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Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters
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| Zeitschriftentitel: | The Journal of Experimental Medicine |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | The Journal of Experimental Medicine, 199, 2004, 2, S. 155-166 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
|
| Schlagwörter: |
| author_facet |
Gotter, Jörn Brors, Benedikt Hergenhahn, Manfred Kyewski, Bruno Gotter, Jörn Brors, Benedikt Hergenhahn, Manfred Kyewski, Bruno |
|---|---|
| author |
Gotter, Jörn Brors, Benedikt Hergenhahn, Manfred Kyewski, Bruno |
| spellingShingle |
Gotter, Jörn Brors, Benedikt Hergenhahn, Manfred Kyewski, Bruno The Journal of Experimental Medicine Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters Immunology Immunology and Allergy |
| author_sort |
gotter, jörn |
| spelling |
Gotter, Jörn Brors, Benedikt Hergenhahn, Manfred Kyewski, Bruno 1540-9538 0022-1007 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.20031677 <jats:p>Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in animal studies. Analysis of promiscuous gene expression in purified stromal cells of the human thymus at the single and global gene level documents the species conservation of this phenomenon. Medullary thymic epithelial cells overexpress a highly diverse set of genes (&gt;400) including many tissue-specific antigens, disease-associated autoantigens, and cancer-germline genes. Although there are no apparent structural or functional commonalities among these genes and their products, they cluster along chromosomes. These findings have implications for human autoimmune diseases, immuno-therapy of tumors, and the understanding of the nature of this unorthodox regulation of gene expression.</jats:p> Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters The Journal of Experimental Medicine |
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| title |
Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_unstemmed |
Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_full |
Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_fullStr |
Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_full_unstemmed |
Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_short |
Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_sort |
medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1084/jem.20031677 |
| publishDate |
2004 |
| physical |
155-166 |
| description |
<jats:p>Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in animal studies. Analysis of promiscuous gene expression in purified stromal cells of the human thymus at the single and global gene level documents the species conservation of this phenomenon. Medullary thymic epithelial cells overexpress a highly diverse set of genes (&gt;400) including many tissue-specific antigens, disease-associated autoantigens, and cancer-germline genes. Although there are no apparent structural or functional commonalities among these genes and their products, they cluster along chromosomes. These findings have implications for human autoimmune diseases, immuno-therapy of tumors, and the understanding of the nature of this unorthodox regulation of gene expression.</jats:p> |
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| author | Gotter, Jörn, Brors, Benedikt, Hergenhahn, Manfred, Kyewski, Bruno |
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| description | <jats:p>Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in animal studies. Analysis of promiscuous gene expression in purified stromal cells of the human thymus at the single and global gene level documents the species conservation of this phenomenon. Medullary thymic epithelial cells overexpress a highly diverse set of genes (&gt;400) including many tissue-specific antigens, disease-associated autoantigens, and cancer-germline genes. Although there are no apparent structural or functional commonalities among these genes and their products, they cluster along chromosomes. These findings have implications for human autoimmune diseases, immuno-therapy of tumors, and the understanding of the nature of this unorthodox regulation of gene expression.</jats:p> |
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| imprint | Rockefeller University Press, 2004 |
| imprint_str_mv | Rockefeller University Press, 2004 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
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| spelling | Gotter, Jörn Brors, Benedikt Hergenhahn, Manfred Kyewski, Bruno 1540-9538 0022-1007 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.20031677 <jats:p>Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in animal studies. Analysis of promiscuous gene expression in purified stromal cells of the human thymus at the single and global gene level documents the species conservation of this phenomenon. Medullary thymic epithelial cells overexpress a highly diverse set of genes (&gt;400) including many tissue-specific antigens, disease-associated autoantigens, and cancer-germline genes. Although there are no apparent structural or functional commonalities among these genes and their products, they cluster along chromosomes. These findings have implications for human autoimmune diseases, immuno-therapy of tumors, and the understanding of the nature of this unorthodox regulation of gene expression.</jats:p> Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters The Journal of Experimental Medicine |
| spellingShingle | Gotter, Jörn, Brors, Benedikt, Hergenhahn, Manfred, Kyewski, Bruno, The Journal of Experimental Medicine, Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters, Immunology, Immunology and Allergy |
| title | Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_full | Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_fullStr | Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_full_unstemmed | Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_short | Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| title_sort | medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters |
| title_unstemmed | Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1084/jem.20031677 |