Eintrag weiter verarbeiten
The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation.
Gespeichert in:
| Zeitschriftentitel: | The Journal of experimental medicine |
|---|---|
| Personen und Körperschaften: | , , |
| In: | The Journal of experimental medicine, 183, 1996, 6, S. 2427-2436 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
|
| Schlagwörter: |
| author_facet |
Wang, B Benoist, C Mathis, D Wang, B Benoist, C Mathis, D |
|---|---|
| author |
Wang, B Benoist, C Mathis, D |
| spellingShingle |
Wang, B Benoist, C Mathis, D The Journal of experimental medicine The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. Immunology Immunology and Allergy |
| author_sort |
wang, b |
| spelling |
Wang, B Benoist, C Mathis, D 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.183.6.2427 <jats:p>15 [correction of 1,5] deoxyspergualin (DSG) is a potent immunosuppressant whose mechanism of action is still somewhat of a mystery. We have studied the generation of lymphocytes in mice treated with this drug. The differentiation of T cells in the thymus was blocked at an important early control point: the CD4-8- --&gt; CD4+8+ transition, known to depend on the expression of a preTCR complex that includes the variable TCR-beta, but not TCR-alpha, chain. In clear contrast, a later control point, the CD4+8+ --&gt; CD4+8- or CD4-8+ transition, dependent on the display of a conventional alpha:beta TCR complex, appeared unaffected, as did activation of mature T cells both in vitro and in vivo. Interestingly, preB cell differentiation in the bone marrow was blocked at a precisely equivalent point: the A-C --&gt; C' transition, controlled by expression of a pre-receptor complex containing the Ig heavy, but not light, chain. Mature B cells seemed unperturbed. These findings have theoretical implications, suggesting common signaling pathways in early lymphocytes that are distinct from those employed by more mature cells, and are also of practical interest, to be considered in the design of DSG treatment protocols.</jats:p> The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. The Journal of experimental medicine |
| doi_str_mv |
10.1084/jem.183.6.2427 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMTgzLjYuMjQyNw |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMTgzLjYuMjQyNw |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Rockefeller University Press, 1996 |
| imprint_str_mv |
Rockefeller University Press, 1996 |
| issn |
1540-9538 0022-1007 |
| issn_str_mv |
1540-9538 0022-1007 |
| language |
English |
| mega_collection |
Rockefeller University Press (CrossRef) |
| match_str |
wang1996theimmunosuppressant15deoxyspergualincorrectionof15deoxyspergualinrevealscommonalitybetweenpretandprebcelldifferentiation |
| publishDateSort |
1996 |
| publisher |
Rockefeller University Press |
| recordtype |
ai |
| record_format |
ai |
| series |
The Journal of experimental medicine |
| source_id |
49 |
| title |
The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_unstemmed |
The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_full |
The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_fullStr |
The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_full_unstemmed |
The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_short |
The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_sort |
the immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between pret and preb cell differentiation. |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1084/jem.183.6.2427 |
| publishDate |
1996 |
| physical |
2427-2436 |
| description |
<jats:p>15 [correction of 1,5] deoxyspergualin (DSG) is a potent immunosuppressant whose mechanism of action is still somewhat of a mystery. We have studied the generation of lymphocytes in mice treated with this drug. The differentiation of T cells in the thymus was blocked at an important early control point: the CD4-8- --&gt; CD4+8+ transition, known to depend on the expression of a preTCR complex that includes the variable TCR-beta, but not TCR-alpha, chain. In clear contrast, a later control point, the CD4+8+ --&gt; CD4+8- or CD4-8+ transition, dependent on the display of a conventional alpha:beta TCR complex, appeared unaffected, as did activation of mature T cells both in vitro and in vivo. Interestingly, preB cell differentiation in the bone marrow was blocked at a precisely equivalent point: the A-C --&gt; C' transition, controlled by expression of a pre-receptor complex containing the Ig heavy, but not light, chain. Mature B cells seemed unperturbed. These findings have theoretical implications, suggesting common signaling pathways in early lymphocytes that are distinct from those employed by more mature cells, and are also of practical interest, to be considered in the design of DSG treatment protocols.</jats:p> |
| container_issue |
6 |
| container_start_page |
2427 |
| container_title |
The Journal of experimental medicine |
| container_volume |
183 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792332276230520842 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T13:54:13.861Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=The+immunosuppressant+15-deoxyspergualin+%5Bcorrection+of+1%2C5-deoxyspergualin%5D+reveals+commonality+between+preT+and+preB+cell+differentiation.&rft.date=1996-06-01&genre=article&issn=1540-9538&volume=183&issue=6&spage=2427&epage=2436&pages=2427-2436&jtitle=The+Journal+of+experimental+medicine&atitle=The+immunosuppressant+15-deoxyspergualin+%5Bcorrection+of+1%2C5-deoxyspergualin%5D+reveals+commonality+between+preT+and+preB+cell+differentiation.&aulast=Mathis&aufirst=D&rft_id=info%3Adoi%2F10.1084%2Fjem.183.6.2427&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792332276230520842 |
| author | Wang, B, Benoist, C, Mathis, D |
| author_facet | Wang, B, Benoist, C, Mathis, D, Wang, B, Benoist, C, Mathis, D |
| author_sort | wang, b |
| container_issue | 6 |
| container_start_page | 2427 |
| container_title | The Journal of experimental medicine |
| container_volume | 183 |
| description | <jats:p>15 [correction of 1,5] deoxyspergualin (DSG) is a potent immunosuppressant whose mechanism of action is still somewhat of a mystery. We have studied the generation of lymphocytes in mice treated with this drug. The differentiation of T cells in the thymus was blocked at an important early control point: the CD4-8- --&gt; CD4+8+ transition, known to depend on the expression of a preTCR complex that includes the variable TCR-beta, but not TCR-alpha, chain. In clear contrast, a later control point, the CD4+8+ --&gt; CD4+8- or CD4-8+ transition, dependent on the display of a conventional alpha:beta TCR complex, appeared unaffected, as did activation of mature T cells both in vitro and in vivo. Interestingly, preB cell differentiation in the bone marrow was blocked at a precisely equivalent point: the A-C --&gt; C' transition, controlled by expression of a pre-receptor complex containing the Ig heavy, but not light, chain. Mature B cells seemed unperturbed. These findings have theoretical implications, suggesting common signaling pathways in early lymphocytes that are distinct from those employed by more mature cells, and are also of practical interest, to be considered in the design of DSG treatment protocols.</jats:p> |
| doi_str_mv | 10.1084/jem.183.6.2427 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMTgzLjYuMjQyNw |
| imprint | Rockefeller University Press, 1996 |
| imprint_str_mv | Rockefeller University Press, 1996 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 1540-9538, 0022-1007 |
| issn_str_mv | 1540-9538, 0022-1007 |
| language | English |
| last_indexed | 2024-03-01T13:54:13.861Z |
| match_str | wang1996theimmunosuppressant15deoxyspergualincorrectionof15deoxyspergualinrevealscommonalitybetweenpretandprebcelldifferentiation |
| mega_collection | Rockefeller University Press (CrossRef) |
| physical | 2427-2436 |
| publishDate | 1996 |
| publishDateSort | 1996 |
| publisher | Rockefeller University Press |
| record_format | ai |
| recordtype | ai |
| series | The Journal of experimental medicine |
| source_id | 49 |
| spelling | Wang, B Benoist, C Mathis, D 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.183.6.2427 <jats:p>15 [correction of 1,5] deoxyspergualin (DSG) is a potent immunosuppressant whose mechanism of action is still somewhat of a mystery. We have studied the generation of lymphocytes in mice treated with this drug. The differentiation of T cells in the thymus was blocked at an important early control point: the CD4-8- --&gt; CD4+8+ transition, known to depend on the expression of a preTCR complex that includes the variable TCR-beta, but not TCR-alpha, chain. In clear contrast, a later control point, the CD4+8+ --&gt; CD4+8- or CD4-8+ transition, dependent on the display of a conventional alpha:beta TCR complex, appeared unaffected, as did activation of mature T cells both in vitro and in vivo. Interestingly, preB cell differentiation in the bone marrow was blocked at a precisely equivalent point: the A-C --&gt; C' transition, controlled by expression of a pre-receptor complex containing the Ig heavy, but not light, chain. Mature B cells seemed unperturbed. These findings have theoretical implications, suggesting common signaling pathways in early lymphocytes that are distinct from those employed by more mature cells, and are also of practical interest, to be considered in the design of DSG treatment protocols.</jats:p> The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. The Journal of experimental medicine |
| spellingShingle | Wang, B, Benoist, C, Mathis, D, The Journal of experimental medicine, The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation., Immunology, Immunology and Allergy |
| title | The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_full | The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_fullStr | The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_full_unstemmed | The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_short | The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| title_sort | the immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between pret and preb cell differentiation. |
| title_unstemmed | The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1084/jem.183.6.2427 |