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Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction

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Zeitschriftentitel: European Journal of Heart Failure
Personen und Körperschaften: Carluccio, Erberto, Biagioli, Paolo, Alunni, Gianfranco, Murrone, Adriano, Leonelli, Valeria, Pantano, Paola, Biscottini, Emilia, Paulus, Walter J., Ambrosio, Giuseppe
In: European Journal of Heart Failure, 13, 2011, 3, S. 292-302
Format: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Cardiology and Cardiovascular Medicine
author_facet Carluccio, Erberto
Biagioli, Paolo
Alunni, Gianfranco
Murrone, Adriano
Leonelli, Valeria
Pantano, Paola
Biscottini, Emilia
Paulus, Walter J.
Ambrosio, Giuseppe
Carluccio, Erberto
Biagioli, Paolo
Alunni, Gianfranco
Murrone, Adriano
Leonelli, Valeria
Pantano, Paola
Biscottini, Emilia
Paulus, Walter J.
Ambrosio, Giuseppe
author Carluccio, Erberto
Biagioli, Paolo
Alunni, Gianfranco
Murrone, Adriano
Leonelli, Valeria
Pantano, Paola
Biscottini, Emilia
Paulus, Walter J.
Ambrosio, Giuseppe
spellingShingle Carluccio, Erberto
Biagioli, Paolo
Alunni, Gianfranco
Murrone, Adriano
Leonelli, Valeria
Pantano, Paola
Biscottini, Emilia
Paulus, Walter J.
Ambrosio, Giuseppe
European Journal of Heart Failure
Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
Cardiology and Cardiovascular Medicine
author_sort carluccio, erberto
spelling Carluccio, Erberto Biagioli, Paolo Alunni, Gianfranco Murrone, Adriano Leonelli, Valeria Pantano, Paola Biscottini, Emilia Paulus, Walter J. Ambrosio, Giuseppe 1388-9842 1879-0844 Wiley Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1093/eurjhf/hfq203 <jats:sec><jats:title>Aims</jats:title><jats:p>Tissue Doppler imaging (TDI) systolic velocities have been used to detect impaired systolic function in patients with heart failure and normal ejection fraction (HFnEF). However, many patients do not show alterations by this technique, and furthermore, myocardial systolic velocities can be affected by tethering, translation, and loading conditions. Thus, uncertainties remain about the detection of abnormal systolic function in HFnEF patients. The aim of this study was, therefore, to compare systolic velocities vs. TDI‐derived deformation indices for detection of possible abnormalities of systolic function in HFnEF patients, taking into account loading conditions.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>We studied 40 patients with systolic heart failure (SHF: EF ≤40%), 47 HFnEF patients, and 50 controls (C). Systolic velocities of the mitral annulus (pulsed‐wave TDI) were measured at four sites and averaged; concomitantly, peak negative TDI‐derived strain and strain rate of the four walls were measured in apical, four‐, and two‐chamber views. Ejection fraction was 65 ± 6% in C, 62 ± 7% in HFnEF, and 29 ± 7% in SHF (<jats:italic>P</jats:italic>&lt; 0.001 vs. both). In HFnEF patients, systolic velocities and peak negative global longitudinal strain rate and strain were higher than in SHF (<jats:italic>P</jats:italic>&lt; 0.0001 for all), but lower than in C (<jats:italic>P</jats:italic>&lt; 0.0001 for all). After controlling for age, left ventricular mass index, end‐diastolic volume index, and circumferential end‐systolic stress, differences between groups remained significant for deformation indices but not for TDI velocities. By velocity/strain–stress relationship analysis, peak global longitudinal strain was more sensitive than peak systolic motion in detecting systolic dysfunction in HFnEF patients (64 vs. 40%, <jats:italic>P</jats:italic>&lt; 0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In patients with HFnEF, TDI‐derived deformation indices may more accurately detect abnormal systolic function than myocardial velocities.</jats:p></jats:sec> Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction European Journal of Heart Failure
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title Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_unstemmed Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_full Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_fullStr Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_full_unstemmed Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_short Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_sort advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
topic Cardiology and Cardiovascular Medicine
url http://dx.doi.org/10.1093/eurjhf/hfq203
publishDate 2011
physical 292-302
description <jats:sec><jats:title>Aims</jats:title><jats:p>Tissue Doppler imaging (TDI) systolic velocities have been used to detect impaired systolic function in patients with heart failure and normal ejection fraction (HFnEF). However, many patients do not show alterations by this technique, and furthermore, myocardial systolic velocities can be affected by tethering, translation, and loading conditions. Thus, uncertainties remain about the detection of abnormal systolic function in HFnEF patients. The aim of this study was, therefore, to compare systolic velocities vs. TDI‐derived deformation indices for detection of possible abnormalities of systolic function in HFnEF patients, taking into account loading conditions.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>We studied 40 patients with systolic heart failure (SHF: EF ≤40%), 47 HFnEF patients, and 50 controls (C). Systolic velocities of the mitral annulus (pulsed‐wave TDI) were measured at four sites and averaged; concomitantly, peak negative TDI‐derived strain and strain rate of the four walls were measured in apical, four‐, and two‐chamber views. Ejection fraction was 65 ± 6% in C, 62 ± 7% in HFnEF, and 29 ± 7% in SHF (<jats:italic>P</jats:italic>&lt; 0.001 vs. both). In HFnEF patients, systolic velocities and peak negative global longitudinal strain rate and strain were higher than in SHF (<jats:italic>P</jats:italic>&lt; 0.0001 for all), but lower than in C (<jats:italic>P</jats:italic>&lt; 0.0001 for all). After controlling for age, left ventricular mass index, end‐diastolic volume index, and circumferential end‐systolic stress, differences between groups remained significant for deformation indices but not for TDI velocities. By velocity/strain–stress relationship analysis, peak global longitudinal strain was more sensitive than peak systolic motion in detecting systolic dysfunction in HFnEF patients (64 vs. 40%, <jats:italic>P</jats:italic>&lt; 0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In patients with HFnEF, TDI‐derived deformation indices may more accurately detect abnormal systolic function than myocardial velocities.</jats:p></jats:sec>
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author Carluccio, Erberto, Biagioli, Paolo, Alunni, Gianfranco, Murrone, Adriano, Leonelli, Valeria, Pantano, Paola, Biscottini, Emilia, Paulus, Walter J., Ambrosio, Giuseppe
author_facet Carluccio, Erberto, Biagioli, Paolo, Alunni, Gianfranco, Murrone, Adriano, Leonelli, Valeria, Pantano, Paola, Biscottini, Emilia, Paulus, Walter J., Ambrosio, Giuseppe, Carluccio, Erberto, Biagioli, Paolo, Alunni, Gianfranco, Murrone, Adriano, Leonelli, Valeria, Pantano, Paola, Biscottini, Emilia, Paulus, Walter J., Ambrosio, Giuseppe
author_sort carluccio, erberto
container_issue 3
container_start_page 292
container_title European Journal of Heart Failure
container_volume 13
description <jats:sec><jats:title>Aims</jats:title><jats:p>Tissue Doppler imaging (TDI) systolic velocities have been used to detect impaired systolic function in patients with heart failure and normal ejection fraction (HFnEF). However, many patients do not show alterations by this technique, and furthermore, myocardial systolic velocities can be affected by tethering, translation, and loading conditions. Thus, uncertainties remain about the detection of abnormal systolic function in HFnEF patients. The aim of this study was, therefore, to compare systolic velocities vs. TDI‐derived deformation indices for detection of possible abnormalities of systolic function in HFnEF patients, taking into account loading conditions.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>We studied 40 patients with systolic heart failure (SHF: EF ≤40%), 47 HFnEF patients, and 50 controls (C). Systolic velocities of the mitral annulus (pulsed‐wave TDI) were measured at four sites and averaged; concomitantly, peak negative TDI‐derived strain and strain rate of the four walls were measured in apical, four‐, and two‐chamber views. Ejection fraction was 65 ± 6% in C, 62 ± 7% in HFnEF, and 29 ± 7% in SHF (<jats:italic>P</jats:italic>&lt; 0.001 vs. both). In HFnEF patients, systolic velocities and peak negative global longitudinal strain rate and strain were higher than in SHF (<jats:italic>P</jats:italic>&lt; 0.0001 for all), but lower than in C (<jats:italic>P</jats:italic>&lt; 0.0001 for all). After controlling for age, left ventricular mass index, end‐diastolic volume index, and circumferential end‐systolic stress, differences between groups remained significant for deformation indices but not for TDI velocities. By velocity/strain–stress relationship analysis, peak global longitudinal strain was more sensitive than peak systolic motion in detecting systolic dysfunction in HFnEF patients (64 vs. 40%, <jats:italic>P</jats:italic>&lt; 0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In patients with HFnEF, TDI‐derived deformation indices may more accurately detect abnormal systolic function than myocardial velocities.</jats:p></jats:sec>
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spelling Carluccio, Erberto Biagioli, Paolo Alunni, Gianfranco Murrone, Adriano Leonelli, Valeria Pantano, Paola Biscottini, Emilia Paulus, Walter J. Ambrosio, Giuseppe 1388-9842 1879-0844 Wiley Cardiology and Cardiovascular Medicine http://dx.doi.org/10.1093/eurjhf/hfq203 <jats:sec><jats:title>Aims</jats:title><jats:p>Tissue Doppler imaging (TDI) systolic velocities have been used to detect impaired systolic function in patients with heart failure and normal ejection fraction (HFnEF). However, many patients do not show alterations by this technique, and furthermore, myocardial systolic velocities can be affected by tethering, translation, and loading conditions. Thus, uncertainties remain about the detection of abnormal systolic function in HFnEF patients. The aim of this study was, therefore, to compare systolic velocities vs. TDI‐derived deformation indices for detection of possible abnormalities of systolic function in HFnEF patients, taking into account loading conditions.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>We studied 40 patients with systolic heart failure (SHF: EF ≤40%), 47 HFnEF patients, and 50 controls (C). Systolic velocities of the mitral annulus (pulsed‐wave TDI) were measured at four sites and averaged; concomitantly, peak negative TDI‐derived strain and strain rate of the four walls were measured in apical, four‐, and two‐chamber views. Ejection fraction was 65 ± 6% in C, 62 ± 7% in HFnEF, and 29 ± 7% in SHF (<jats:italic>P</jats:italic>&lt; 0.001 vs. both). In HFnEF patients, systolic velocities and peak negative global longitudinal strain rate and strain were higher than in SHF (<jats:italic>P</jats:italic>&lt; 0.0001 for all), but lower than in C (<jats:italic>P</jats:italic>&lt; 0.0001 for all). After controlling for age, left ventricular mass index, end‐diastolic volume index, and circumferential end‐systolic stress, differences between groups remained significant for deformation indices but not for TDI velocities. By velocity/strain–stress relationship analysis, peak global longitudinal strain was more sensitive than peak systolic motion in detecting systolic dysfunction in HFnEF patients (64 vs. 40%, <jats:italic>P</jats:italic>&lt; 0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In patients with HFnEF, TDI‐derived deformation indices may more accurately detect abnormal systolic function than myocardial velocities.</jats:p></jats:sec> Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction European Journal of Heart Failure
spellingShingle Carluccio, Erberto, Biagioli, Paolo, Alunni, Gianfranco, Murrone, Adriano, Leonelli, Valeria, Pantano, Paola, Biscottini, Emilia, Paulus, Walter J., Ambrosio, Giuseppe, European Journal of Heart Failure, Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction, Cardiology and Cardiovascular Medicine
title Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_full Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_fullStr Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_full_unstemmed Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_short Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_sort advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
title_unstemmed Advantages of deformation indices over systolic velocities in assessment of longitudinal systolic function in patients with heart failure and normal ejection fraction
topic Cardiology and Cardiovascular Medicine
url http://dx.doi.org/10.1093/eurjhf/hfq203