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In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Proceedings of the National Academy of Sciences, 96, 1999, 9, S. 5182-5187 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Cagle, Dawson W. Kennel, Stephen J. Mirzadeh, Saed Alford, J. Michael Wilson, Lon J. Cagle, Dawson W. Kennel, Stephen J. Mirzadeh, Saed Alford, J. Michael Wilson, Lon J. |
|---|---|
| author |
Cagle, Dawson W. Kennel, Stephen J. Mirzadeh, Saed Alford, J. Michael Wilson, Lon J. |
| spellingShingle |
Cagle, Dawson W. Kennel, Stephen J. Mirzadeh, Saed Alford, J. Michael Wilson, Lon J. Proceedings of the National Academy of Sciences In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers Multidisciplinary |
| author_sort |
cagle, dawson w. |
| spelling |
Cagle, Dawson W. Kennel, Stephen J. Mirzadeh, Saed Alford, J. Michael Wilson, Lon J. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.96.9.5182 <jats:p> Biodistribution studies of a water-soluble radioactive metallofullerene compound have been conducted using BALB/c mice. To this end, a sample containing Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (x = 1, 2) was purified and derivatized to prepare the water-soluble metallofullerol, Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> . This metallofullerol was then neutron-activated ( <jats:sup>165</jats:sup> Ho[n,γ] <jats:sup>166</jats:sup> Ho) to prepare the <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> analog as a radiotracer, which was monitored, after intravenous administration, for up to 48 hours by using dissection radioanalysis, and its biodistribution was compared with a control compound, Na <jats:sub>2</jats:sub> [ <jats:sup>166</jats:sup> Ho(DTPA)(H <jats:sub>2</jats:sub> O)]. Results showed selective localization of the <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> tracer in the liver but with slow clearance, as well as uptake by bone without clearance. In contrast, excretion of the control compound was nearly quantitative after 1 hour. The fate of <jats:sup>166</jats:sup> Ho was also explored by a metabolism study of <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> in Fischer rats. Results indicated 20% excretion of intact <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> within 5 days. The present findings demonstrate the feasibility of using water-solubilized metallofullerene radiotracers to monitor the fate of fullerene-based materials in animals, and suggest that water-solubilized fullerene materials, in general, may be useful components in drug design. </jats:p> <i>In vivo</i> studies of fullerene-based materials using endohedral metallofullerene radiotracers Proceedings of the National Academy of Sciences |
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Proceedings of the National Academy of Sciences, 1999 |
| imprint_str_mv |
Proceedings of the National Academy of Sciences, 1999 |
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0027-8424 1091-6490 |
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0027-8424 1091-6490 |
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Proceedings of the National Academy of Sciences (CrossRef) |
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cagle1999invivostudiesoffullerenebasedmaterialsusingendohedralmetallofullereneradiotracers |
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1999 |
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Proceedings of the National Academy of Sciences |
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ai |
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ai |
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Proceedings of the National Academy of Sciences |
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49 |
| title |
In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_unstemmed |
In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_full |
In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_fullStr |
In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_full_unstemmed |
In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_short |
In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_sort |
<i>in vivo</i>
studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.96.9.5182 |
| publishDate |
1999 |
| physical |
5182-5187 |
| description |
<jats:p>
Biodistribution studies of a water-soluble radioactive metallofullerene compound have been conducted using BALB/c mice. To this end, a sample containing Ho
<jats:sub>x</jats:sub>
@C
<jats:sub>82</jats:sub>
(x = 1, 2) was purified and derivatized to prepare the water-soluble metallofullerol, Ho
<jats:sub>x</jats:sub>
@C
<jats:sub>82</jats:sub>
(OH)
<jats:sub>y</jats:sub>
. This metallofullerol was then neutron-activated (
<jats:sup>165</jats:sup>
Ho[n,γ]
<jats:sup>166</jats:sup>
Ho) to prepare the
<jats:sup>166</jats:sup>
Ho
<jats:sub>x</jats:sub>
@C
<jats:sub>82</jats:sub>
(OH)
<jats:sub>y</jats:sub>
analog as a radiotracer, which was monitored, after intravenous administration, for up to 48 hours by using dissection radioanalysis, and its biodistribution was compared with a control compound, Na
<jats:sub>2</jats:sub>
[
<jats:sup>166</jats:sup>
Ho(DTPA)(H
<jats:sub>2</jats:sub>
O)]. Results showed selective localization of the
<jats:sup>166</jats:sup>
Ho
<jats:sub>x</jats:sub>
@C
<jats:sub>82</jats:sub>
(OH)
<jats:sub>y</jats:sub>
tracer in the liver but with slow clearance, as well as uptake by bone without clearance. In contrast, excretion of the control compound was nearly quantitative after 1 hour. The fate of
<jats:sup>166</jats:sup>
Ho was also explored by a metabolism study of
<jats:sup>166</jats:sup>
Ho
<jats:sub>x</jats:sub>
@C
<jats:sub>82</jats:sub>
(OH)
<jats:sub>y</jats:sub>
in Fischer rats. Results indicated 20% excretion of intact
<jats:sup>166</jats:sup>
Ho
<jats:sub>x</jats:sub>
@C
<jats:sub>82</jats:sub>
(OH)
<jats:sub>y</jats:sub>
within 5 days. The present findings demonstrate the feasibility of using water-solubilized metallofullerene radiotracers to monitor the fate of fullerene-based materials in animals, and suggest that water-solubilized fullerene materials, in general, may be useful components in drug design.
</jats:p> |
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| author | Cagle, Dawson W., Kennel, Stephen J., Mirzadeh, Saed, Alford, J. Michael, Wilson, Lon J. |
| author_facet | Cagle, Dawson W., Kennel, Stephen J., Mirzadeh, Saed, Alford, J. Michael, Wilson, Lon J., Cagle, Dawson W., Kennel, Stephen J., Mirzadeh, Saed, Alford, J. Michael, Wilson, Lon J. |
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| description | <jats:p> Biodistribution studies of a water-soluble radioactive metallofullerene compound have been conducted using BALB/c mice. To this end, a sample containing Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (x = 1, 2) was purified and derivatized to prepare the water-soluble metallofullerol, Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> . This metallofullerol was then neutron-activated ( <jats:sup>165</jats:sup> Ho[n,γ] <jats:sup>166</jats:sup> Ho) to prepare the <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> analog as a radiotracer, which was monitored, after intravenous administration, for up to 48 hours by using dissection radioanalysis, and its biodistribution was compared with a control compound, Na <jats:sub>2</jats:sub> [ <jats:sup>166</jats:sup> Ho(DTPA)(H <jats:sub>2</jats:sub> O)]. Results showed selective localization of the <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> tracer in the liver but with slow clearance, as well as uptake by bone without clearance. In contrast, excretion of the control compound was nearly quantitative after 1 hour. The fate of <jats:sup>166</jats:sup> Ho was also explored by a metabolism study of <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> in Fischer rats. Results indicated 20% excretion of intact <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> within 5 days. The present findings demonstrate the feasibility of using water-solubilized metallofullerene radiotracers to monitor the fate of fullerene-based materials in animals, and suggest that water-solubilized fullerene materials, in general, may be useful components in drug design. </jats:p> |
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| imprint | Proceedings of the National Academy of Sciences, 1999 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 1999 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 5182-5187 |
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| publishDateSort | 1999 |
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| spelling | Cagle, Dawson W. Kennel, Stephen J. Mirzadeh, Saed Alford, J. Michael Wilson, Lon J. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.96.9.5182 <jats:p> Biodistribution studies of a water-soluble radioactive metallofullerene compound have been conducted using BALB/c mice. To this end, a sample containing Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (x = 1, 2) was purified and derivatized to prepare the water-soluble metallofullerol, Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> . This metallofullerol was then neutron-activated ( <jats:sup>165</jats:sup> Ho[n,γ] <jats:sup>166</jats:sup> Ho) to prepare the <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> analog as a radiotracer, which was monitored, after intravenous administration, for up to 48 hours by using dissection radioanalysis, and its biodistribution was compared with a control compound, Na <jats:sub>2</jats:sub> [ <jats:sup>166</jats:sup> Ho(DTPA)(H <jats:sub>2</jats:sub> O)]. Results showed selective localization of the <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> tracer in the liver but with slow clearance, as well as uptake by bone without clearance. In contrast, excretion of the control compound was nearly quantitative after 1 hour. The fate of <jats:sup>166</jats:sup> Ho was also explored by a metabolism study of <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> in Fischer rats. Results indicated 20% excretion of intact <jats:sup>166</jats:sup> Ho <jats:sub>x</jats:sub> @C <jats:sub>82</jats:sub> (OH) <jats:sub>y</jats:sub> within 5 days. The present findings demonstrate the feasibility of using water-solubilized metallofullerene radiotracers to monitor the fate of fullerene-based materials in animals, and suggest that water-solubilized fullerene materials, in general, may be useful components in drug design. </jats:p> <i>In vivo</i> studies of fullerene-based materials using endohedral metallofullerene radiotracers Proceedings of the National Academy of Sciences |
| spellingShingle | Cagle, Dawson W., Kennel, Stephen J., Mirzadeh, Saed, Alford, J. Michael, Wilson, Lon J., Proceedings of the National Academy of Sciences, In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers, Multidisciplinary |
| title | In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_full | In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_fullStr | In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_full_unstemmed | In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_short | In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_sort | <i>in vivo</i> studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| title_unstemmed | In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.96.9.5182 |