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Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls
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| Zeitschriftentitel: | Journal of Pediatric Gastroenterology and Nutrition |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Journal of Pediatric Gastroenterology and Nutrition, 61, 2015, 3, S. 323-329 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Varni, James W. Shulman, Robert J. Self, Mariella M. Nurko, Samuel Saps, Miguel Saeed, Shehzad A. Bendo, Cristiane B. Patel, Ashish S. Dark, Chelsea Vaughan Zacur, George M. Pohl, John F. Varni, James W. Shulman, Robert J. Self, Mariella M. Nurko, Samuel Saps, Miguel Saeed, Shehzad A. Bendo, Cristiane B. Patel, Ashish S. Dark, Chelsea Vaughan Zacur, George M. Pohl, John F. |
|---|---|
| author |
Varni, James W. Shulman, Robert J. Self, Mariella M. Nurko, Samuel Saps, Miguel Saeed, Shehzad A. Bendo, Cristiane B. Patel, Ashish S. Dark, Chelsea Vaughan Zacur, George M. Pohl, John F. |
| spellingShingle |
Varni, James W. Shulman, Robert J. Self, Mariella M. Nurko, Samuel Saps, Miguel Saeed, Shehzad A. Bendo, Cristiane B. Patel, Ashish S. Dark, Chelsea Vaughan Zacur, George M. Pohl, John F. Journal of Pediatric Gastroenterology and Nutrition Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls Gastroenterology Pediatrics, Perinatology and Child Health |
| author_sort |
varni, james w. |
| spelling |
Varni, James W. Shulman, Robert J. Self, Mariella M. Nurko, Samuel Saps, Miguel Saeed, Shehzad A. Bendo, Cristiane B. Patel, Ashish S. Dark, Chelsea Vaughan Zacur, George M. Pohl, John F. 0277-2116 1536-4801 Wiley Gastroenterology Pediatrics, Perinatology and Child Health http://dx.doi.org/10.1097/mpg.0000000000000795 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives:</jats:title><jats:p>Patient‐reported outcome (PRO) measures of gastrointestinal symptoms are recommended to determine treatment effects for irritable bowel syndrome (IBS) and functional abdominal pain (FAP). Study objectives were to compare the symptom profiles of pediatric patients with IBS or FAP with healthy controls and with each other using the PedsQL Gastrointestinal Symptoms and Gastrointestinal Worry Scales, and to establish clinical interpretability of PRO scale scores through identification of minimal important difference (MID) scores.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Gastrointestinal Symptoms and Worry Scales were completed in a 9‐site study by 154 pediatric patients and 161 parents (162 families; IBS n = 46, FAP n = 119). Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were administered along with Gastrointestinal Worry Scales. A matched sample of 447 families with healthy children completed the scales.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Gastrointestinal Symptoms and Worry Scales distinguished between patients with IBS or FAP compared with healthy controls (<jats:italic>P</jats:italic> < 0.001), with larger effect sizes (>1.50) for symptoms indicative of IBS or FAP, demonstrating a broad multidimensional gastrointestinal symptom profile and clinical interpretability with MID scores for individual PRO scales. Patients with IBS manifested more symptoms of constipation, gas and bloating, and diarrhea than patients with FAP.</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>Patients with IBS or FAP manifested a broad gastrointestinal symptom profile compared with healthy controls with large differences, indicating the critical need for more effective interventions to bring patient functioning within the range of healthy functioning.</jats:p></jats:sec> Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls Journal of Pediatric Gastroenterology and Nutrition |
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| title |
Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_unstemmed |
Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_full |
Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_fullStr |
Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_full_unstemmed |
Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_short |
Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_sort |
symptom profiles in patients with irritable bowel syndrome or functional abdominal pain compared with healthy controls |
| topic |
Gastroenterology Pediatrics, Perinatology and Child Health |
| url |
http://dx.doi.org/10.1097/mpg.0000000000000795 |
| publishDate |
2015 |
| physical |
323-329 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives:</jats:title><jats:p>Patient‐reported outcome (PRO) measures of gastrointestinal symptoms are recommended to determine treatment effects for irritable bowel syndrome (IBS) and functional abdominal pain (FAP). Study objectives were to compare the symptom profiles of pediatric patients with IBS or FAP with healthy controls and with each other using the PedsQL Gastrointestinal Symptoms and Gastrointestinal Worry Scales, and to establish clinical interpretability of PRO scale scores through identification of minimal important difference (MID) scores.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Gastrointestinal Symptoms and Worry Scales were completed in a 9‐site study by 154 pediatric patients and 161 parents (162 families; IBS n = 46, FAP n = 119). Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were administered along with Gastrointestinal Worry Scales. A matched sample of 447 families with healthy children completed the scales.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Gastrointestinal Symptoms and Worry Scales distinguished between patients with IBS or FAP compared with healthy controls (<jats:italic>P</jats:italic> < 0.001), with larger effect sizes (>1.50) for symptoms indicative of IBS or FAP, demonstrating a broad multidimensional gastrointestinal symptom profile and clinical interpretability with MID scores for individual PRO scales. Patients with IBS manifested more symptoms of constipation, gas and bloating, and diarrhea than patients with FAP.</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>Patients with IBS or FAP manifested a broad gastrointestinal symptom profile compared with healthy controls with large differences, indicating the critical need for more effective interventions to bring patient functioning within the range of healthy functioning.</jats:p></jats:sec> |
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| author | Varni, James W., Shulman, Robert J., Self, Mariella M., Nurko, Samuel, Saps, Miguel, Saeed, Shehzad A., Bendo, Cristiane B., Patel, Ashish S., Dark, Chelsea Vaughan, Zacur, George M., Pohl, John F. |
| author_facet | Varni, James W., Shulman, Robert J., Self, Mariella M., Nurko, Samuel, Saps, Miguel, Saeed, Shehzad A., Bendo, Cristiane B., Patel, Ashish S., Dark, Chelsea Vaughan, Zacur, George M., Pohl, John F., Varni, James W., Shulman, Robert J., Self, Mariella M., Nurko, Samuel, Saps, Miguel, Saeed, Shehzad A., Bendo, Cristiane B., Patel, Ashish S., Dark, Chelsea Vaughan, Zacur, George M., Pohl, John F. |
| author_sort | varni, james w. |
| container_issue | 3 |
| container_start_page | 323 |
| container_title | Journal of Pediatric Gastroenterology and Nutrition |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives:</jats:title><jats:p>Patient‐reported outcome (PRO) measures of gastrointestinal symptoms are recommended to determine treatment effects for irritable bowel syndrome (IBS) and functional abdominal pain (FAP). Study objectives were to compare the symptom profiles of pediatric patients with IBS or FAP with healthy controls and with each other using the PedsQL Gastrointestinal Symptoms and Gastrointestinal Worry Scales, and to establish clinical interpretability of PRO scale scores through identification of minimal important difference (MID) scores.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Gastrointestinal Symptoms and Worry Scales were completed in a 9‐site study by 154 pediatric patients and 161 parents (162 families; IBS n = 46, FAP n = 119). Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were administered along with Gastrointestinal Worry Scales. A matched sample of 447 families with healthy children completed the scales.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Gastrointestinal Symptoms and Worry Scales distinguished between patients with IBS or FAP compared with healthy controls (<jats:italic>P</jats:italic> < 0.001), with larger effect sizes (>1.50) for symptoms indicative of IBS or FAP, demonstrating a broad multidimensional gastrointestinal symptom profile and clinical interpretability with MID scores for individual PRO scales. Patients with IBS manifested more symptoms of constipation, gas and bloating, and diarrhea than patients with FAP.</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>Patients with IBS or FAP manifested a broad gastrointestinal symptom profile compared with healthy controls with large differences, indicating the critical need for more effective interventions to bring patient functioning within the range of healthy functioning.</jats:p></jats:sec> |
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| imprint | Wiley, 2015 |
| imprint_str_mv | Wiley, 2015 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0277-2116, 1536-4801 |
| issn_str_mv | 0277-2116, 1536-4801 |
| language | English |
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| physical | 323-329 |
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| spelling | Varni, James W. Shulman, Robert J. Self, Mariella M. Nurko, Samuel Saps, Miguel Saeed, Shehzad A. Bendo, Cristiane B. Patel, Ashish S. Dark, Chelsea Vaughan Zacur, George M. Pohl, John F. 0277-2116 1536-4801 Wiley Gastroenterology Pediatrics, Perinatology and Child Health http://dx.doi.org/10.1097/mpg.0000000000000795 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives:</jats:title><jats:p>Patient‐reported outcome (PRO) measures of gastrointestinal symptoms are recommended to determine treatment effects for irritable bowel syndrome (IBS) and functional abdominal pain (FAP). Study objectives were to compare the symptom profiles of pediatric patients with IBS or FAP with healthy controls and with each other using the PedsQL Gastrointestinal Symptoms and Gastrointestinal Worry Scales, and to establish clinical interpretability of PRO scale scores through identification of minimal important difference (MID) scores.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Gastrointestinal Symptoms and Worry Scales were completed in a 9‐site study by 154 pediatric patients and 161 parents (162 families; IBS n = 46, FAP n = 119). Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were administered along with Gastrointestinal Worry Scales. A matched sample of 447 families with healthy children completed the scales.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Gastrointestinal Symptoms and Worry Scales distinguished between patients with IBS or FAP compared with healthy controls (<jats:italic>P</jats:italic> < 0.001), with larger effect sizes (>1.50) for symptoms indicative of IBS or FAP, demonstrating a broad multidimensional gastrointestinal symptom profile and clinical interpretability with MID scores for individual PRO scales. Patients with IBS manifested more symptoms of constipation, gas and bloating, and diarrhea than patients with FAP.</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>Patients with IBS or FAP manifested a broad gastrointestinal symptom profile compared with healthy controls with large differences, indicating the critical need for more effective interventions to bring patient functioning within the range of healthy functioning.</jats:p></jats:sec> Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls Journal of Pediatric Gastroenterology and Nutrition |
| spellingShingle | Varni, James W., Shulman, Robert J., Self, Mariella M., Nurko, Samuel, Saps, Miguel, Saeed, Shehzad A., Bendo, Cristiane B., Patel, Ashish S., Dark, Chelsea Vaughan, Zacur, George M., Pohl, John F., Journal of Pediatric Gastroenterology and Nutrition, Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls, Gastroenterology, Pediatrics, Perinatology and Child Health |
| title | Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_full | Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_fullStr | Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_full_unstemmed | Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_short | Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| title_sort | symptom profiles in patients with irritable bowel syndrome or functional abdominal pain compared with healthy controls |
| title_unstemmed | Symptom Profiles in Patients With Irritable Bowel Syndrome or Functional Abdominal Pain Compared With Healthy Controls |
| topic | Gastroenterology, Pediatrics, Perinatology and Child Health |
| url | http://dx.doi.org/10.1097/mpg.0000000000000795 |