Eintrag weiter verarbeiten
Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity.
Gespeichert in:
Zeitschriftentitel: | The Journal of experimental medicine |
---|---|
Personen und Körperschaften: | , , , |
In: | The Journal of experimental medicine, 174, 1991, 4, S. 809-813 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Rockefeller University Press
|
Schlagwörter: |
author_facet |
Del Prete, G F De Carli, M Ricci, M Romagnani, S Del Prete, G F De Carli, M Ricci, M Romagnani, S |
---|---|
author |
Del Prete, G F De Carli, M Ricci, M Romagnani, S |
spellingShingle |
Del Prete, G F De Carli, M Ricci, M Romagnani, S The Journal of experimental medicine Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. Immunology Immunology and Allergy |
author_sort |
del prete, g f |
spelling |
Del Prete, G F De Carli, M Ricci, M Romagnani, S 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.174.4.809 <jats:p>A large number of CD4+ human T helper type 1 (Th1) clones specific for purified protein derivative and of Th2 clones specific for the excretory/secretory antigen of Toxocara canis, derived from the same individuals, were analyzed for both cytotoxic capacity and helper function for immunoglobulin (Ig) synthesis. The great majority of Th1, but only a minority of Th2 clones exhibited cytolytic activity. All Th2 (noncytolytic) clones induced IgM, IgG, IgA, and IgE synthesis by autologous B cells in the presence of the specific antigen, and the degree of response was proportional to the number of Th2 cells added to B cells. Under the same experimental conditions, Th1 (cytolytic) clones provided helper function for IgM, IgG, and IgA, but not IgE, synthesis with a peak response at 1:1 T/B cell ratio. At higher T/B cell ratios, a strong decrease of Ig synthesis was observed. All Th1 clones lysed Epstein-Barr virus transformed autologous B cells pulsed with the specific antigen. The decrease of Ig production at high T/B cell ratios correlated with the lytic activity of Th1 clones against autologous antigen-presenting B cell targets. These data suggest that Th1 differ from Th2 human T cell clones not only for their profile of cytokine secretion, but also for cytolytic potential and mode of help for B cell Ig synthesis.</jats:p> Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. The Journal of experimental medicine |
doi_str_mv |
10.1084/jem.174.4.809 |
facet_avail |
Online Free |
finc_class_facet |
Medizin |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMTc0LjQuODA5 |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMTc0LjQuODA5 |
institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
imprint |
Rockefeller University Press, 1991 |
imprint_str_mv |
Rockefeller University Press, 1991 |
issn |
0022-1007 1540-9538 |
issn_str_mv |
0022-1007 1540-9538 |
language |
English |
mega_collection |
Rockefeller University Press (CrossRef) |
match_str |
delprete1991helperactivityforimmunoglobulinsynthesisofthelpertype1th1andth2humantcellclonesthehelpofth1clonesislimitedbytheircytolyticcapacity |
publishDateSort |
1991 |
publisher |
Rockefeller University Press |
recordtype |
ai |
record_format |
ai |
series |
The Journal of experimental medicine |
source_id |
49 |
title |
Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_unstemmed |
Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_full |
Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_fullStr |
Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_full_unstemmed |
Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_short |
Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_sort |
helper activity for immunoglobulin synthesis of t helper type 1 (th1) and th2 human t cell clones: the help of th1 clones is limited by their cytolytic capacity. |
topic |
Immunology Immunology and Allergy |
url |
http://dx.doi.org/10.1084/jem.174.4.809 |
publishDate |
1991 |
physical |
809-813 |
description |
<jats:p>A large number of CD4+ human T helper type 1 (Th1) clones specific for purified protein derivative and of Th2 clones specific for the excretory/secretory antigen of Toxocara canis, derived from the same individuals, were analyzed for both cytotoxic capacity and helper function for immunoglobulin (Ig) synthesis. The great majority of Th1, but only a minority of Th2 clones exhibited cytolytic activity. All Th2 (noncytolytic) clones induced IgM, IgG, IgA, and IgE synthesis by autologous B cells in the presence of the specific antigen, and the degree of response was proportional to the number of Th2 cells added to B cells. Under the same experimental conditions, Th1 (cytolytic) clones provided helper function for IgM, IgG, and IgA, but not IgE, synthesis with a peak response at 1:1 T/B cell ratio. At higher T/B cell ratios, a strong decrease of Ig synthesis was observed. All Th1 clones lysed Epstein-Barr virus transformed autologous B cells pulsed with the specific antigen. The decrease of Ig production at high T/B cell ratios correlated with the lytic activity of Th1 clones against autologous antigen-presenting B cell targets. These data suggest that Th1 differ from Th2 human T cell clones not only for their profile of cytokine secretion, but also for cytolytic potential and mode of help for B cell Ig synthesis.</jats:p> |
container_issue |
4 |
container_start_page |
809 |
container_title |
The Journal of experimental medicine |
container_volume |
174 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792342847779766277 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T16:42:19.314Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Helper+activity+for+immunoglobulin+synthesis+of+T+helper+type+1+%28Th1%29+and+Th2+human+T+cell+clones%3A+the+help+of+Th1+clones+is+limited+by+their+cytolytic+capacity.&rft.date=1991-10-01&genre=article&issn=1540-9538&volume=174&issue=4&spage=809&epage=813&pages=809-813&jtitle=The+Journal+of+experimental+medicine&atitle=Helper+activity+for+immunoglobulin+synthesis+of+T+helper+type+1+%28Th1%29+and+Th2+human+T+cell+clones%3A+the+help+of+Th1+clones+is+limited+by+their+cytolytic+capacity.&aulast=Romagnani&aufirst=S&rft_id=info%3Adoi%2F10.1084%2Fjem.174.4.809&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792342847779766277 |
author | Del Prete, G F, De Carli, M, Ricci, M, Romagnani, S |
author_facet | Del Prete, G F, De Carli, M, Ricci, M, Romagnani, S, Del Prete, G F, De Carli, M, Ricci, M, Romagnani, S |
author_sort | del prete, g f |
container_issue | 4 |
container_start_page | 809 |
container_title | The Journal of experimental medicine |
container_volume | 174 |
description | <jats:p>A large number of CD4+ human T helper type 1 (Th1) clones specific for purified protein derivative and of Th2 clones specific for the excretory/secretory antigen of Toxocara canis, derived from the same individuals, were analyzed for both cytotoxic capacity and helper function for immunoglobulin (Ig) synthesis. The great majority of Th1, but only a minority of Th2 clones exhibited cytolytic activity. All Th2 (noncytolytic) clones induced IgM, IgG, IgA, and IgE synthesis by autologous B cells in the presence of the specific antigen, and the degree of response was proportional to the number of Th2 cells added to B cells. Under the same experimental conditions, Th1 (cytolytic) clones provided helper function for IgM, IgG, and IgA, but not IgE, synthesis with a peak response at 1:1 T/B cell ratio. At higher T/B cell ratios, a strong decrease of Ig synthesis was observed. All Th1 clones lysed Epstein-Barr virus transformed autologous B cells pulsed with the specific antigen. The decrease of Ig production at high T/B cell ratios correlated with the lytic activity of Th1 clones against autologous antigen-presenting B cell targets. These data suggest that Th1 differ from Th2 human T cell clones not only for their profile of cytokine secretion, but also for cytolytic potential and mode of help for B cell Ig synthesis.</jats:p> |
doi_str_mv | 10.1084/jem.174.4.809 |
facet_avail | Online, Free |
finc_class_facet | Medizin |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA4NC9qZW0uMTc0LjQuODA5 |
imprint | Rockefeller University Press, 1991 |
imprint_str_mv | Rockefeller University Press, 1991 |
institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
issn | 0022-1007, 1540-9538 |
issn_str_mv | 0022-1007, 1540-9538 |
language | English |
last_indexed | 2024-03-01T16:42:19.314Z |
match_str | delprete1991helperactivityforimmunoglobulinsynthesisofthelpertype1th1andth2humantcellclonesthehelpofth1clonesislimitedbytheircytolyticcapacity |
mega_collection | Rockefeller University Press (CrossRef) |
physical | 809-813 |
publishDate | 1991 |
publishDateSort | 1991 |
publisher | Rockefeller University Press |
record_format | ai |
recordtype | ai |
series | The Journal of experimental medicine |
source_id | 49 |
spelling | Del Prete, G F De Carli, M Ricci, M Romagnani, S 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.174.4.809 <jats:p>A large number of CD4+ human T helper type 1 (Th1) clones specific for purified protein derivative and of Th2 clones specific for the excretory/secretory antigen of Toxocara canis, derived from the same individuals, were analyzed for both cytotoxic capacity and helper function for immunoglobulin (Ig) synthesis. The great majority of Th1, but only a minority of Th2 clones exhibited cytolytic activity. All Th2 (noncytolytic) clones induced IgM, IgG, IgA, and IgE synthesis by autologous B cells in the presence of the specific antigen, and the degree of response was proportional to the number of Th2 cells added to B cells. Under the same experimental conditions, Th1 (cytolytic) clones provided helper function for IgM, IgG, and IgA, but not IgE, synthesis with a peak response at 1:1 T/B cell ratio. At higher T/B cell ratios, a strong decrease of Ig synthesis was observed. All Th1 clones lysed Epstein-Barr virus transformed autologous B cells pulsed with the specific antigen. The decrease of Ig production at high T/B cell ratios correlated with the lytic activity of Th1 clones against autologous antigen-presenting B cell targets. These data suggest that Th1 differ from Th2 human T cell clones not only for their profile of cytokine secretion, but also for cytolytic potential and mode of help for B cell Ig synthesis.</jats:p> Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. The Journal of experimental medicine |
spellingShingle | Del Prete, G F, De Carli, M, Ricci, M, Romagnani, S, The Journal of experimental medicine, Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity., Immunology, Immunology and Allergy |
title | Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_full | Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_fullStr | Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_full_unstemmed | Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_short | Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
title_sort | helper activity for immunoglobulin synthesis of t helper type 1 (th1) and th2 human t cell clones: the help of th1 clones is limited by their cytolytic capacity. |
title_unstemmed | Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. |
topic | Immunology, Immunology and Allergy |
url | http://dx.doi.org/10.1084/jem.174.4.809 |