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Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Proceedings of the National Academy of Sciences, 110, 2013, 52, S. 21048-21053 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
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Ma, Hanhui Reyes-Gutierrez, Pablo Pederson, Thoru Ma, Hanhui Reyes-Gutierrez, Pablo Pederson, Thoru |
|---|---|
| author |
Ma, Hanhui Reyes-Gutierrez, Pablo Pederson, Thoru |
| spellingShingle |
Ma, Hanhui Reyes-Gutierrez, Pablo Pederson, Thoru Proceedings of the National Academy of Sciences Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors Multidisciplinary |
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ma, hanhui |
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Ma, Hanhui Reyes-Gutierrez, Pablo Pederson, Thoru 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1319097110 <jats:title>Significance</jats:title> <jats:p>Repetitive DNA sequences such as telomeres and centromeres are, like the chromosomes in which they reside, highly dynamic within the interphase nucleus, moving about by diffusion. Live cell imaging of these specific chromosomal sites has been limited and the approach presented in this study, based on expressed transcription activator-like effector (TALE)-fluorescent proteins, offers new opportunities in basic research on chromosome dynamics. In parallel, the described use of fluorescent TALEs as probes with fixed cells presents advantages over fluorescent in situ hybridization and may find particular applications in clinical and diagnostic settings.</jats:p> Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors Proceedings of the National Academy of Sciences |
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| title |
Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| title_unstemmed |
Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| title_full |
Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| title_fullStr |
Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| title_full_unstemmed |
Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
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Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| title_sort |
visualization of repetitive dna sequences in human chromosomes with transcription activator-like effectors |
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Multidisciplinary |
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http://dx.doi.org/10.1073/pnas.1319097110 |
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2013 |
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21048-21053 |
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<jats:title>Significance</jats:title>
<jats:p>Repetitive DNA sequences such as telomeres and centromeres are, like the chromosomes in which they reside, highly dynamic within the interphase nucleus, moving about by diffusion. Live cell imaging of these specific chromosomal sites has been limited and the approach presented in this study, based on expressed transcription activator-like effector (TALE)-fluorescent proteins, offers new opportunities in basic research on chromosome dynamics. In parallel, the described use of fluorescent TALEs as probes with fixed cells presents advantages over fluorescent in situ hybridization and may find particular applications in clinical and diagnostic settings.</jats:p> |
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| author | Ma, Hanhui, Reyes-Gutierrez, Pablo, Pederson, Thoru |
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| description | <jats:title>Significance</jats:title> <jats:p>Repetitive DNA sequences such as telomeres and centromeres are, like the chromosomes in which they reside, highly dynamic within the interphase nucleus, moving about by diffusion. Live cell imaging of these specific chromosomal sites has been limited and the approach presented in this study, based on expressed transcription activator-like effector (TALE)-fluorescent proteins, offers new opportunities in basic research on chromosome dynamics. In parallel, the described use of fluorescent TALEs as probes with fixed cells presents advantages over fluorescent in situ hybridization and may find particular applications in clinical and diagnostic settings.</jats:p> |
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| spelling | Ma, Hanhui Reyes-Gutierrez, Pablo Pederson, Thoru 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1319097110 <jats:title>Significance</jats:title> <jats:p>Repetitive DNA sequences such as telomeres and centromeres are, like the chromosomes in which they reside, highly dynamic within the interphase nucleus, moving about by diffusion. Live cell imaging of these specific chromosomal sites has been limited and the approach presented in this study, based on expressed transcription activator-like effector (TALE)-fluorescent proteins, offers new opportunities in basic research on chromosome dynamics. In parallel, the described use of fluorescent TALEs as probes with fixed cells presents advantages over fluorescent in situ hybridization and may find particular applications in clinical and diagnostic settings.</jats:p> Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors Proceedings of the National Academy of Sciences |
| spellingShingle | Ma, Hanhui, Reyes-Gutierrez, Pablo, Pederson, Thoru, Proceedings of the National Academy of Sciences, Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors, Multidisciplinary |
| title | Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| title_full | Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| title_fullStr | Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| title_full_unstemmed | Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| title_short | Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| title_sort | visualization of repetitive dna sequences in human chromosomes with transcription activator-like effectors |
| title_unstemmed | Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1319097110 |