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Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion.
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Proceedings of the National Academy of Sciences, 89, 1992, 20, S. 9739-9743 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| author_facet |
Gelpi, C Sontheimer, E J Rodriguez-Sanchez, J L Gelpi, C Sontheimer, E J Rodriguez-Sanchez, J L |
|---|---|
| author |
Gelpi, C Sontheimer, E J Rodriguez-Sanchez, J L |
| spellingShingle |
Gelpi, C Sontheimer, E J Rodriguez-Sanchez, J L Proceedings of the National Academy of Sciences Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. Multidisciplinary |
| author_sort |
gelpi, c |
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Gelpi, C Sontheimer, E J Rodriguez-Sanchez, J L 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.89.20.9739 <jats:p>We describe an autoantibody specificity present in a subgroup of patients with a severe form of autoimmune chronic active hepatitis. These antibodies precipitate a 90-nucleotide RNA from human whole cell extracts and recognize a 48-kDa polypeptide in immunoblotting assays. The RNA is a UGA suppressor serine tRNA that carries selenocysteine (tRNA[Ser]Sec)), as shown by sequence analysis. The protein does not appear to be seryl-tRNA synthetase; rather, it is an excellent candidate for a factor involved in cotranslational selenocysteine incorporation in human cells.</jats:p> Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. Proceedings of the National Academy of Sciences |
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| title |
Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_unstemmed |
Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_full |
Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_fullStr |
Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_full_unstemmed |
Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_short |
Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_sort |
autoantibodies against a serine trna-protein complex implicated in cotranslational selenocysteine insertion. |
| topic |
Multidisciplinary |
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http://dx.doi.org/10.1073/pnas.89.20.9739 |
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1992 |
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9739-9743 |
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<jats:p>We describe an autoantibody specificity present in a subgroup of patients with a severe form of autoimmune chronic active hepatitis. These antibodies precipitate a 90-nucleotide RNA from human whole cell extracts and recognize a 48-kDa polypeptide in immunoblotting assays. The RNA is a UGA suppressor serine tRNA that carries selenocysteine (tRNA[Ser]Sec)), as shown by sequence analysis. The protein does not appear to be seryl-tRNA synthetase; rather, it is an excellent candidate for a factor involved in cotranslational selenocysteine incorporation in human cells.</jats:p> |
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| author | Gelpi, C, Sontheimer, E J, Rodriguez-Sanchez, J L |
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| description | <jats:p>We describe an autoantibody specificity present in a subgroup of patients with a severe form of autoimmune chronic active hepatitis. These antibodies precipitate a 90-nucleotide RNA from human whole cell extracts and recognize a 48-kDa polypeptide in immunoblotting assays. The RNA is a UGA suppressor serine tRNA that carries selenocysteine (tRNA[Ser]Sec)), as shown by sequence analysis. The protein does not appear to be seryl-tRNA synthetase; rather, it is an excellent candidate for a factor involved in cotranslational selenocysteine incorporation in human cells.</jats:p> |
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| imprint | Proceedings of the National Academy of Sciences, 1992 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 1992 |
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| spelling | Gelpi, C Sontheimer, E J Rodriguez-Sanchez, J L 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.89.20.9739 <jats:p>We describe an autoantibody specificity present in a subgroup of patients with a severe form of autoimmune chronic active hepatitis. These antibodies precipitate a 90-nucleotide RNA from human whole cell extracts and recognize a 48-kDa polypeptide in immunoblotting assays. The RNA is a UGA suppressor serine tRNA that carries selenocysteine (tRNA[Ser]Sec)), as shown by sequence analysis. The protein does not appear to be seryl-tRNA synthetase; rather, it is an excellent candidate for a factor involved in cotranslational selenocysteine incorporation in human cells.</jats:p> Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. Proceedings of the National Academy of Sciences |
| spellingShingle | Gelpi, C, Sontheimer, E J, Rodriguez-Sanchez, J L, Proceedings of the National Academy of Sciences, Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion., Multidisciplinary |
| title | Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_full | Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_fullStr | Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_full_unstemmed | Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_short | Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| title_sort | autoantibodies against a serine trna-protein complex implicated in cotranslational selenocysteine insertion. |
| title_unstemmed | Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.89.20.9739 |