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Design of artificial sequence-specific DNA bending ligands.
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , |
| In: | Proceedings of the National Academy of Sciences, 93, 1996, 18, S. 9510-9514 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Liberles, D A Dervan, P B Liberles, D A Dervan, P B |
|---|---|
| author |
Liberles, D A Dervan, P B |
| spellingShingle |
Liberles, D A Dervan, P B Proceedings of the National Academy of Sciences Design of artificial sequence-specific DNA bending ligands. Multidisciplinary |
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liberles, d a |
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Liberles, D A Dervan, P B 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.93.18.9510 <jats:p>Proteins that bend DNA are important regulators of biological processes. Sequence-specific DNA bending ligands have been designed that bind two noncontiguous sites in the major groove and induce a bend in the DNA. An oligonucleotide containing pyrimidine segments separated by a central variable linker domain simultaneously binds by triple helix formation two 15-bp purine tracts separated by 10 bp. Bend angles of 61 degrees, 50 degrees, and 38 degrees directed towards the minor groove were quantitated by phasing analysis for linkers of four, five, and six T residues, respectively. The design and synthesis of nonnatural architectural factors may provide a new class of reagents for use in biology and human medicine.</jats:p> Design of artificial sequence-specific DNA bending ligands. Proceedings of the National Academy of Sciences |
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| title |
Design of artificial sequence-specific DNA bending ligands. |
| title_unstemmed |
Design of artificial sequence-specific DNA bending ligands. |
| title_full |
Design of artificial sequence-specific DNA bending ligands. |
| title_fullStr |
Design of artificial sequence-specific DNA bending ligands. |
| title_full_unstemmed |
Design of artificial sequence-specific DNA bending ligands. |
| title_short |
Design of artificial sequence-specific DNA bending ligands. |
| title_sort |
design of artificial sequence-specific dna bending ligands. |
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Multidisciplinary |
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http://dx.doi.org/10.1073/pnas.93.18.9510 |
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1996 |
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9510-9514 |
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<jats:p>Proteins that bend DNA are important regulators of biological processes. Sequence-specific DNA bending ligands have been designed that bind two noncontiguous sites in the major groove and induce a bend in the DNA. An oligonucleotide containing pyrimidine segments separated by a central variable linker domain simultaneously binds by triple helix formation two 15-bp purine tracts separated by 10 bp. Bend angles of 61 degrees, 50 degrees, and 38 degrees directed towards the minor groove were quantitated by phasing analysis for linkers of four, five, and six T residues, respectively. The design and synthesis of nonnatural architectural factors may provide a new class of reagents for use in biology and human medicine.</jats:p> |
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| author | Liberles, D A, Dervan, P B |
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| description | <jats:p>Proteins that bend DNA are important regulators of biological processes. Sequence-specific DNA bending ligands have been designed that bind two noncontiguous sites in the major groove and induce a bend in the DNA. An oligonucleotide containing pyrimidine segments separated by a central variable linker domain simultaneously binds by triple helix formation two 15-bp purine tracts separated by 10 bp. Bend angles of 61 degrees, 50 degrees, and 38 degrees directed towards the minor groove were quantitated by phasing analysis for linkers of four, five, and six T residues, respectively. The design and synthesis of nonnatural architectural factors may provide a new class of reagents for use in biology and human medicine.</jats:p> |
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| imprint | Proceedings of the National Academy of Sciences, 1996 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 1996 |
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| spelling | Liberles, D A Dervan, P B 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.93.18.9510 <jats:p>Proteins that bend DNA are important regulators of biological processes. Sequence-specific DNA bending ligands have been designed that bind two noncontiguous sites in the major groove and induce a bend in the DNA. An oligonucleotide containing pyrimidine segments separated by a central variable linker domain simultaneously binds by triple helix formation two 15-bp purine tracts separated by 10 bp. Bend angles of 61 degrees, 50 degrees, and 38 degrees directed towards the minor groove were quantitated by phasing analysis for linkers of four, five, and six T residues, respectively. The design and synthesis of nonnatural architectural factors may provide a new class of reagents for use in biology and human medicine.</jats:p> Design of artificial sequence-specific DNA bending ligands. Proceedings of the National Academy of Sciences |
| spellingShingle | Liberles, D A, Dervan, P B, Proceedings of the National Academy of Sciences, Design of artificial sequence-specific DNA bending ligands., Multidisciplinary |
| title | Design of artificial sequence-specific DNA bending ligands. |
| title_full | Design of artificial sequence-specific DNA bending ligands. |
| title_fullStr | Design of artificial sequence-specific DNA bending ligands. |
| title_full_unstemmed | Design of artificial sequence-specific DNA bending ligands. |
| title_short | Design of artificial sequence-specific DNA bending ligands. |
| title_sort | design of artificial sequence-specific dna bending ligands. |
| title_unstemmed | Design of artificial sequence-specific DNA bending ligands. |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.93.18.9510 |