Eintrag weiter verarbeiten
TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease
Gespeichert in:
| Zeitschriftentitel: | The Journal of Experimental Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | The Journal of Experimental Medicine, 201, 2005, 10, S. 1647-1657 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
|
| Schlagwörter: |
| author_facet |
El-Asady, Riham Yuan, Rongwen Liu, Kechang Wang, Donghua Gress, Ronald E. Lucas, Philip J. Drachenberg, Cinthia B. Hadley, Gregg A. El-Asady, Riham Yuan, Rongwen Liu, Kechang Wang, Donghua Gress, Ronald E. Lucas, Philip J. Drachenberg, Cinthia B. Hadley, Gregg A. |
|---|---|
| author |
El-Asady, Riham Yuan, Rongwen Liu, Kechang Wang, Donghua Gress, Ronald E. Lucas, Philip J. Drachenberg, Cinthia B. Hadley, Gregg A. |
| spellingShingle |
El-Asady, Riham Yuan, Rongwen Liu, Kechang Wang, Donghua Gress, Ronald E. Lucas, Philip J. Drachenberg, Cinthia B. Hadley, Gregg A. The Journal of Experimental Medicine TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease Immunology Immunology and Allergy |
| author_sort |
el-asady, riham |
| spelling |
El-Asady, Riham Yuan, Rongwen Liu, Kechang Wang, Donghua Gress, Ronald E. Lucas, Philip J. Drachenberg, Cinthia B. Hadley, Gregg A. 1540-9538 0022-1007 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.20041044 <jats:p>Destruction of the host intestinal epithelium by donor effector T cell populations is a hallmark of graft-versus-host disease (GVHD), but the underlying mechanisms remain obscure. We demonstrate that CD8+ T cells expressing CD103, an integrin conferring specificity for the epithelial ligand E-cadherin, play a critical role in this process. A TCR transgenic GVHD model was used to demonstrate that CD103 is selectively expressed by host-specific CD8+ T cell effector populations (CD8 effectors) that accumulate in the host intestinal epithelium during GVHD. Although host-specific CD8 effectors infiltrated a wide range of host compartments, only those infiltrating the intestinal epithelium expressed CD103. Host-specific CD8 effectors expressing a TGF-β dominant negative type II receptor were defective in CD103 expression on entry into the intestinal epithelium, which indicates local TGF-β activity as a critical regulating factor. Host-specific CD8 effectors deficient in CD103 expression successfully migrated into the host intestinal epithelium but were retained at this site much less efficiently than wild-type host-specific CD8 effectors. The relevance of these events to GVHD pathogenesis is supported by the finding that CD103-deficient CD8+ T cells were strikingly defective in transferring intestinal GVHD pathology and mortality. Collectively, these data document a pivotal role for TGF-β–dependent CD103 expression in dictating the gut tropism, and hence the destructive potential, of CD8+ T cells during GVHD pathogenesis.</jats:p> TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease The Journal of Experimental Medicine |
| doi_str_mv |
10.1084/jem.20041044 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMjAwNDEwNDQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMjAwNDEwNDQ |
| institution |
DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-105 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Rockefeller University Press, 2005 |
| imprint_str_mv |
Rockefeller University Press, 2005 |
| issn |
1540-9538 0022-1007 |
| issn_str_mv |
1540-9538 0022-1007 |
| language |
English |
| mega_collection |
Rockefeller University Press (CrossRef) |
| match_str |
elasady2005tgfbdependentcd103expressionbycd8tcellspromotesselectivedestructionofthehostintestinalepitheliumduringgraftversushostdisease |
| publishDateSort |
2005 |
| publisher |
Rockefeller University Press |
| recordtype |
ai |
| record_format |
ai |
| series |
The Journal of Experimental Medicine |
| source_id |
49 |
| title |
TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_unstemmed |
TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_full |
TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_fullStr |
TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_full_unstemmed |
TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_short |
TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_sort |
tgf-β–dependent cd103 expression by cd8+ t cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1084/jem.20041044 |
| publishDate |
2005 |
| physical |
1647-1657 |
| description |
<jats:p>Destruction of the host intestinal epithelium by donor effector T cell populations is a hallmark of graft-versus-host disease (GVHD), but the underlying mechanisms remain obscure. We demonstrate that CD8+ T cells expressing CD103, an integrin conferring specificity for the epithelial ligand E-cadherin, play a critical role in this process. A TCR transgenic GVHD model was used to demonstrate that CD103 is selectively expressed by host-specific CD8+ T cell effector populations (CD8 effectors) that accumulate in the host intestinal epithelium during GVHD. Although host-specific CD8 effectors infiltrated a wide range of host compartments, only those infiltrating the intestinal epithelium expressed CD103. Host-specific CD8 effectors expressing a TGF-β dominant negative type II receptor were defective in CD103 expression on entry into the intestinal epithelium, which indicates local TGF-β activity as a critical regulating factor. Host-specific CD8 effectors deficient in CD103 expression successfully migrated into the host intestinal epithelium but were retained at this site much less efficiently than wild-type host-specific CD8 effectors. The relevance of these events to GVHD pathogenesis is supported by the finding that CD103-deficient CD8+ T cells were strikingly defective in transferring intestinal GVHD pathology and mortality. Collectively, these data document a pivotal role for TGF-β–dependent CD103 expression in dictating the gut tropism, and hence the destructive potential, of CD8+ T cells during GVHD pathogenesis.</jats:p> |
| container_issue |
10 |
| container_start_page |
1647 |
| container_title |
The Journal of Experimental Medicine |
| container_volume |
201 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792345421575618560 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:23:12.539Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=TGF-%CE%B2%E2%80%93dependent+CD103+expression+by+CD8%2B+T+cells+promotes+selective+destruction+of+the+host+intestinal+epithelium+during+graft-versus-host+disease&rft.date=2005-05-16&genre=article&issn=0022-1007&volume=201&issue=10&spage=1647&epage=1657&pages=1647-1657&jtitle=The+Journal+of+Experimental+Medicine&atitle=TGF-%CE%B2%E2%80%93dependent+CD103+expression+by+CD8%2B+T+cells+promotes+selective+destruction+of+the+host+intestinal+epithelium+during+graft-versus-host+disease&aulast=Hadley&aufirst=Gregg+A.&rft_id=info%3Adoi%2F10.1084%2Fjem.20041044&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792345421575618560 |
| author | El-Asady, Riham, Yuan, Rongwen, Liu, Kechang, Wang, Donghua, Gress, Ronald E., Lucas, Philip J., Drachenberg, Cinthia B., Hadley, Gregg A. |
| author_facet | El-Asady, Riham, Yuan, Rongwen, Liu, Kechang, Wang, Donghua, Gress, Ronald E., Lucas, Philip J., Drachenberg, Cinthia B., Hadley, Gregg A., El-Asady, Riham, Yuan, Rongwen, Liu, Kechang, Wang, Donghua, Gress, Ronald E., Lucas, Philip J., Drachenberg, Cinthia B., Hadley, Gregg A. |
| author_sort | el-asady, riham |
| container_issue | 10 |
| container_start_page | 1647 |
| container_title | The Journal of Experimental Medicine |
| container_volume | 201 |
| description | <jats:p>Destruction of the host intestinal epithelium by donor effector T cell populations is a hallmark of graft-versus-host disease (GVHD), but the underlying mechanisms remain obscure. We demonstrate that CD8+ T cells expressing CD103, an integrin conferring specificity for the epithelial ligand E-cadherin, play a critical role in this process. A TCR transgenic GVHD model was used to demonstrate that CD103 is selectively expressed by host-specific CD8+ T cell effector populations (CD8 effectors) that accumulate in the host intestinal epithelium during GVHD. Although host-specific CD8 effectors infiltrated a wide range of host compartments, only those infiltrating the intestinal epithelium expressed CD103. Host-specific CD8 effectors expressing a TGF-β dominant negative type II receptor were defective in CD103 expression on entry into the intestinal epithelium, which indicates local TGF-β activity as a critical regulating factor. Host-specific CD8 effectors deficient in CD103 expression successfully migrated into the host intestinal epithelium but were retained at this site much less efficiently than wild-type host-specific CD8 effectors. The relevance of these events to GVHD pathogenesis is supported by the finding that CD103-deficient CD8+ T cells were strikingly defective in transferring intestinal GVHD pathology and mortality. Collectively, these data document a pivotal role for TGF-β–dependent CD103 expression in dictating the gut tropism, and hence the destructive potential, of CD8+ T cells during GVHD pathogenesis.</jats:p> |
| doi_str_mv | 10.1084/jem.20041044 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMjAwNDEwNDQ |
| imprint | Rockefeller University Press, 2005 |
| imprint_str_mv | Rockefeller University Press, 2005 |
| institution | DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 1540-9538, 0022-1007 |
| issn_str_mv | 1540-9538, 0022-1007 |
| language | English |
| last_indexed | 2024-03-01T17:23:12.539Z |
| match_str | elasady2005tgfbdependentcd103expressionbycd8tcellspromotesselectivedestructionofthehostintestinalepitheliumduringgraftversushostdisease |
| mega_collection | Rockefeller University Press (CrossRef) |
| physical | 1647-1657 |
| publishDate | 2005 |
| publishDateSort | 2005 |
| publisher | Rockefeller University Press |
| record_format | ai |
| recordtype | ai |
| series | The Journal of Experimental Medicine |
| source_id | 49 |
| spelling | El-Asady, Riham Yuan, Rongwen Liu, Kechang Wang, Donghua Gress, Ronald E. Lucas, Philip J. Drachenberg, Cinthia B. Hadley, Gregg A. 1540-9538 0022-1007 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.20041044 <jats:p>Destruction of the host intestinal epithelium by donor effector T cell populations is a hallmark of graft-versus-host disease (GVHD), but the underlying mechanisms remain obscure. We demonstrate that CD8+ T cells expressing CD103, an integrin conferring specificity for the epithelial ligand E-cadherin, play a critical role in this process. A TCR transgenic GVHD model was used to demonstrate that CD103 is selectively expressed by host-specific CD8+ T cell effector populations (CD8 effectors) that accumulate in the host intestinal epithelium during GVHD. Although host-specific CD8 effectors infiltrated a wide range of host compartments, only those infiltrating the intestinal epithelium expressed CD103. Host-specific CD8 effectors expressing a TGF-β dominant negative type II receptor were defective in CD103 expression on entry into the intestinal epithelium, which indicates local TGF-β activity as a critical regulating factor. Host-specific CD8 effectors deficient in CD103 expression successfully migrated into the host intestinal epithelium but were retained at this site much less efficiently than wild-type host-specific CD8 effectors. The relevance of these events to GVHD pathogenesis is supported by the finding that CD103-deficient CD8+ T cells were strikingly defective in transferring intestinal GVHD pathology and mortality. Collectively, these data document a pivotal role for TGF-β–dependent CD103 expression in dictating the gut tropism, and hence the destructive potential, of CD8+ T cells during GVHD pathogenesis.</jats:p> TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease The Journal of Experimental Medicine |
| spellingShingle | El-Asady, Riham, Yuan, Rongwen, Liu, Kechang, Wang, Donghua, Gress, Ronald E., Lucas, Philip J., Drachenberg, Cinthia B., Hadley, Gregg A., The Journal of Experimental Medicine, TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease, Immunology, Immunology and Allergy |
| title | TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_full | TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_fullStr | TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_full_unstemmed | TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_short | TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_sort | tgf-β–dependent cd103 expression by cd8+ t cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| title_unstemmed | TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1084/jem.20041044 |