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The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis
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| Zeitschriftentitel: | Journal of Physics: Conference Series |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Physics: Conference Series, 1246, 2019, 1, S. 012035 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
IOP Publishing
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| Schlagwörter: |
| author_facet |
Umi Partan, Radiyati Hidayat, Rachmat Umi Partan, Radiyati Hidayat, Rachmat |
|---|---|
| author |
Umi Partan, Radiyati Hidayat, Rachmat |
| spellingShingle |
Umi Partan, Radiyati Hidayat, Rachmat Journal of Physics: Conference Series The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis General Physics and Astronomy |
| author_sort |
umi partan, radiyati |
| spelling |
Umi Partan, Radiyati Hidayat, Rachmat 1742-6588 1742-6596 IOP Publishing General Physics and Astronomy http://dx.doi.org/10.1088/1742-6596/1246/1/012035 <jats:title>Abstract</jats:title> <jats:p>Tumour necrosis factor alpha (TNF-α) is an important regulator of bone metabolism. Polymorphisms in the promoter region of the TNF-α gene at position 308 have been identified. We investigated whether these polymorphisms and circulating TNF-a levels were related to BMD in osteoporosis caused by COPD. We conducted this study to analyse the relationship between genetic polymorphism of tumour necrosis factor (TNF)-a -308 G/A and levels of pro-inflammatory cytokines, bone turnover marker levels, and the incidence of osteoporosis in COPD patients. This study was conducted on 70 COPD patients. BMD and bone area of the femoral neck and lumbar spines were measured using dual energy X-ray absorptiometry (Stratos ®). Blood cytokines (TNF-a, interleukin (IL)-6, IL-17, IL-1b) and Ctelopeptide (CTX), receptor activator of nuclear factor kB (RANKL), and osteoprotegerin (OPG) were analysed using ELISA. Polymorphism of the TNF-α gene -308 G/A was assayed by PCR-RFLP. The levels of cytokines were significantly increased in the osteoporosis group compared to those without. Polymorphism was significantly different between COPD with osteoporosis and COPD without. The frequency of the GA and AA genotypes was significantly increased in patients with osteoporosis. To conclude, there is a relationship between the TNF-a -308 G/A polymorphism and high levels of TNF-a, IL-1β, IL-6, IL-17, CTX, and the incidence of osteoporosis in patients with COPD.</jats:p> The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis Journal of Physics: Conference Series |
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| title |
The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_unstemmed |
The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_full |
The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_fullStr |
The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_full_unstemmed |
The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_short |
The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_sort |
the relationship between tnf-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in copd patients with osteoporosis |
| topic |
General Physics and Astronomy |
| url |
http://dx.doi.org/10.1088/1742-6596/1246/1/012035 |
| publishDate |
2019 |
| physical |
012035 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>Tumour necrosis factor alpha (TNF-α) is an important regulator of bone metabolism. Polymorphisms in the promoter region of the TNF-α gene at position 308 have been identified. We investigated whether these polymorphisms and circulating TNF-a levels were related to BMD in osteoporosis caused by COPD. We conducted this study to analyse the relationship between genetic polymorphism of tumour necrosis factor (TNF)-a -308 G/A and levels of pro-inflammatory cytokines, bone turnover marker levels, and the incidence of osteoporosis in COPD patients. This study was conducted on 70 COPD patients. BMD and bone area of the femoral neck and lumbar spines were measured using dual energy X-ray absorptiometry (Stratos ®). Blood cytokines (TNF-a, interleukin (IL)-6, IL-17, IL-1b) and Ctelopeptide (CTX), receptor activator of nuclear factor kB (RANKL), and osteoprotegerin (OPG) were analysed using ELISA. Polymorphism of the TNF-α gene -308 G/A was assayed by PCR-RFLP. The levels of cytokines were significantly increased in the osteoporosis group compared to those without. Polymorphism was significantly different between COPD with osteoporosis and COPD without. The frequency of the GA and AA genotypes was significantly increased in patients with osteoporosis. To conclude, there is a relationship between the TNF-a -308 G/A polymorphism and high levels of TNF-a, IL-1β, IL-6, IL-17, CTX, and the incidence of osteoporosis in patients with COPD.</jats:p> |
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| author | Umi Partan, Radiyati, Hidayat, Rachmat |
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| description | <jats:title>Abstract</jats:title> <jats:p>Tumour necrosis factor alpha (TNF-α) is an important regulator of bone metabolism. Polymorphisms in the promoter region of the TNF-α gene at position 308 have been identified. We investigated whether these polymorphisms and circulating TNF-a levels were related to BMD in osteoporosis caused by COPD. We conducted this study to analyse the relationship between genetic polymorphism of tumour necrosis factor (TNF)-a -308 G/A and levels of pro-inflammatory cytokines, bone turnover marker levels, and the incidence of osteoporosis in COPD patients. This study was conducted on 70 COPD patients. BMD and bone area of the femoral neck and lumbar spines were measured using dual energy X-ray absorptiometry (Stratos ®). Blood cytokines (TNF-a, interleukin (IL)-6, IL-17, IL-1b) and Ctelopeptide (CTX), receptor activator of nuclear factor kB (RANKL), and osteoprotegerin (OPG) were analysed using ELISA. Polymorphism of the TNF-α gene -308 G/A was assayed by PCR-RFLP. The levels of cytokines were significantly increased in the osteoporosis group compared to those without. Polymorphism was significantly different between COPD with osteoporosis and COPD without. The frequency of the GA and AA genotypes was significantly increased in patients with osteoporosis. To conclude, there is a relationship between the TNF-a -308 G/A polymorphism and high levels of TNF-a, IL-1β, IL-6, IL-17, CTX, and the incidence of osteoporosis in patients with COPD.</jats:p> |
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| spelling | Umi Partan, Radiyati Hidayat, Rachmat 1742-6588 1742-6596 IOP Publishing General Physics and Astronomy http://dx.doi.org/10.1088/1742-6596/1246/1/012035 <jats:title>Abstract</jats:title> <jats:p>Tumour necrosis factor alpha (TNF-α) is an important regulator of bone metabolism. Polymorphisms in the promoter region of the TNF-α gene at position 308 have been identified. We investigated whether these polymorphisms and circulating TNF-a levels were related to BMD in osteoporosis caused by COPD. We conducted this study to analyse the relationship between genetic polymorphism of tumour necrosis factor (TNF)-a -308 G/A and levels of pro-inflammatory cytokines, bone turnover marker levels, and the incidence of osteoporosis in COPD patients. This study was conducted on 70 COPD patients. BMD and bone area of the femoral neck and lumbar spines were measured using dual energy X-ray absorptiometry (Stratos ®). Blood cytokines (TNF-a, interleukin (IL)-6, IL-17, IL-1b) and Ctelopeptide (CTX), receptor activator of nuclear factor kB (RANKL), and osteoprotegerin (OPG) were analysed using ELISA. Polymorphism of the TNF-α gene -308 G/A was assayed by PCR-RFLP. The levels of cytokines were significantly increased in the osteoporosis group compared to those without. Polymorphism was significantly different between COPD with osteoporosis and COPD without. The frequency of the GA and AA genotypes was significantly increased in patients with osteoporosis. To conclude, there is a relationship between the TNF-a -308 G/A polymorphism and high levels of TNF-a, IL-1β, IL-6, IL-17, CTX, and the incidence of osteoporosis in patients with COPD.</jats:p> The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis Journal of Physics: Conference Series |
| spellingShingle | Umi Partan, Radiyati, Hidayat, Rachmat, Journal of Physics: Conference Series, The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis, General Physics and Astronomy |
| title | The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_full | The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_fullStr | The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_full_unstemmed | The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_short | The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| title_sort | the relationship between tnf-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in copd patients with osteoporosis |
| title_unstemmed | The relationship between TNF-α gene polymorphism, pro-inflammatory cytokines and bone turnover markers in COPD patients with osteoporosis |
| topic | General Physics and Astronomy |
| url | http://dx.doi.org/10.1088/1742-6596/1246/1/012035 |