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THE DIFFERENTIATION PATHWAY OF T LYMPHOCYTES
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| Zeitschriftentitel: | The Journal of Experimental Medicine |
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| Personen und Körperschaften: | |
| In: | The Journal of Experimental Medicine, 140, 1974, 2, S. 566-577 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Rockefeller University Press
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| Schlagwörter: |
| Zusammenfassung: | <jats:p>Two experimental models have been used to study T-cell differentiation. The first, a graft-vs.-host reaction, was induced by injecting thymocytes or cortisone-resistant thymocytes into lethally irradiated allogeneic mice. The second was tumor graft rejection in allogeneic hosts. Ultrastructural studies at various time intervals revealed two differentiated T-cell types. One of these (the "pale" cell) is probably high cytotoxic as measured in the chromium-release assay, the other (the "dark" cell) may be an "amplifier" cell, helping in the differentiation of cytotoxic cells.</jats:p> |
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| Umfang: | 566-577 |
| ISSN: |
1540-9538
0022-1007 |
| DOI: | 10.1084/jem.140.2.566 |