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Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi
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Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
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Personen und Körperschaften: | , , , , , , , , |
In: | Proceedings of the National Academy of Sciences, 111, 2014, 17, S. 6419-6424 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Proceedings of the National Academy of Sciences
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Schlagwörter: |
author_facet |
Zhuang, Wei-Qin Yi, Shan Bill, Markus Brisson, Vanessa L. Feng, Xueyang Men, Yujie Conrad, Mark E. Tang, Yinjie J. Alvarez-Cohen, Lisa Zhuang, Wei-Qin Yi, Shan Bill, Markus Brisson, Vanessa L. Feng, Xueyang Men, Yujie Conrad, Mark E. Tang, Yinjie J. Alvarez-Cohen, Lisa |
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author |
Zhuang, Wei-Qin Yi, Shan Bill, Markus Brisson, Vanessa L. Feng, Xueyang Men, Yujie Conrad, Mark E. Tang, Yinjie J. Alvarez-Cohen, Lisa |
spellingShingle |
Zhuang, Wei-Qin Yi, Shan Bill, Markus Brisson, Vanessa L. Feng, Xueyang Men, Yujie Conrad, Mark E. Tang, Yinjie J. Alvarez-Cohen, Lisa Proceedings of the National Academy of Sciences Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi Multidisciplinary |
author_sort |
zhuang, wei-qin |
spelling |
Zhuang, Wei-Qin Yi, Shan Bill, Markus Brisson, Vanessa L. Feng, Xueyang Men, Yujie Conrad, Mark E. Tang, Yinjie J. Alvarez-Cohen, Lisa 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1321542111 <jats:title>Significance</jats:title> <jats:p> We have studied the functionality of an incomplete acetyl-CoA “Wood–Ljungdahl” pathway in a strictly organohalide-respiring bacterium, <jats:italic>Dehalococcoides mccartyi</jats:italic> . We found that in addition to its ability to incorporate exogenous formate, this pathway cleaves acetyl-CoA to generate methyl-tetrahydrofolate for methionine biosynthesis, serving as a unique substitute of the missing methylene-tetrahydrofolate reductase function. We also found that accumulation of carbon monoxide (CO), an obligate by-product from acetyl-CoA cleavage, inhibits <jats:italic>D. mccartyi</jats:italic> axenic cultures, but can be ameliorated by the presence of a CO-oxidizing organism, resulting in an unusual syntrophic association. The understanding of the products and biosynthetic functions of this incomplete Wood–Ljungdahl pathway improves our knowledge of alternate central metabolic strategies used by environmental microorganisms. </jats:p> Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring <i>Dehalococcoides mccartyi</i> Proceedings of the National Academy of Sciences |
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10.1073/pnas.1321542111 |
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title |
Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_unstemmed |
Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_full |
Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_fullStr |
Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_full_unstemmed |
Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_short |
Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_sort |
incomplete wood–ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring
<i>dehalococcoides mccartyi</i> |
topic |
Multidisciplinary |
url |
http://dx.doi.org/10.1073/pnas.1321542111 |
publishDate |
2014 |
physical |
6419-6424 |
description |
<jats:title>Significance</jats:title>
<jats:p>
We have studied the functionality of an incomplete acetyl-CoA “Wood–Ljungdahl” pathway in a strictly organohalide-respiring bacterium,
<jats:italic>Dehalococcoides mccartyi</jats:italic>
. We found that in addition to its ability to incorporate exogenous formate, this pathway cleaves acetyl-CoA to generate methyl-tetrahydrofolate for methionine biosynthesis, serving as a unique substitute of the missing methylene-tetrahydrofolate reductase function. We also found that accumulation of carbon monoxide (CO), an obligate by-product from acetyl-CoA cleavage, inhibits
<jats:italic>D. mccartyi</jats:italic>
axenic cultures, but can be ameliorated by the presence of a CO-oxidizing organism, resulting in an unusual syntrophic association. The understanding of the products and biosynthetic functions of this incomplete Wood–Ljungdahl pathway improves our knowledge of alternate central metabolic strategies used by environmental microorganisms.
</jats:p> |
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author | Zhuang, Wei-Qin, Yi, Shan, Bill, Markus, Brisson, Vanessa L., Feng, Xueyang, Men, Yujie, Conrad, Mark E., Tang, Yinjie J., Alvarez-Cohen, Lisa |
author_facet | Zhuang, Wei-Qin, Yi, Shan, Bill, Markus, Brisson, Vanessa L., Feng, Xueyang, Men, Yujie, Conrad, Mark E., Tang, Yinjie J., Alvarez-Cohen, Lisa, Zhuang, Wei-Qin, Yi, Shan, Bill, Markus, Brisson, Vanessa L., Feng, Xueyang, Men, Yujie, Conrad, Mark E., Tang, Yinjie J., Alvarez-Cohen, Lisa |
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container_title | Proceedings of the National Academy of Sciences |
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description | <jats:title>Significance</jats:title> <jats:p> We have studied the functionality of an incomplete acetyl-CoA “Wood–Ljungdahl” pathway in a strictly organohalide-respiring bacterium, <jats:italic>Dehalococcoides mccartyi</jats:italic> . We found that in addition to its ability to incorporate exogenous formate, this pathway cleaves acetyl-CoA to generate methyl-tetrahydrofolate for methionine biosynthesis, serving as a unique substitute of the missing methylene-tetrahydrofolate reductase function. We also found that accumulation of carbon monoxide (CO), an obligate by-product from acetyl-CoA cleavage, inhibits <jats:italic>D. mccartyi</jats:italic> axenic cultures, but can be ameliorated by the presence of a CO-oxidizing organism, resulting in an unusual syntrophic association. The understanding of the products and biosynthetic functions of this incomplete Wood–Ljungdahl pathway improves our knowledge of alternate central metabolic strategies used by environmental microorganisms. </jats:p> |
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spelling | Zhuang, Wei-Qin Yi, Shan Bill, Markus Brisson, Vanessa L. Feng, Xueyang Men, Yujie Conrad, Mark E. Tang, Yinjie J. Alvarez-Cohen, Lisa 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1321542111 <jats:title>Significance</jats:title> <jats:p> We have studied the functionality of an incomplete acetyl-CoA “Wood–Ljungdahl” pathway in a strictly organohalide-respiring bacterium, <jats:italic>Dehalococcoides mccartyi</jats:italic> . We found that in addition to its ability to incorporate exogenous formate, this pathway cleaves acetyl-CoA to generate methyl-tetrahydrofolate for methionine biosynthesis, serving as a unique substitute of the missing methylene-tetrahydrofolate reductase function. We also found that accumulation of carbon monoxide (CO), an obligate by-product from acetyl-CoA cleavage, inhibits <jats:italic>D. mccartyi</jats:italic> axenic cultures, but can be ameliorated by the presence of a CO-oxidizing organism, resulting in an unusual syntrophic association. The understanding of the products and biosynthetic functions of this incomplete Wood–Ljungdahl pathway improves our knowledge of alternate central metabolic strategies used by environmental microorganisms. </jats:p> Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring <i>Dehalococcoides mccartyi</i> Proceedings of the National Academy of Sciences |
spellingShingle | Zhuang, Wei-Qin, Yi, Shan, Bill, Markus, Brisson, Vanessa L., Feng, Xueyang, Men, Yujie, Conrad, Mark E., Tang, Yinjie J., Alvarez-Cohen, Lisa, Proceedings of the National Academy of Sciences, Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi, Multidisciplinary |
title | Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_full | Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_fullStr | Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_full_unstemmed | Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_short | Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
title_sort | incomplete wood–ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring <i>dehalococcoides mccartyi</i> |
title_unstemmed | Incomplete Wood–Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi |
topic | Multidisciplinary |
url | http://dx.doi.org/10.1073/pnas.1321542111 |