PathGen: a transitive gene pathway generator

Gespeichert in:

Bibliographische Detailangaben
Zeitschriftentitel:	Bioinformatics
Personen und Körperschaften:	Clement, Kendell, Gustafson, Nathaniel, Berbert, Amanda, Carroll, Hyrum, Merris, Christopher, Olsen, Ammon, Clement, Mark, Snell, Quinn, Allen, Jared, Roper, Randall J.
In:	Bioinformatics, 26, 2010, 3, S. 423-425
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Oxford University Press (OUP)
Schlagwörter:	Computational Mathematics Computational Theory and Mathematics Computer Science Applications Molecular Biology Biochemistry Statistics and Probability

Details
Zusammenfassung:	<jats:title>Abstract</jats:title> <jats:p>Summary: Many online sources of gene interaction networks supply rich visual data regarding gene pathways that can aid in the study of biological processes, disease research and drug discovery. PathGen incorporates data from several sources to create transitive connections that span multiple gene interaction databases. Results are displayed in a comprehensible graphical format, showing gene interaction type and strength, database source and microarray expression data. These features make PathGen a valuable tool for in silico discovery of novel gene interaction pathways, which can be experimentally tested and verified. The usefulness of PathGen interaction analyses was validated using genes connected to the altered facial development related to Down syndrome.</jats:p> <jats:p>Availability: http://dna.cs.byu.edu/pathgen</jats:p> <jats:p>Contact: clement@cs.byu.edu</jats:p> <jats:p>Supplementary Information: Supplementary data are available at Bioinformatics online. Further information is available at http://dna.cs.byu.edu/pathgen/PathGenSupplemental.pdf</jats:p>
Umfang:	423-425
ISSN:	1367-4811 1367-4803
DOI:	10.1093/bioinformatics/btp661