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Caspase-10 is an initiator caspase in death receptor signaling
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Proceedings of the National Academy of Sciences, 98, 2001, 24, S. 13884-13888 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Wang, Jin Chun, Hyung J. Wong, Wilson Spencer, David M. Lenardo, Michael J. Wang, Jin Chun, Hyung J. Wong, Wilson Spencer, David M. Lenardo, Michael J. |
|---|---|
| author |
Wang, Jin Chun, Hyung J. Wong, Wilson Spencer, David M. Lenardo, Michael J. |
| spellingShingle |
Wang, Jin Chun, Hyung J. Wong, Wilson Spencer, David M. Lenardo, Michael J. Proceedings of the National Academy of Sciences Caspase-10 is an initiator caspase in death receptor signaling Multidisciplinary |
| author_sort |
wang, jin |
| spelling |
Wang, Jin Chun, Hyung J. Wong, Wilson Spencer, David M. Lenardo, Michael J. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.241358198 <jats:p>A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-receptor-mediated apoptosis. Moreover, Fas crosslinking in primary human T cells leads to the recruitment and activation of caspase-10. Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of FADD. Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially distinct roles in death receptor signaling or other cellular processes.</jats:p> Caspase-10 is an initiator caspase in death receptor signaling Proceedings of the National Academy of Sciences |
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Proceedings of the National Academy of Sciences, 2001 |
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2001 |
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Proceedings of the National Academy of Sciences |
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| title |
Caspase-10 is an initiator caspase in death receptor signaling |
| title_unstemmed |
Caspase-10 is an initiator caspase in death receptor signaling |
| title_full |
Caspase-10 is an initiator caspase in death receptor signaling |
| title_fullStr |
Caspase-10 is an initiator caspase in death receptor signaling |
| title_full_unstemmed |
Caspase-10 is an initiator caspase in death receptor signaling |
| title_short |
Caspase-10 is an initiator caspase in death receptor signaling |
| title_sort |
caspase-10 is an initiator caspase in death receptor signaling |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.241358198 |
| publishDate |
2001 |
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13884-13888 |
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<jats:p>A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-receptor-mediated apoptosis. Moreover, Fas crosslinking in primary human T cells leads to the recruitment and activation of caspase-10. Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of FADD. Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially distinct roles in death receptor signaling or other cellular processes.</jats:p> |
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| author | Wang, Jin, Chun, Hyung J., Wong, Wilson, Spencer, David M., Lenardo, Michael J. |
| author_facet | Wang, Jin, Chun, Hyung J., Wong, Wilson, Spencer, David M., Lenardo, Michael J., Wang, Jin, Chun, Hyung J., Wong, Wilson, Spencer, David M., Lenardo, Michael J. |
| author_sort | wang, jin |
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| container_title | Proceedings of the National Academy of Sciences |
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| description | <jats:p>A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-receptor-mediated apoptosis. Moreover, Fas crosslinking in primary human T cells leads to the recruitment and activation of caspase-10. Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of FADD. Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially distinct roles in death receptor signaling or other cellular processes.</jats:p> |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjI0MTM1ODE5OA |
| imprint | Proceedings of the National Academy of Sciences, 2001 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 2001 |
| institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
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| physical | 13884-13888 |
| publishDate | 2001 |
| publishDateSort | 2001 |
| publisher | Proceedings of the National Academy of Sciences |
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| recordtype | ai |
| series | Proceedings of the National Academy of Sciences |
| source_id | 49 |
| spelling | Wang, Jin Chun, Hyung J. Wong, Wilson Spencer, David M. Lenardo, Michael J. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.241358198 <jats:p>A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-receptor-mediated apoptosis. Moreover, Fas crosslinking in primary human T cells leads to the recruitment and activation of caspase-10. Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of FADD. Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially distinct roles in death receptor signaling or other cellular processes.</jats:p> Caspase-10 is an initiator caspase in death receptor signaling Proceedings of the National Academy of Sciences |
| spellingShingle | Wang, Jin, Chun, Hyung J., Wong, Wilson, Spencer, David M., Lenardo, Michael J., Proceedings of the National Academy of Sciences, Caspase-10 is an initiator caspase in death receptor signaling, Multidisciplinary |
| title | Caspase-10 is an initiator caspase in death receptor signaling |
| title_full | Caspase-10 is an initiator caspase in death receptor signaling |
| title_fullStr | Caspase-10 is an initiator caspase in death receptor signaling |
| title_full_unstemmed | Caspase-10 is an initiator caspase in death receptor signaling |
| title_short | Caspase-10 is an initiator caspase in death receptor signaling |
| title_sort | caspase-10 is an initiator caspase in death receptor signaling |
| title_unstemmed | Caspase-10 is an initiator caspase in death receptor signaling |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.241358198 |