Ultrasound in Obstetrics & Gynecology |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Ultrasound in Obstetrics & Gynecology, 48, 2016, 4, S. 491-495 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Valensise, H. Farsetti, D. Lo Presti, D. Pisani, I. Tiralongo, G. M. Gagliardi, G. Vasapollo, B. Novelli, G. P. Valensise, H. Farsetti, D. Lo Presti, D. Pisani, I. Tiralongo, G. M. Gagliardi, G. Vasapollo, B. Novelli, G. P. |
|---|---|
| author |
Valensise, H. Farsetti, D. Lo Presti, D. Pisani, I. Tiralongo, G. M. Gagliardi, G. Vasapollo, B. Novelli, G. P. |
| spellingShingle |
Valensise, H. Farsetti, D. Lo Presti, D. Pisani, I. Tiralongo, G. M. Gagliardi, G. Vasapollo, B. Novelli, G. P. Ultrasound in Obstetrics & Gynecology Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? Obstetrics and Gynecology Radiology, Nuclear Medicine and imaging Reproductive Medicine General Medicine Radiological and Ultrasound Technology |
| author_sort |
valensise, h. |
| spelling |
Valensise, H. Farsetti, D. Lo Presti, D. Pisani, I. Tiralongo, G. M. Gagliardi, G. Vasapollo, B. Novelli, G. P. 0960-7692 1469-0705 Wiley Obstetrics and Gynecology Radiology, Nuclear Medicine and imaging Reproductive Medicine General Medicine Radiological and Ultrasound Technology http://dx.doi.org/10.1002/uog.15910 <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate the maternal hemodynamic profile in women with a diagnosis of threatened preterm delivery (<jats:styled-content style="fixed-case">TPD</jats:styled-content>) in order to understand the possible pathophysiologic mechanism leading to an increased lifetime risk for future cardiovascular disease.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients with a diagnosis of <jats:styled-content style="fixed-case">TPD</jats:styled-content> were enrolled and assessed using a non‐invasive method (<jats:styled-content style="fixed-case">USCOM</jats:styled-content><jats:sup>®</jats:sup>) for the determination of hemodynamic parameters. Vaginal and rectal swabs were taken, cervical length, blood inflammatory indices, fetal blood‐vessel Doppler velocimetry were measured and gestational age at the time of delivery and neonatal outcomes were noted.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 68 patients were enrolled and included in the analysis. The population was divided into two groups according to total vascular resistance (<jats:styled-content style="fixed-case">TVR</jats:styled-content>): Group A with a <jats:styled-content style="fixed-case">TVR</jats:styled-content> of ≤ 1000 dynes × s/cm<jats:sup>5</jats:sup> (<jats:italic>n</jats:italic> = 48) and Group B with a <jats:styled-content style="fixed-case">TVR</jats:styled-content> of > 1000 dynes × s/cm<jats:sup>5</jats:sup> (<jats:italic>n</jats:italic> = 20). C‐reactive protein (<jats:styled-content style="fixed-case">CRP</jats:styled-content>) was higher in Group B than in Group A, suggesting a systemic inflammation status. Group B delivered earlier (32 + 4 weeks <jats:italic>vs</jats:italic> 38 + 2 weeks; <jats:italic>P</jats:italic> < 0.01) and neonatal outcome was worse than in Group A. Significantly lower values of cardiac output, stroke volume, peak velocity of flow, velocity time integral, minute distance, stroke volume index, cardiac index, stroke work, cardiac power, inotropy index and potential‐to‐kinetic energy ratio were observed in Group B than in Group A.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Women with a diagnosis of <jats:styled-content style="fixed-case">TPD</jats:styled-content> showing <jats:styled-content style="fixed-case">TVR</jats:styled-content> values of > 1000 dynes × s/cm<jats:sup>5</jats:sup> and elevated levels of <jats:styled-content style="fixed-case">CRP</jats:styled-content> are at high risk of preterm delivery. An impaired maternal cardiovascular adaptation during pregnancy in these patients might suggest a possible higher risk for subsequent future cardiovascular disease. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.</jats:p></jats:sec> Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? Ultrasound in Obstetrics & Gynecology |
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10.1002/uog.15910 |
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Medizin Technik Physik |
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Wiley, 2016 |
| imprint_str_mv |
Wiley, 2016 |
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0960-7692 1469-0705 |
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0960-7692 1469-0705 |
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2016 |
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Wiley |
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Ultrasound in Obstetrics & Gynecology |
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49 |
| title |
Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_unstemmed |
Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_full |
Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_fullStr |
Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_full_unstemmed |
Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_short |
Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_sort |
preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| topic |
Obstetrics and Gynecology Radiology, Nuclear Medicine and imaging Reproductive Medicine General Medicine Radiological and Ultrasound Technology |
| url |
http://dx.doi.org/10.1002/uog.15910 |
| publishDate |
2016 |
| physical |
491-495 |
| description |
<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate the maternal hemodynamic profile in women with a diagnosis of threatened preterm delivery (<jats:styled-content style="fixed-case">TPD</jats:styled-content>) in order to understand the possible pathophysiologic mechanism leading to an increased lifetime risk for future cardiovascular disease.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients with a diagnosis of <jats:styled-content style="fixed-case">TPD</jats:styled-content> were enrolled and assessed using a non‐invasive method (<jats:styled-content style="fixed-case">USCOM</jats:styled-content><jats:sup>®</jats:sup>) for the determination of hemodynamic parameters. Vaginal and rectal swabs were taken, cervical length, blood inflammatory indices, fetal blood‐vessel Doppler velocimetry were measured and gestational age at the time of delivery and neonatal outcomes were noted.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 68 patients were enrolled and included in the analysis. The population was divided into two groups according to total vascular resistance (<jats:styled-content style="fixed-case">TVR</jats:styled-content>): Group A with a <jats:styled-content style="fixed-case">TVR</jats:styled-content> of ≤ 1000 dynes × s/cm<jats:sup>5</jats:sup> (<jats:italic>n</jats:italic> = 48) and Group B with a <jats:styled-content style="fixed-case">TVR</jats:styled-content> of > 1000 dynes × s/cm<jats:sup>5</jats:sup> (<jats:italic>n</jats:italic> = 20). C‐reactive protein (<jats:styled-content style="fixed-case">CRP</jats:styled-content>) was higher in Group B than in Group A, suggesting a systemic inflammation status. Group B delivered earlier (32 + 4 weeks <jats:italic>vs</jats:italic> 38 + 2 weeks; <jats:italic>P</jats:italic> < 0.01) and neonatal outcome was worse than in Group A. Significantly lower values of cardiac output, stroke volume, peak velocity of flow, velocity time integral, minute distance, stroke volume index, cardiac index, stroke work, cardiac power, inotropy index and potential‐to‐kinetic energy ratio were observed in Group B than in Group A.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Women with a diagnosis of <jats:styled-content style="fixed-case">TPD</jats:styled-content> showing <jats:styled-content style="fixed-case">TVR</jats:styled-content> values of > 1000 dynes × s/cm<jats:sup>5</jats:sup> and elevated levels of <jats:styled-content style="fixed-case">CRP</jats:styled-content> are at high risk of preterm delivery. An impaired maternal cardiovascular adaptation during pregnancy in these patients might suggest a possible higher risk for subsequent future cardiovascular disease. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.</jats:p></jats:sec> |
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| author | Valensise, H., Farsetti, D., Lo Presti, D., Pisani, I., Tiralongo, G. M., Gagliardi, G., Vasapollo, B., Novelli, G. P. |
| author_facet | Valensise, H., Farsetti, D., Lo Presti, D., Pisani, I., Tiralongo, G. M., Gagliardi, G., Vasapollo, B., Novelli, G. P., Valensise, H., Farsetti, D., Lo Presti, D., Pisani, I., Tiralongo, G. M., Gagliardi, G., Vasapollo, B., Novelli, G. P. |
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| description | <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate the maternal hemodynamic profile in women with a diagnosis of threatened preterm delivery (<jats:styled-content style="fixed-case">TPD</jats:styled-content>) in order to understand the possible pathophysiologic mechanism leading to an increased lifetime risk for future cardiovascular disease.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients with a diagnosis of <jats:styled-content style="fixed-case">TPD</jats:styled-content> were enrolled and assessed using a non‐invasive method (<jats:styled-content style="fixed-case">USCOM</jats:styled-content><jats:sup>®</jats:sup>) for the determination of hemodynamic parameters. Vaginal and rectal swabs were taken, cervical length, blood inflammatory indices, fetal blood‐vessel Doppler velocimetry were measured and gestational age at the time of delivery and neonatal outcomes were noted.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 68 patients were enrolled and included in the analysis. The population was divided into two groups according to total vascular resistance (<jats:styled-content style="fixed-case">TVR</jats:styled-content>): Group A with a <jats:styled-content style="fixed-case">TVR</jats:styled-content> of ≤ 1000 dynes × s/cm<jats:sup>5</jats:sup> (<jats:italic>n</jats:italic> = 48) and Group B with a <jats:styled-content style="fixed-case">TVR</jats:styled-content> of > 1000 dynes × s/cm<jats:sup>5</jats:sup> (<jats:italic>n</jats:italic> = 20). C‐reactive protein (<jats:styled-content style="fixed-case">CRP</jats:styled-content>) was higher in Group B than in Group A, suggesting a systemic inflammation status. Group B delivered earlier (32 + 4 weeks <jats:italic>vs</jats:italic> 38 + 2 weeks; <jats:italic>P</jats:italic> < 0.01) and neonatal outcome was worse than in Group A. Significantly lower values of cardiac output, stroke volume, peak velocity of flow, velocity time integral, minute distance, stroke volume index, cardiac index, stroke work, cardiac power, inotropy index and potential‐to‐kinetic energy ratio were observed in Group B than in Group A.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Women with a diagnosis of <jats:styled-content style="fixed-case">TPD</jats:styled-content> showing <jats:styled-content style="fixed-case">TVR</jats:styled-content> values of > 1000 dynes × s/cm<jats:sup>5</jats:sup> and elevated levels of <jats:styled-content style="fixed-case">CRP</jats:styled-content> are at high risk of preterm delivery. An impaired maternal cardiovascular adaptation during pregnancy in these patients might suggest a possible higher risk for subsequent future cardiovascular disease. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.</jats:p></jats:sec> |
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| spelling | Valensise, H. Farsetti, D. Lo Presti, D. Pisani, I. Tiralongo, G. M. Gagliardi, G. Vasapollo, B. Novelli, G. P. 0960-7692 1469-0705 Wiley Obstetrics and Gynecology Radiology, Nuclear Medicine and imaging Reproductive Medicine General Medicine Radiological and Ultrasound Technology http://dx.doi.org/10.1002/uog.15910 <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate the maternal hemodynamic profile in women with a diagnosis of threatened preterm delivery (<jats:styled-content style="fixed-case">TPD</jats:styled-content>) in order to understand the possible pathophysiologic mechanism leading to an increased lifetime risk for future cardiovascular disease.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients with a diagnosis of <jats:styled-content style="fixed-case">TPD</jats:styled-content> were enrolled and assessed using a non‐invasive method (<jats:styled-content style="fixed-case">USCOM</jats:styled-content><jats:sup>®</jats:sup>) for the determination of hemodynamic parameters. Vaginal and rectal swabs were taken, cervical length, blood inflammatory indices, fetal blood‐vessel Doppler velocimetry were measured and gestational age at the time of delivery and neonatal outcomes were noted.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 68 patients were enrolled and included in the analysis. The population was divided into two groups according to total vascular resistance (<jats:styled-content style="fixed-case">TVR</jats:styled-content>): Group A with a <jats:styled-content style="fixed-case">TVR</jats:styled-content> of ≤ 1000 dynes × s/cm<jats:sup>5</jats:sup> (<jats:italic>n</jats:italic> = 48) and Group B with a <jats:styled-content style="fixed-case">TVR</jats:styled-content> of > 1000 dynes × s/cm<jats:sup>5</jats:sup> (<jats:italic>n</jats:italic> = 20). C‐reactive protein (<jats:styled-content style="fixed-case">CRP</jats:styled-content>) was higher in Group B than in Group A, suggesting a systemic inflammation status. Group B delivered earlier (32 + 4 weeks <jats:italic>vs</jats:italic> 38 + 2 weeks; <jats:italic>P</jats:italic> < 0.01) and neonatal outcome was worse than in Group A. Significantly lower values of cardiac output, stroke volume, peak velocity of flow, velocity time integral, minute distance, stroke volume index, cardiac index, stroke work, cardiac power, inotropy index and potential‐to‐kinetic energy ratio were observed in Group B than in Group A.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Women with a diagnosis of <jats:styled-content style="fixed-case">TPD</jats:styled-content> showing <jats:styled-content style="fixed-case">TVR</jats:styled-content> values of > 1000 dynes × s/cm<jats:sup>5</jats:sup> and elevated levels of <jats:styled-content style="fixed-case">CRP</jats:styled-content> are at high risk of preterm delivery. An impaired maternal cardiovascular adaptation during pregnancy in these patients might suggest a possible higher risk for subsequent future cardiovascular disease. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.</jats:p></jats:sec> Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? Ultrasound in Obstetrics & Gynecology |
| spellingShingle | Valensise, H., Farsetti, D., Lo Presti, D., Pisani, I., Tiralongo, G. M., Gagliardi, G., Vasapollo, B., Novelli, G. P., Ultrasound in Obstetrics & Gynecology, Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy?, Obstetrics and Gynecology, Radiology, Nuclear Medicine and imaging, Reproductive Medicine, General Medicine, Radiological and Ultrasound Technology |
| title | Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_full | Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_fullStr | Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_full_unstemmed | Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_short | Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_sort | preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| title_unstemmed | Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy? |
| topic | Obstetrics and Gynecology, Radiology, Nuclear Medicine and imaging, Reproductive Medicine, General Medicine, Radiological and Ultrasound Technology |
| url | http://dx.doi.org/10.1002/uog.15910 |