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Influence of Fv-1 alleles on cellular expression of gp70.
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| Zeitschriftentitel: | The Journal of experimental medicine |
|---|---|
| Personen und Körperschaften: | , , |
| In: | The Journal of experimental medicine, 151, 1980, 4, S. 980-983 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
|
| Schlagwörter: |
| author_facet |
Tung, J S Boyse, E A Shen, F W Tung, J S Boyse, E A Shen, F W |
|---|---|
| author |
Tung, J S Boyse, E A Shen, F W |
| spellingShingle |
Tung, J S Boyse, E A Shen, F W The Journal of experimental medicine Influence of Fv-1 alleles on cellular expression of gp70. Immunology Immunology and Allergy |
| author_sort |
tung, j s |
| spelling |
Tung, J S Boyse, E A Shen, F W 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.151.4.980 <jats:p>Type-variants of gp70 (glycoprotein-70), which is the major envelope protein of C-type mouse virus and is also found in plasma membranes, are identified immunogenetically by the antigens Gix and Ec. Cellular expression of Gix+ gp70 does not depend on production of virus, but expression of Ec+ gp70 (formerly X-gp70) has been observed only in AKR and other strains of mice that produce large amounts of virus throughout life. To test the inference that cellular expression of Ec+ gp70 is secondary to production of virus we examined the effect of Fv-1 alleles, which govern the replicability of N-tropic and B-tropic C-type virus, on the expression of Ec+ gp70 on thymocytes. By typing thymocytes of Fv-1-congenic mice for Ec+ gp70 was found that manifestation of the Ec+ gp70 phenotype requires the Fv-1n allele, which is permissive for replication of N-tropic virus produced by AKR and other virus-producing mouse strains. Substitution of the Fv-1b allele for the Fv-1n allele abolishes demonstrable expression of Ec+ gp70 by AKR thymocytes at ages up to 9 mo, the oldest AKR mice tested.</jats:p> Influence of Fv-1 alleles on cellular expression of gp70. The Journal of experimental medicine |
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| title |
Influence of Fv-1 alleles on cellular expression of gp70. |
| title_unstemmed |
Influence of Fv-1 alleles on cellular expression of gp70. |
| title_full |
Influence of Fv-1 alleles on cellular expression of gp70. |
| title_fullStr |
Influence of Fv-1 alleles on cellular expression of gp70. |
| title_full_unstemmed |
Influence of Fv-1 alleles on cellular expression of gp70. |
| title_short |
Influence of Fv-1 alleles on cellular expression of gp70. |
| title_sort |
influence of fv-1 alleles on cellular expression of gp70. |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1084/jem.151.4.980 |
| publishDate |
1980 |
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980-983 |
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<jats:p>Type-variants of gp70 (glycoprotein-70), which is the major envelope protein of C-type mouse virus and is also found in plasma membranes, are identified immunogenetically by the antigens Gix and Ec. Cellular expression of Gix+ gp70 does not depend on production of virus, but expression of Ec+ gp70 (formerly X-gp70) has been observed only in AKR and other strains of mice that produce large amounts of virus throughout life. To test the inference that cellular expression of Ec+ gp70 is secondary to production of virus we examined the effect of Fv-1 alleles, which govern the replicability of N-tropic and B-tropic C-type virus, on the expression of Ec+ gp70 on thymocytes. By typing thymocytes of Fv-1-congenic mice for Ec+ gp70 was found that manifestation of the Ec+ gp70 phenotype requires the Fv-1n allele, which is permissive for replication of N-tropic virus produced by AKR and other virus-producing mouse strains. Substitution of the Fv-1b allele for the Fv-1n allele abolishes demonstrable expression of Ec+ gp70 by AKR thymocytes at ages up to 9 mo, the oldest AKR mice tested.</jats:p> |
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| description | <jats:p>Type-variants of gp70 (glycoprotein-70), which is the major envelope protein of C-type mouse virus and is also found in plasma membranes, are identified immunogenetically by the antigens Gix and Ec. Cellular expression of Gix+ gp70 does not depend on production of virus, but expression of Ec+ gp70 (formerly X-gp70) has been observed only in AKR and other strains of mice that produce large amounts of virus throughout life. To test the inference that cellular expression of Ec+ gp70 is secondary to production of virus we examined the effect of Fv-1 alleles, which govern the replicability of N-tropic and B-tropic C-type virus, on the expression of Ec+ gp70 on thymocytes. By typing thymocytes of Fv-1-congenic mice for Ec+ gp70 was found that manifestation of the Ec+ gp70 phenotype requires the Fv-1n allele, which is permissive for replication of N-tropic virus produced by AKR and other virus-producing mouse strains. Substitution of the Fv-1b allele for the Fv-1n allele abolishes demonstrable expression of Ec+ gp70 by AKR thymocytes at ages up to 9 mo, the oldest AKR mice tested.</jats:p> |
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| spelling | Tung, J S Boyse, E A Shen, F W 0022-1007 1540-9538 Rockefeller University Press Immunology Immunology and Allergy http://dx.doi.org/10.1084/jem.151.4.980 <jats:p>Type-variants of gp70 (glycoprotein-70), which is the major envelope protein of C-type mouse virus and is also found in plasma membranes, are identified immunogenetically by the antigens Gix and Ec. Cellular expression of Gix+ gp70 does not depend on production of virus, but expression of Ec+ gp70 (formerly X-gp70) has been observed only in AKR and other strains of mice that produce large amounts of virus throughout life. To test the inference that cellular expression of Ec+ gp70 is secondary to production of virus we examined the effect of Fv-1 alleles, which govern the replicability of N-tropic and B-tropic C-type virus, on the expression of Ec+ gp70 on thymocytes. By typing thymocytes of Fv-1-congenic mice for Ec+ gp70 was found that manifestation of the Ec+ gp70 phenotype requires the Fv-1n allele, which is permissive for replication of N-tropic virus produced by AKR and other virus-producing mouse strains. Substitution of the Fv-1b allele for the Fv-1n allele abolishes demonstrable expression of Ec+ gp70 by AKR thymocytes at ages up to 9 mo, the oldest AKR mice tested.</jats:p> Influence of Fv-1 alleles on cellular expression of gp70. The Journal of experimental medicine |
| spellingShingle | Tung, J S, Boyse, E A, Shen, F W, The Journal of experimental medicine, Influence of Fv-1 alleles on cellular expression of gp70., Immunology, Immunology and Allergy |
| title | Influence of Fv-1 alleles on cellular expression of gp70. |
| title_full | Influence of Fv-1 alleles on cellular expression of gp70. |
| title_fullStr | Influence of Fv-1 alleles on cellular expression of gp70. |
| title_full_unstemmed | Influence of Fv-1 alleles on cellular expression of gp70. |
| title_short | Influence of Fv-1 alleles on cellular expression of gp70. |
| title_sort | influence of fv-1 alleles on cellular expression of gp70. |
| title_unstemmed | Influence of Fv-1 alleles on cellular expression of gp70. |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1084/jem.151.4.980 |