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R/qtl: high-throughput multiple QTL mapping
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| Zeitschriftentitel: | Bioinformatics |
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| Personen und Körperschaften: | , , , |
| In: | Bioinformatics, 26, 2010, 23, S. 2990-2992 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>Abstract</jats:title> <jats:p>Motivation: R/qtl is free and powerful software for mapping and exploring quantitative trait loci (QTL). R/qtl provides a fully comprehensive range of methods for a wide range of experimental cross types. We recently added multiple QTL mapping (MQM) to R/qtl. MQM adds higher statistical power to detect and disentangle the effects of multiple linked and unlinked QTL compared with many other methods. MQM for R/qtl adds many new features including improved handling of missing data, analysis of 10 000 s of molecular traits, permutation for determining significance thresholds for QTL and QTL hot spots, and visualizations for cis–trans and QTL interaction effects. MQM for R/qtl is the first free and open source implementation of MQM that is multi-platform, scalable and suitable for automated procedures and large genetical genomics datasets.</jats:p> <jats:p>Availability: R/qtl is free and open source multi-platform software for the statistical language R, and is made available under the GPLv3 license. R/qtl can be installed from http://www.rqtl.org/. R/qtl queries should be directed at the mailing list, see http://www.rqtl.org/list/.</jats:p> <jats:p>Contact: kbroman@biostat.wisc.edu</jats:p> |
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| Umfang: | 2990-2992 |
| ISSN: |
1367-4811
1367-4803 |
| DOI: | 10.1093/bioinformatics/btq565 |