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Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2
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| Zeitschriftentitel: | Journal of Antimicrobial Chemotherapy |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Journal of Antimicrobial Chemotherapy, 72, 2017, 12, S. 3283-3287 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Arana, David M Ortega, Adriana González-Barberá, Eva Lara, Noelia Bautista, Verónica Gómez-Ruíz, Dolores Sáez, David Fernández-Romero, Sara Aracil, Belén Pérez-Vázquez, María Campos, José Oteo, Jesús Arana, David M Ortega, Adriana González-Barberá, Eva Lara, Noelia Bautista, Verónica Gómez-Ruíz, Dolores Sáez, David Fernández-Romero, Sara Aracil, Belén Pérez-Vázquez, María Campos, José Oteo, Jesús |
|---|---|
| author |
Arana, David M Ortega, Adriana González-Barberá, Eva Lara, Noelia Bautista, Verónica Gómez-Ruíz, Dolores Sáez, David Fernández-Romero, Sara Aracil, Belén Pérez-Vázquez, María Campos, José Oteo, Jesús |
| spellingShingle |
Arana, David M Ortega, Adriana González-Barberá, Eva Lara, Noelia Bautista, Verónica Gómez-Ruíz, Dolores Sáez, David Fernández-Romero, Sara Aracil, Belén Pérez-Vázquez, María Campos, José Oteo, Jesús Journal of Antimicrobial Chemotherapy Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 Infectious Diseases Pharmacology (medical) Pharmacology Microbiology (medical) |
| author_sort |
arana, david m |
| spelling |
Arana, David M Ortega, Adriana González-Barberá, Eva Lara, Noelia Bautista, Verónica Gómez-Ruíz, Dolores Sáez, David Fernández-Romero, Sara Aracil, Belén Pérez-Vázquez, María Campos, José Oteo, Jesús 0305-7453 1460-2091 Oxford University Press (OUP) Infectious Diseases Pharmacology (medical) Pharmacology Microbiology (medical) http://dx.doi.org/10.1093/jac/dkx325 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013–15).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Of the 119 isolates, 63 (52.9%) produced carbapenemases, of which 37 (58.7%) produced VIM-1, 20 (31.7%) produced OXA-48, 12 (19%) produced KPC-2, 2 (3.2%) produced NDM-1 and 1 (1.6%) produced VIM-2; 9 C. freundii isolates co-produced VIM-1 plus OXA-48. Fourteen isolates (22.2%) also carried ESBLs: 8 CTX-M-9 plus SHV-12, 2 CTX-M-9, 2 SHV-12 and 2 CTX-M-15. Fifty-seven isolates (90.5%) were C. freundii, 4 (6.3%) were Citrobacter koseri, 1 (1.6%) was Citrobacter amalonaticus and 1 (1.6%) was Citrobacter braakii. By EUCAST breakpoints, eight (12.7%) of the CP isolates were susceptible to the four carbapenems tested. In the 53 CP C. freundii analysed by PFGE, a total of 44 different band patterns were observed. Four PFGE clusters were identified: cluster 1 included eight isolates co-producing VIM-1 and OXA-48; blaVIM-1 was carried in a class 1 integron (intI–blaVIM-1–aacA4–dfrB1–aadA1–catB2–qacEΔ1/sul1) and blaOXA-48 was carried in a Tn1999.2 transposon.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>We observed the clonal and polyclonal spread of CP Citrobacter spp. across several Spanish geographical areas. Four species of Citrobacter spp. produced up to five carbapenemase types, including co-production of VIM-1 plus OXA-48. Some CP Citrobacter spp. isolates were susceptible to the four carbapenems tested, a finding with potential clinical implications.</jats:p> </jats:sec> Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 Journal of Antimicrobial Chemotherapy |
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Oxford University Press (OUP), 2017 |
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Oxford University Press (OUP), 2017 |
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Journal of Antimicrobial Chemotherapy |
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49 |
| title |
Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_unstemmed |
Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_full |
Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_fullStr |
Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_full_unstemmed |
Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_short |
Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_sort |
carbapenem-resistant citrobacter spp. isolated in spain from 2013 to 2015 produced a variety of carbapenemases including vim-1, oxa-48, kpc-2, ndm-1 and vim-2 |
| topic |
Infectious Diseases Pharmacology (medical) Pharmacology Microbiology (medical) |
| url |
http://dx.doi.org/10.1093/jac/dkx325 |
| publishDate |
2017 |
| physical |
3283-3287 |
| description |
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Objectives</jats:title>
<jats:p>There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013–15).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>Of the 119 isolates, 63 (52.9%) produced carbapenemases, of which 37 (58.7%) produced VIM-1, 20 (31.7%) produced OXA-48, 12 (19%) produced KPC-2, 2 (3.2%) produced NDM-1 and 1 (1.6%) produced VIM-2; 9 C. freundii isolates co-produced VIM-1 plus OXA-48. Fourteen isolates (22.2%) also carried ESBLs: 8 CTX-M-9 plus SHV-12, 2 CTX-M-9, 2 SHV-12 and 2 CTX-M-15. Fifty-seven isolates (90.5%) were C. freundii, 4 (6.3%) were Citrobacter koseri, 1 (1.6%) was Citrobacter amalonaticus and 1 (1.6%) was Citrobacter braakii. By EUCAST breakpoints, eight (12.7%) of the CP isolates were susceptible to the four carbapenems tested. In the 53 CP C. freundii analysed by PFGE, a total of 44 different band patterns were observed. Four PFGE clusters were identified: cluster 1 included eight isolates co-producing VIM-1 and OXA-48; blaVIM-1 was carried in a class 1 integron (intI–blaVIM-1–aacA4–dfrB1–aadA1–catB2–qacEΔ1/sul1) and blaOXA-48 was carried in a Tn1999.2 transposon.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions</jats:title>
<jats:p>We observed the clonal and polyclonal spread of CP Citrobacter spp. across several Spanish geographical areas. Four species of Citrobacter spp. produced up to five carbapenemase types, including co-production of VIM-1 plus OXA-48. Some CP Citrobacter spp. isolates were susceptible to the four carbapenems tested, a finding with potential clinical implications.</jats:p>
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| author | Arana, David M, Ortega, Adriana, González-Barberá, Eva, Lara, Noelia, Bautista, Verónica, Gómez-Ruíz, Dolores, Sáez, David, Fernández-Romero, Sara, Aracil, Belén, Pérez-Vázquez, María, Campos, José, Oteo, Jesús |
| author_facet | Arana, David M, Ortega, Adriana, González-Barberá, Eva, Lara, Noelia, Bautista, Verónica, Gómez-Ruíz, Dolores, Sáez, David, Fernández-Romero, Sara, Aracil, Belén, Pérez-Vázquez, María, Campos, José, Oteo, Jesús, Arana, David M, Ortega, Adriana, González-Barberá, Eva, Lara, Noelia, Bautista, Verónica, Gómez-Ruíz, Dolores, Sáez, David, Fernández-Romero, Sara, Aracil, Belén, Pérez-Vázquez, María, Campos, José, Oteo, Jesús |
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| description | <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013–15).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Of the 119 isolates, 63 (52.9%) produced carbapenemases, of which 37 (58.7%) produced VIM-1, 20 (31.7%) produced OXA-48, 12 (19%) produced KPC-2, 2 (3.2%) produced NDM-1 and 1 (1.6%) produced VIM-2; 9 C. freundii isolates co-produced VIM-1 plus OXA-48. Fourteen isolates (22.2%) also carried ESBLs: 8 CTX-M-9 plus SHV-12, 2 CTX-M-9, 2 SHV-12 and 2 CTX-M-15. Fifty-seven isolates (90.5%) were C. freundii, 4 (6.3%) were Citrobacter koseri, 1 (1.6%) was Citrobacter amalonaticus and 1 (1.6%) was Citrobacter braakii. By EUCAST breakpoints, eight (12.7%) of the CP isolates were susceptible to the four carbapenems tested. In the 53 CP C. freundii analysed by PFGE, a total of 44 different band patterns were observed. Four PFGE clusters were identified: cluster 1 included eight isolates co-producing VIM-1 and OXA-48; blaVIM-1 was carried in a class 1 integron (intI–blaVIM-1–aacA4–dfrB1–aadA1–catB2–qacEΔ1/sul1) and blaOXA-48 was carried in a Tn1999.2 transposon.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>We observed the clonal and polyclonal spread of CP Citrobacter spp. across several Spanish geographical areas. Four species of Citrobacter spp. produced up to five carbapenemase types, including co-production of VIM-1 plus OXA-48. Some CP Citrobacter spp. isolates were susceptible to the four carbapenems tested, a finding with potential clinical implications.</jats:p> </jats:sec> |
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| spelling | Arana, David M Ortega, Adriana González-Barberá, Eva Lara, Noelia Bautista, Verónica Gómez-Ruíz, Dolores Sáez, David Fernández-Romero, Sara Aracil, Belén Pérez-Vázquez, María Campos, José Oteo, Jesús 0305-7453 1460-2091 Oxford University Press (OUP) Infectious Diseases Pharmacology (medical) Pharmacology Microbiology (medical) http://dx.doi.org/10.1093/jac/dkx325 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013–15).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Of the 119 isolates, 63 (52.9%) produced carbapenemases, of which 37 (58.7%) produced VIM-1, 20 (31.7%) produced OXA-48, 12 (19%) produced KPC-2, 2 (3.2%) produced NDM-1 and 1 (1.6%) produced VIM-2; 9 C. freundii isolates co-produced VIM-1 plus OXA-48. Fourteen isolates (22.2%) also carried ESBLs: 8 CTX-M-9 plus SHV-12, 2 CTX-M-9, 2 SHV-12 and 2 CTX-M-15. Fifty-seven isolates (90.5%) were C. freundii, 4 (6.3%) were Citrobacter koseri, 1 (1.6%) was Citrobacter amalonaticus and 1 (1.6%) was Citrobacter braakii. By EUCAST breakpoints, eight (12.7%) of the CP isolates were susceptible to the four carbapenems tested. In the 53 CP C. freundii analysed by PFGE, a total of 44 different band patterns were observed. Four PFGE clusters were identified: cluster 1 included eight isolates co-producing VIM-1 and OXA-48; blaVIM-1 was carried in a class 1 integron (intI–blaVIM-1–aacA4–dfrB1–aadA1–catB2–qacEΔ1/sul1) and blaOXA-48 was carried in a Tn1999.2 transposon.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>We observed the clonal and polyclonal spread of CP Citrobacter spp. across several Spanish geographical areas. Four species of Citrobacter spp. produced up to five carbapenemase types, including co-production of VIM-1 plus OXA-48. Some CP Citrobacter spp. isolates were susceptible to the four carbapenems tested, a finding with potential clinical implications.</jats:p> </jats:sec> Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 Journal of Antimicrobial Chemotherapy |
| spellingShingle | Arana, David M, Ortega, Adriana, González-Barberá, Eva, Lara, Noelia, Bautista, Verónica, Gómez-Ruíz, Dolores, Sáez, David, Fernández-Romero, Sara, Aracil, Belén, Pérez-Vázquez, María, Campos, José, Oteo, Jesús, Journal of Antimicrobial Chemotherapy, Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2, Infectious Diseases, Pharmacology (medical), Pharmacology, Microbiology (medical) |
| title | Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_full | Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_fullStr | Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_full_unstemmed | Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_short | Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| title_sort | carbapenem-resistant citrobacter spp. isolated in spain from 2013 to 2015 produced a variety of carbapenemases including vim-1, oxa-48, kpc-2, ndm-1 and vim-2 |
| title_unstemmed | Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2 |
| topic | Infectious Diseases, Pharmacology (medical), Pharmacology, Microbiology (medical) |
| url | http://dx.doi.org/10.1093/jac/dkx325 |