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Anion Permeability of Frog Skeletal Muscle
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| Zeitschriftentitel: | The Journal of General Physiology |
|---|---|
| Personen und Körperschaften: | |
| In: | The Journal of General Physiology, 54, 1969, 1, S. 33-52 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
|
| Schlagwörter: |
| author_facet |
Moore, L. E. Moore, L. E. |
|---|---|
| author |
Moore, L. E. |
| spellingShingle |
Moore, L. E. The Journal of General Physiology Anion Permeability of Frog Skeletal Muscle Physiology |
| author_sort |
moore, l. e. |
| spelling |
Moore, L. E. 1540-7748 0022-1295 Rockefeller University Press Physiology http://dx.doi.org/10.1085/jgp.54.1.33 <jats:p>Unidirectional chloride effluxes from small bundles of muscle fibers were measured under equilibrium conditions. It was found that chloride effluxes are described by the constant field theory with a chloride permeability constant, Pcl, which is independent of the chloride concentration and the membrane potential. The value of Pcl at neutral pH was found to be 5 x 10-6 cm/sec. Chloride movements were markedly depressed at low pH and increased at high pH. It is concluded that chloride fluxes are independent of each other over a wide pH range. The effect of nitrate on the chloride effluxes was measured. It was found that both external and internal nitrate alone reduced the chloride efflux with the external nitrate appearing more effective than internal nitrate due to the nonequilibrium nature of the experimental conditions. Under equilibrium conditions the reduction of the chloride efflux by nitrate was greater than the external nitrate effect, both of which were dependent on the relative proportion of nitrate in the bathing solution. These results are consistent with the hypothesis that the inhibition of the chloride movements by nitrate is essentially symmetrical with regard to the inside and outside surfaces of the muscle membranes. The relative action of nitrate on the chloride efflux was independent of the external pH despite marked changes in the absolute values of the fluxes measured.</jats:p> Anion Permeability of Frog Skeletal Muscle The Journal of General Physiology |
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Rockefeller University Press, 1969 |
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Rockefeller University Press, 1969 |
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1540-7748 0022-1295 |
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1969 |
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Rockefeller University Press |
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The Journal of General Physiology |
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49 |
| title |
Anion Permeability of Frog Skeletal Muscle |
| title_unstemmed |
Anion Permeability of Frog Skeletal Muscle |
| title_full |
Anion Permeability of Frog Skeletal Muscle |
| title_fullStr |
Anion Permeability of Frog Skeletal Muscle |
| title_full_unstemmed |
Anion Permeability of Frog Skeletal Muscle |
| title_short |
Anion Permeability of Frog Skeletal Muscle |
| title_sort |
anion permeability of frog skeletal muscle |
| topic |
Physiology |
| url |
http://dx.doi.org/10.1085/jgp.54.1.33 |
| publishDate |
1969 |
| physical |
33-52 |
| description |
<jats:p>Unidirectional chloride effluxes from small bundles of muscle fibers were measured under equilibrium conditions. It was found that chloride effluxes are described by the constant field theory with a chloride permeability constant, Pcl, which is independent of the chloride concentration and the membrane potential. The value of Pcl at neutral pH was found to be 5 x 10-6 cm/sec. Chloride movements were markedly depressed at low pH and increased at high pH. It is concluded that chloride fluxes are independent of each other over a wide pH range. The effect of nitrate on the chloride effluxes was measured. It was found that both external and internal nitrate alone reduced the chloride efflux with the external nitrate appearing more effective than internal nitrate due to the nonequilibrium nature of the experimental conditions. Under equilibrium conditions the reduction of the chloride efflux by nitrate was greater than the external nitrate effect, both of which were dependent on the relative proportion of nitrate in the bathing solution. These results are consistent with the hypothesis that the inhibition of the chloride movements by nitrate is essentially symmetrical with regard to the inside and outside surfaces of the muscle membranes. The relative action of nitrate on the chloride efflux was independent of the external pH despite marked changes in the absolute values of the fluxes measured.</jats:p> |
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| author | Moore, L. E. |
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| container_title | The Journal of General Physiology |
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| description | <jats:p>Unidirectional chloride effluxes from small bundles of muscle fibers were measured under equilibrium conditions. It was found that chloride effluxes are described by the constant field theory with a chloride permeability constant, Pcl, which is independent of the chloride concentration and the membrane potential. The value of Pcl at neutral pH was found to be 5 x 10-6 cm/sec. Chloride movements were markedly depressed at low pH and increased at high pH. It is concluded that chloride fluxes are independent of each other over a wide pH range. The effect of nitrate on the chloride effluxes was measured. It was found that both external and internal nitrate alone reduced the chloride efflux with the external nitrate appearing more effective than internal nitrate due to the nonequilibrium nature of the experimental conditions. Under equilibrium conditions the reduction of the chloride efflux by nitrate was greater than the external nitrate effect, both of which were dependent on the relative proportion of nitrate in the bathing solution. These results are consistent with the hypothesis that the inhibition of the chloride movements by nitrate is essentially symmetrical with regard to the inside and outside surfaces of the muscle membranes. The relative action of nitrate on the chloride efflux was independent of the external pH despite marked changes in the absolute values of the fluxes measured.</jats:p> |
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| imprint | Rockefeller University Press, 1969 |
| imprint_str_mv | Rockefeller University Press, 1969 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229 |
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| language | English |
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| physical | 33-52 |
| publishDate | 1969 |
| publishDateSort | 1969 |
| publisher | Rockefeller University Press |
| record_format | ai |
| recordtype | ai |
| series | The Journal of General Physiology |
| source_id | 49 |
| spelling | Moore, L. E. 1540-7748 0022-1295 Rockefeller University Press Physiology http://dx.doi.org/10.1085/jgp.54.1.33 <jats:p>Unidirectional chloride effluxes from small bundles of muscle fibers were measured under equilibrium conditions. It was found that chloride effluxes are described by the constant field theory with a chloride permeability constant, Pcl, which is independent of the chloride concentration and the membrane potential. The value of Pcl at neutral pH was found to be 5 x 10-6 cm/sec. Chloride movements were markedly depressed at low pH and increased at high pH. It is concluded that chloride fluxes are independent of each other over a wide pH range. The effect of nitrate on the chloride effluxes was measured. It was found that both external and internal nitrate alone reduced the chloride efflux with the external nitrate appearing more effective than internal nitrate due to the nonequilibrium nature of the experimental conditions. Under equilibrium conditions the reduction of the chloride efflux by nitrate was greater than the external nitrate effect, both of which were dependent on the relative proportion of nitrate in the bathing solution. These results are consistent with the hypothesis that the inhibition of the chloride movements by nitrate is essentially symmetrical with regard to the inside and outside surfaces of the muscle membranes. The relative action of nitrate on the chloride efflux was independent of the external pH despite marked changes in the absolute values of the fluxes measured.</jats:p> Anion Permeability of Frog Skeletal Muscle The Journal of General Physiology |
| spellingShingle | Moore, L. E., The Journal of General Physiology, Anion Permeability of Frog Skeletal Muscle, Physiology |
| title | Anion Permeability of Frog Skeletal Muscle |
| title_full | Anion Permeability of Frog Skeletal Muscle |
| title_fullStr | Anion Permeability of Frog Skeletal Muscle |
| title_full_unstemmed | Anion Permeability of Frog Skeletal Muscle |
| title_short | Anion Permeability of Frog Skeletal Muscle |
| title_sort | anion permeability of frog skeletal muscle |
| title_unstemmed | Anion Permeability of Frog Skeletal Muscle |
| topic | Physiology |
| url | http://dx.doi.org/10.1085/jgp.54.1.33 |