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Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology
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| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , |
| In: | FEBS Letters, 592, 2018, 12, S. 2140-2152 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Fukuto, Jon M. Ignarro, Louis J. Nagy, Peter Wink, David A. Kevil, Christopher G. Feelisch, Martin Cortese‐Krott, Miriam M. Bianco, Christopher L. Kumagai, Yoshito Hobbs, Adrian J. Lin, Joseph Ida, Tomoaki Akaike, Takaaki Fukuto, Jon M. Ignarro, Louis J. Nagy, Peter Wink, David A. Kevil, Christopher G. Feelisch, Martin Cortese‐Krott, Miriam M. Bianco, Christopher L. Kumagai, Yoshito Hobbs, Adrian J. Lin, Joseph Ida, Tomoaki Akaike, Takaaki |
|---|---|
| author |
Fukuto, Jon M. Ignarro, Louis J. Nagy, Peter Wink, David A. Kevil, Christopher G. Feelisch, Martin Cortese‐Krott, Miriam M. Bianco, Christopher L. Kumagai, Yoshito Hobbs, Adrian J. Lin, Joseph Ida, Tomoaki Akaike, Takaaki |
| spellingShingle |
Fukuto, Jon M. Ignarro, Louis J. Nagy, Peter Wink, David A. Kevil, Christopher G. Feelisch, Martin Cortese‐Krott, Miriam M. Bianco, Christopher L. Kumagai, Yoshito Hobbs, Adrian J. Lin, Joseph Ida, Tomoaki Akaike, Takaaki FEBS Letters Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
fukuto, jon m. |
| spelling |
Fukuto, Jon M. Ignarro, Louis J. Nagy, Peter Wink, David A. Kevil, Christopher G. Feelisch, Martin Cortese‐Krott, Miriam M. Bianco, Christopher L. Kumagai, Yoshito Hobbs, Adrian J. Lin, Joseph Ida, Tomoaki Akaike, Takaaki 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1002/1873-3468.13090 <jats:p>The chemical biology of thiols (RSH, e.g., cysteine and cysteine‐containing proteins/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure/folding, redox signaling, metal ligation, cellular protection, and enzymology. While many of the studies on thiol/sulfur biochemistry have focused on thiols, relatively ignored have been hydropersulfides (RSSH) and higher order polysulfur species (RSS<jats:sub>n</jats:sub>H, RSS<jats:sub>n</jats:sub>R, <jats:italic>n</jats:italic> > 1). Recent and provocative work has alluded to the prevalence and likely physiological importance of RSSH and related RSS<jats:sub>n</jats:sub>H. RSSH of cysteine (Cys‐SSH) has been found to be prevalent in mammalian systems along with Cys‐SSH‐containing proteins. The RSSH functionality has not been examined to the extent of other biologically relevant sulfur derivatives (e.g., sulfenic acids, disulfides, etc.), whose roles in cell signaling are strongly indicated. The recent finding of Cys‐SSH biosynthesis and translational incorporation into proteins is an unequivocal indication of its fundamental importance and necessitates a more profound look into the physiology of RSSH. In this Review, we discuss the currently reported chemical biology of RSSH (and related species) as a prelude to discussing their possible physiological roles.</jats:p> Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology FEBS Letters |
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| title |
Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_unstemmed |
Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_full |
Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_fullStr |
Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_full_unstemmed |
Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_short |
Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_sort |
biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| topic |
Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| url |
http://dx.doi.org/10.1002/1873-3468.13090 |
| publishDate |
2018 |
| physical |
2140-2152 |
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<jats:p>The chemical biology of thiols (RSH, e.g., cysteine and cysteine‐containing proteins/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure/folding, redox signaling, metal ligation, cellular protection, and enzymology. While many of the studies on thiol/sulfur biochemistry have focused on thiols, relatively ignored have been hydropersulfides (RSSH) and higher order polysulfur species (RSS<jats:sub>n</jats:sub>H, RSS<jats:sub>n</jats:sub>R, <jats:italic>n</jats:italic> > 1). Recent and provocative work has alluded to the prevalence and likely physiological importance of RSSH and related RSS<jats:sub>n</jats:sub>H. RSSH of cysteine (Cys‐SSH) has been found to be prevalent in mammalian systems along with Cys‐SSH‐containing proteins. The RSSH functionality has not been examined to the extent of other biologically relevant sulfur derivatives (e.g., sulfenic acids, disulfides, etc.), whose roles in cell signaling are strongly indicated. The recent finding of Cys‐SSH biosynthesis and translational incorporation into proteins is an unequivocal indication of its fundamental importance and necessitates a more profound look into the physiology of RSSH. In this Review, we discuss the currently reported chemical biology of RSSH (and related species) as a prelude to discussing their possible physiological roles.</jats:p> |
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| author | Fukuto, Jon M., Ignarro, Louis J., Nagy, Peter, Wink, David A., Kevil, Christopher G., Feelisch, Martin, Cortese‐Krott, Miriam M., Bianco, Christopher L., Kumagai, Yoshito, Hobbs, Adrian J., Lin, Joseph, Ida, Tomoaki, Akaike, Takaaki |
| author_facet | Fukuto, Jon M., Ignarro, Louis J., Nagy, Peter, Wink, David A., Kevil, Christopher G., Feelisch, Martin, Cortese‐Krott, Miriam M., Bianco, Christopher L., Kumagai, Yoshito, Hobbs, Adrian J., Lin, Joseph, Ida, Tomoaki, Akaike, Takaaki, Fukuto, Jon M., Ignarro, Louis J., Nagy, Peter, Wink, David A., Kevil, Christopher G., Feelisch, Martin, Cortese‐Krott, Miriam M., Bianco, Christopher L., Kumagai, Yoshito, Hobbs, Adrian J., Lin, Joseph, Ida, Tomoaki, Akaike, Takaaki |
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| description | <jats:p>The chemical biology of thiols (RSH, e.g., cysteine and cysteine‐containing proteins/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure/folding, redox signaling, metal ligation, cellular protection, and enzymology. While many of the studies on thiol/sulfur biochemistry have focused on thiols, relatively ignored have been hydropersulfides (RSSH) and higher order polysulfur species (RSS<jats:sub>n</jats:sub>H, RSS<jats:sub>n</jats:sub>R, <jats:italic>n</jats:italic> > 1). Recent and provocative work has alluded to the prevalence and likely physiological importance of RSSH and related RSS<jats:sub>n</jats:sub>H. RSSH of cysteine (Cys‐SSH) has been found to be prevalent in mammalian systems along with Cys‐SSH‐containing proteins. The RSSH functionality has not been examined to the extent of other biologically relevant sulfur derivatives (e.g., sulfenic acids, disulfides, etc.), whose roles in cell signaling are strongly indicated. The recent finding of Cys‐SSH biosynthesis and translational incorporation into proteins is an unequivocal indication of its fundamental importance and necessitates a more profound look into the physiology of RSSH. In this Review, we discuss the currently reported chemical biology of RSSH (and related species) as a prelude to discussing their possible physiological roles.</jats:p> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229 |
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| spelling | Fukuto, Jon M. Ignarro, Louis J. Nagy, Peter Wink, David A. Kevil, Christopher G. Feelisch, Martin Cortese‐Krott, Miriam M. Bianco, Christopher L. Kumagai, Yoshito Hobbs, Adrian J. Lin, Joseph Ida, Tomoaki Akaike, Takaaki 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1002/1873-3468.13090 <jats:p>The chemical biology of thiols (RSH, e.g., cysteine and cysteine‐containing proteins/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure/folding, redox signaling, metal ligation, cellular protection, and enzymology. While many of the studies on thiol/sulfur biochemistry have focused on thiols, relatively ignored have been hydropersulfides (RSSH) and higher order polysulfur species (RSS<jats:sub>n</jats:sub>H, RSS<jats:sub>n</jats:sub>R, <jats:italic>n</jats:italic> > 1). Recent and provocative work has alluded to the prevalence and likely physiological importance of RSSH and related RSS<jats:sub>n</jats:sub>H. RSSH of cysteine (Cys‐SSH) has been found to be prevalent in mammalian systems along with Cys‐SSH‐containing proteins. The RSSH functionality has not been examined to the extent of other biologically relevant sulfur derivatives (e.g., sulfenic acids, disulfides, etc.), whose roles in cell signaling are strongly indicated. The recent finding of Cys‐SSH biosynthesis and translational incorporation into proteins is an unequivocal indication of its fundamental importance and necessitates a more profound look into the physiology of RSSH. In this Review, we discuss the currently reported chemical biology of RSSH (and related species) as a prelude to discussing their possible physiological roles.</jats:p> Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology FEBS Letters |
| spellingShingle | Fukuto, Jon M., Ignarro, Louis J., Nagy, Peter, Wink, David A., Kevil, Christopher G., Feelisch, Martin, Cortese‐Krott, Miriam M., Bianco, Christopher L., Kumagai, Yoshito, Hobbs, Adrian J., Lin, Joseph, Ida, Tomoaki, Akaike, Takaaki, FEBS Letters, Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_full | Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_fullStr | Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_full_unstemmed | Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_short | Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_sort | biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| title_unstemmed | Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1002/1873-3468.13090 |