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HIPK family kinases bind and regulate the function of the CCR4-NOT complex
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| Zeitschriftentitel: | Molecular Biology of the Cell |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Molecular Biology of the Cell, 27, 2016, 12, S. 1969-1980 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Cell Biology (ASCB)
|
| Schlagwörter: |
| author_facet |
Rodriguez-Gil, Alfonso Ritter, Olesja Hornung, Juliane Stekman, Hilda Krüger, Marcus Braun, Thomas Kremmer, Elisabeth Kracht, Michael Schmitz, M. Lienhard Rodriguez-Gil, Alfonso Ritter, Olesja Hornung, Juliane Stekman, Hilda Krüger, Marcus Braun, Thomas Kremmer, Elisabeth Kracht, Michael Schmitz, M. Lienhard |
|---|---|
| author |
Rodriguez-Gil, Alfonso Ritter, Olesja Hornung, Juliane Stekman, Hilda Krüger, Marcus Braun, Thomas Kremmer, Elisabeth Kracht, Michael Schmitz, M. Lienhard |
| spellingShingle |
Rodriguez-Gil, Alfonso Ritter, Olesja Hornung, Juliane Stekman, Hilda Krüger, Marcus Braun, Thomas Kremmer, Elisabeth Kracht, Michael Schmitz, M. Lienhard Molecular Biology of the Cell HIPK family kinases bind and regulate the function of the CCR4-NOT complex Cell Biology Molecular Biology |
| author_sort |
rodriguez-gil, alfonso |
| spelling |
Rodriguez-Gil, Alfonso Ritter, Olesja Hornung, Juliane Stekman, Hilda Krüger, Marcus Braun, Thomas Kremmer, Elisabeth Kracht, Michael Schmitz, M. Lienhard 1059-1524 1939-4586 American Society for Cell Biology (ASCB) Cell Biology Molecular Biology http://dx.doi.org/10.1091/mbc.e15-09-0629 <jats:p> The serine/threonine kinase HIPK2 functions as a regulator of developmental processes and as a signal integrator of a wide variety of stress signals, such as DNA damage, hypoxia, and reactive oxygen intermediates. Because the kinase is generated in a constitutively active form, its expression levels are restricted by a variety of different mechanisms. Here we identify the CCR4-NOT complex as a new regulator of HIPK2 abundance. Down-regulation or knockout of the CCR4-NOT complex member CNOT2 leads to reduced HIPK2 protein levels without affecting the expression level of HIPK1 or HIPK3. A fraction of all HIPK family members associates with the CCR4-NOT components CNOT2 and CNOT3. HIPKs also phosphorylate the CCR4-NOT complex, a feature that is shared with their yeast progenitor kinase, YAK1. Functional assays reveal that HIPK2 and HIPK1 restrict CNOT2-dependent mRNA decay. HIPKs are well known regulators of transcription, but the mutual regulation between CCR4-NOT and HIPKs extends the regulatory potential of these kinases by enabling posttranscriptional gene regulation. </jats:p> HIPK family kinases bind and regulate the function of the CCR4-NOT complex Molecular Biology of the Cell |
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10.1091/mbc.e15-09-0629 |
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2016 |
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American Society for Cell Biology (ASCB) |
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Molecular Biology of the Cell |
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| title |
HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_unstemmed |
HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_full |
HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_fullStr |
HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_full_unstemmed |
HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_short |
HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_sort |
hipk family kinases bind and regulate the function of the ccr4-not complex |
| topic |
Cell Biology Molecular Biology |
| url |
http://dx.doi.org/10.1091/mbc.e15-09-0629 |
| publishDate |
2016 |
| physical |
1969-1980 |
| description |
<jats:p> The serine/threonine kinase HIPK2 functions as a regulator of developmental processes and as a signal integrator of a wide variety of stress signals, such as DNA damage, hypoxia, and reactive oxygen intermediates. Because the kinase is generated in a constitutively active form, its expression levels are restricted by a variety of different mechanisms. Here we identify the CCR4-NOT complex as a new regulator of HIPK2 abundance. Down-regulation or knockout of the CCR4-NOT complex member CNOT2 leads to reduced HIPK2 protein levels without affecting the expression level of HIPK1 or HIPK3. A fraction of all HIPK family members associates with the CCR4-NOT components CNOT2 and CNOT3. HIPKs also phosphorylate the CCR4-NOT complex, a feature that is shared with their yeast progenitor kinase, YAK1. Functional assays reveal that HIPK2 and HIPK1 restrict CNOT2-dependent mRNA decay. HIPKs are well known regulators of transcription, but the mutual regulation between CCR4-NOT and HIPKs extends the regulatory potential of these kinases by enabling posttranscriptional gene regulation. </jats:p> |
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| author | Rodriguez-Gil, Alfonso, Ritter, Olesja, Hornung, Juliane, Stekman, Hilda, Krüger, Marcus, Braun, Thomas, Kremmer, Elisabeth, Kracht, Michael, Schmitz, M. Lienhard |
| author_facet | Rodriguez-Gil, Alfonso, Ritter, Olesja, Hornung, Juliane, Stekman, Hilda, Krüger, Marcus, Braun, Thomas, Kremmer, Elisabeth, Kracht, Michael, Schmitz, M. Lienhard, Rodriguez-Gil, Alfonso, Ritter, Olesja, Hornung, Juliane, Stekman, Hilda, Krüger, Marcus, Braun, Thomas, Kremmer, Elisabeth, Kracht, Michael, Schmitz, M. Lienhard |
| author_sort | rodriguez-gil, alfonso |
| container_issue | 12 |
| container_start_page | 1969 |
| container_title | Molecular Biology of the Cell |
| container_volume | 27 |
| description | <jats:p> The serine/threonine kinase HIPK2 functions as a regulator of developmental processes and as a signal integrator of a wide variety of stress signals, such as DNA damage, hypoxia, and reactive oxygen intermediates. Because the kinase is generated in a constitutively active form, its expression levels are restricted by a variety of different mechanisms. Here we identify the CCR4-NOT complex as a new regulator of HIPK2 abundance. Down-regulation or knockout of the CCR4-NOT complex member CNOT2 leads to reduced HIPK2 protein levels without affecting the expression level of HIPK1 or HIPK3. A fraction of all HIPK family members associates with the CCR4-NOT components CNOT2 and CNOT3. HIPKs also phosphorylate the CCR4-NOT complex, a feature that is shared with their yeast progenitor kinase, YAK1. Functional assays reveal that HIPK2 and HIPK1 restrict CNOT2-dependent mRNA decay. HIPKs are well known regulators of transcription, but the mutual regulation between CCR4-NOT and HIPKs extends the regulatory potential of these kinases by enabling posttranscriptional gene regulation. </jats:p> |
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| imprint_str_mv | American Society for Cell Biology (ASCB), 2016 |
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| physical | 1969-1980 |
| publishDate | 2016 |
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| series | Molecular Biology of the Cell |
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| spelling | Rodriguez-Gil, Alfonso Ritter, Olesja Hornung, Juliane Stekman, Hilda Krüger, Marcus Braun, Thomas Kremmer, Elisabeth Kracht, Michael Schmitz, M. Lienhard 1059-1524 1939-4586 American Society for Cell Biology (ASCB) Cell Biology Molecular Biology http://dx.doi.org/10.1091/mbc.e15-09-0629 <jats:p> The serine/threonine kinase HIPK2 functions as a regulator of developmental processes and as a signal integrator of a wide variety of stress signals, such as DNA damage, hypoxia, and reactive oxygen intermediates. Because the kinase is generated in a constitutively active form, its expression levels are restricted by a variety of different mechanisms. Here we identify the CCR4-NOT complex as a new regulator of HIPK2 abundance. Down-regulation or knockout of the CCR4-NOT complex member CNOT2 leads to reduced HIPK2 protein levels without affecting the expression level of HIPK1 or HIPK3. A fraction of all HIPK family members associates with the CCR4-NOT components CNOT2 and CNOT3. HIPKs also phosphorylate the CCR4-NOT complex, a feature that is shared with their yeast progenitor kinase, YAK1. Functional assays reveal that HIPK2 and HIPK1 restrict CNOT2-dependent mRNA decay. HIPKs are well known regulators of transcription, but the mutual regulation between CCR4-NOT and HIPKs extends the regulatory potential of these kinases by enabling posttranscriptional gene regulation. </jats:p> HIPK family kinases bind and regulate the function of the CCR4-NOT complex Molecular Biology of the Cell |
| spellingShingle | Rodriguez-Gil, Alfonso, Ritter, Olesja, Hornung, Juliane, Stekman, Hilda, Krüger, Marcus, Braun, Thomas, Kremmer, Elisabeth, Kracht, Michael, Schmitz, M. Lienhard, Molecular Biology of the Cell, HIPK family kinases bind and regulate the function of the CCR4-NOT complex, Cell Biology, Molecular Biology |
| title | HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_full | HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_fullStr | HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_full_unstemmed | HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_short | HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| title_sort | hipk family kinases bind and regulate the function of the ccr4-not complex |
| title_unstemmed | HIPK family kinases bind and regulate the function of the CCR4-NOT complex |
| topic | Cell Biology, Molecular Biology |
| url | http://dx.doi.org/10.1091/mbc.e15-09-0629 |