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CD30-mediated signaling promotes the development of human T helper type 2-like T cells.
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| Zeitschriftentitel: | The Journal of experimental medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | The Journal of experimental medicine, 182, 1995, 6, S. 1655-1661 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
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| Schlagwörter: |
| author_facet |
Del Prete, G De Carli, M D'Elios, M M Daniel, K C Almerigogna, F Alderson, M Smith, C A Thomas, E Romagnani, S Del Prete, G De Carli, M D'Elios, M M Daniel, K C Almerigogna, F Alderson, M Smith, C A Thomas, E Romagnani, S |
|---|---|
| author |
Del Prete, G De Carli, M D'Elios, M M Daniel, K C Almerigogna, F Alderson, M Smith, C A Thomas, E Romagnani, S |
| spellingShingle |
Del Prete, G De Carli, M D'Elios, M M Daniel, K C Almerigogna, F Alderson, M Smith, C A Thomas, E Romagnani, S The Journal of experimental medicine CD30-mediated signaling promotes the development of human T helper type 2-like T cells. Immunology Immunology and Allergy |
| author_sort |
del prete, g |
| spelling |
Del Prete, G De Carli, M D'Elios, M M Daniel, K C Almerigogna, F Alderson, M Smith, C A Thomas, E Romagnani, S 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.182.6.1655 <jats:p>We have recently shown that CD30, a member of the tumor necrosis factor/nerve growth factor receptor superfamily, is preferentially expressed by human T cell clones producing T helper (Th) type 2 cytokines. We report here that costimulation with an agonistic anti-CD30 monoclonal antibody enhanced antigen (Ag)-induced proliferation and cytokine secretion by established human Th2 and Th0 clones. Moreover, costimulation of peripheral blood mononuclear cells with the same anti-CD30 monoclonal antibody resulted in the preferential development of Ag-specific T cell lines and clones showing a Th2-like profile of cytokine secretion. In contrast, early blockade in bulk culture of CD30 ligand-CD30 interaction shifted the development of Ag-specific T cells towards the opposite (Th1-like) phenotype. Taken together, these data suggest that CD30 triggering of activated Th cells by CD30 ligand-expressing Ag-presenting cells may represent an important costimulatory signaling for the development of Th2-type responses.</jats:p> CD30-mediated signaling promotes the development of human T helper type 2-like T cells. The Journal of experimental medicine |
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Rockefeller University Press, 1995 |
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The Journal of experimental medicine |
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| title |
CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_unstemmed |
CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_full |
CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_fullStr |
CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_full_unstemmed |
CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_short |
CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_sort |
cd30-mediated signaling promotes the development of human t helper type 2-like t cells. |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1084/jem.182.6.1655 |
| publishDate |
1995 |
| physical |
1655-1661 |
| description |
<jats:p>We have recently shown that CD30, a member of the tumor necrosis factor/nerve growth factor receptor superfamily, is preferentially expressed by human T cell clones producing T helper (Th) type 2 cytokines. We report here that costimulation with an agonistic anti-CD30 monoclonal antibody enhanced antigen (Ag)-induced proliferation and cytokine secretion by established human Th2 and Th0 clones. Moreover, costimulation of peripheral blood mononuclear cells with the same anti-CD30 monoclonal antibody resulted in the preferential development of Ag-specific T cell lines and clones showing a Th2-like profile of cytokine secretion. In contrast, early blockade in bulk culture of CD30 ligand-CD30 interaction shifted the development of Ag-specific T cells towards the opposite (Th1-like) phenotype. Taken together, these data suggest that CD30 triggering of activated Th cells by CD30 ligand-expressing Ag-presenting cells may represent an important costimulatory signaling for the development of Th2-type responses.</jats:p> |
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| author | Del Prete, G, De Carli, M, D'Elios, M M, Daniel, K C, Almerigogna, F, Alderson, M, Smith, C A, Thomas, E, Romagnani, S |
| author_facet | Del Prete, G, De Carli, M, D'Elios, M M, Daniel, K C, Almerigogna, F, Alderson, M, Smith, C A, Thomas, E, Romagnani, S, Del Prete, G, De Carli, M, D'Elios, M M, Daniel, K C, Almerigogna, F, Alderson, M, Smith, C A, Thomas, E, Romagnani, S |
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| description | <jats:p>We have recently shown that CD30, a member of the tumor necrosis factor/nerve growth factor receptor superfamily, is preferentially expressed by human T cell clones producing T helper (Th) type 2 cytokines. We report here that costimulation with an agonistic anti-CD30 monoclonal antibody enhanced antigen (Ag)-induced proliferation and cytokine secretion by established human Th2 and Th0 clones. Moreover, costimulation of peripheral blood mononuclear cells with the same anti-CD30 monoclonal antibody resulted in the preferential development of Ag-specific T cell lines and clones showing a Th2-like profile of cytokine secretion. In contrast, early blockade in bulk culture of CD30 ligand-CD30 interaction shifted the development of Ag-specific T cells towards the opposite (Th1-like) phenotype. Taken together, these data suggest that CD30 triggering of activated Th cells by CD30 ligand-expressing Ag-presenting cells may represent an important costimulatory signaling for the development of Th2-type responses.</jats:p> |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMTgyLjYuMTY1NQ |
| imprint | Rockefeller University Press, 1995 |
| imprint_str_mv | Rockefeller University Press, 1995 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| series | The Journal of experimental medicine |
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| spelling | Del Prete, G De Carli, M D'Elios, M M Daniel, K C Almerigogna, F Alderson, M Smith, C A Thomas, E Romagnani, S 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.182.6.1655 <jats:p>We have recently shown that CD30, a member of the tumor necrosis factor/nerve growth factor receptor superfamily, is preferentially expressed by human T cell clones producing T helper (Th) type 2 cytokines. We report here that costimulation with an agonistic anti-CD30 monoclonal antibody enhanced antigen (Ag)-induced proliferation and cytokine secretion by established human Th2 and Th0 clones. Moreover, costimulation of peripheral blood mononuclear cells with the same anti-CD30 monoclonal antibody resulted in the preferential development of Ag-specific T cell lines and clones showing a Th2-like profile of cytokine secretion. In contrast, early blockade in bulk culture of CD30 ligand-CD30 interaction shifted the development of Ag-specific T cells towards the opposite (Th1-like) phenotype. Taken together, these data suggest that CD30 triggering of activated Th cells by CD30 ligand-expressing Ag-presenting cells may represent an important costimulatory signaling for the development of Th2-type responses.</jats:p> CD30-mediated signaling promotes the development of human T helper type 2-like T cells. The Journal of experimental medicine |
| spellingShingle | Del Prete, G, De Carli, M, D'Elios, M M, Daniel, K C, Almerigogna, F, Alderson, M, Smith, C A, Thomas, E, Romagnani, S, The Journal of experimental medicine, CD30-mediated signaling promotes the development of human T helper type 2-like T cells., Immunology, Immunology and Allergy |
| title | CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_full | CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_fullStr | CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_full_unstemmed | CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_short | CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| title_sort | cd30-mediated signaling promotes the development of human t helper type 2-like t cells. |
| title_unstemmed | CD30-mediated signaling promotes the development of human T helper type 2-like T cells. |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1084/jem.182.6.1655 |