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Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 109, 2012, supplement_2, S. 17266-17272 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Suderman, Matthew McGowan, Patrick O. Sasaki, Aya Huang, Tony C. T. Hallett, Michael T. Meaney, Michael J. Turecki, Gustavo Szyf, Moshe Suderman, Matthew McGowan, Patrick O. Sasaki, Aya Huang, Tony C. T. Hallett, Michael T. Meaney, Michael J. Turecki, Gustavo Szyf, Moshe |
|---|---|
| author |
Suderman, Matthew McGowan, Patrick O. Sasaki, Aya Huang, Tony C. T. Hallett, Michael T. Meaney, Michael J. Turecki, Gustavo Szyf, Moshe |
| spellingShingle |
Suderman, Matthew McGowan, Patrick O. Sasaki, Aya Huang, Tony C. T. Hallett, Michael T. Meaney, Michael J. Turecki, Gustavo Szyf, Moshe Proceedings of the National Academy of Sciences Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus Multidisciplinary |
| author_sort |
suderman, matthew |
| spelling |
Suderman, Matthew McGowan, Patrick O. Sasaki, Aya Huang, Tony C. T. Hallett, Michael T. Meaney, Michael J. Turecki, Gustavo Szyf, Moshe 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1121260109 <jats:p> Early life experience is associated with long-term effects on behavior and epigenetic programming of the <jats:italic>NR3C1</jats:italic> ( <jats:italic>GLUCOCORTICOID RECEPTOR</jats:italic> ) gene in the hippocampus of both rats and humans. However, it is unlikely that such effects completely capture the evolutionarily conserved epigenetic mechanisms of early adaptation to environment. Here we present DNA methylation profiles spanning 6.5 million base pairs centered at the <jats:italic>NR3C1</jats:italic> gene in the hippocampus of humans who experienced abuse as children and nonabused controls. We compare these profiles to corresponding DNA methylation profiles in rats that received differential levels of maternal care. The profiles of both species reveal hundreds of DNA methylation differences associated with early life experience distributed across the entire region in nonrandom patterns. For instance, methylation differences tend to cluster by genomic location, forming clusters covering as many as 1 million bases. Even more surprisingly, these differences seem to specifically target regulatory regions such as gene promoters, particularly those of the protocadherin α, β, and γ gene families. Beyond these high-level similarities, more detailed analyses reveal methylation differences likely stemming from the significant biological and environmental differences between species. These results provide support for an analogous cross-species epigenetic regulatory response at the level of the genomic region to early life experience. </jats:p> Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus Proceedings of the National Academy of Sciences |
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| title |
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_unstemmed |
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_full |
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_fullStr |
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_full_unstemmed |
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_short |
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_sort |
conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.1121260109 |
| publishDate |
2012 |
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17266-17272 |
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<jats:p>
Early life experience is associated with long-term effects on behavior and epigenetic programming of the
<jats:italic>NR3C1</jats:italic>
(
<jats:italic>GLUCOCORTICOID RECEPTOR</jats:italic>
) gene in the hippocampus of both rats and humans. However, it is unlikely that such effects completely capture the evolutionarily conserved epigenetic mechanisms of early adaptation to environment. Here we present DNA methylation profiles spanning 6.5 million base pairs centered at the
<jats:italic>NR3C1</jats:italic>
gene in the hippocampus of humans who experienced abuse as children and nonabused controls. We compare these profiles to corresponding DNA methylation profiles in rats that received differential levels of maternal care. The profiles of both species reveal hundreds of DNA methylation differences associated with early life experience distributed across the entire region in nonrandom patterns. For instance, methylation differences tend to cluster by genomic location, forming clusters covering as many as 1 million bases. Even more surprisingly, these differences seem to specifically target regulatory regions such as gene promoters, particularly those of the protocadherin α, β, and γ gene families. Beyond these high-level similarities, more detailed analyses reveal methylation differences likely stemming from the significant biological and environmental differences between species. These results provide support for an analogous cross-species epigenetic regulatory response at the level of the genomic region to early life experience.
</jats:p> |
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| author | Suderman, Matthew, McGowan, Patrick O., Sasaki, Aya, Huang, Tony C. T., Hallett, Michael T., Meaney, Michael J., Turecki, Gustavo, Szyf, Moshe |
| author_facet | Suderman, Matthew, McGowan, Patrick O., Sasaki, Aya, Huang, Tony C. T., Hallett, Michael T., Meaney, Michael J., Turecki, Gustavo, Szyf, Moshe, Suderman, Matthew, McGowan, Patrick O., Sasaki, Aya, Huang, Tony C. T., Hallett, Michael T., Meaney, Michael J., Turecki, Gustavo, Szyf, Moshe |
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| description | <jats:p> Early life experience is associated with long-term effects on behavior and epigenetic programming of the <jats:italic>NR3C1</jats:italic> ( <jats:italic>GLUCOCORTICOID RECEPTOR</jats:italic> ) gene in the hippocampus of both rats and humans. However, it is unlikely that such effects completely capture the evolutionarily conserved epigenetic mechanisms of early adaptation to environment. Here we present DNA methylation profiles spanning 6.5 million base pairs centered at the <jats:italic>NR3C1</jats:italic> gene in the hippocampus of humans who experienced abuse as children and nonabused controls. We compare these profiles to corresponding DNA methylation profiles in rats that received differential levels of maternal care. The profiles of both species reveal hundreds of DNA methylation differences associated with early life experience distributed across the entire region in nonrandom patterns. For instance, methylation differences tend to cluster by genomic location, forming clusters covering as many as 1 million bases. Even more surprisingly, these differences seem to specifically target regulatory regions such as gene promoters, particularly those of the protocadherin α, β, and γ gene families. Beyond these high-level similarities, more detailed analyses reveal methylation differences likely stemming from the significant biological and environmental differences between species. These results provide support for an analogous cross-species epigenetic regulatory response at the level of the genomic region to early life experience. </jats:p> |
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| spelling | Suderman, Matthew McGowan, Patrick O. Sasaki, Aya Huang, Tony C. T. Hallett, Michael T. Meaney, Michael J. Turecki, Gustavo Szyf, Moshe 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1121260109 <jats:p> Early life experience is associated with long-term effects on behavior and epigenetic programming of the <jats:italic>NR3C1</jats:italic> ( <jats:italic>GLUCOCORTICOID RECEPTOR</jats:italic> ) gene in the hippocampus of both rats and humans. However, it is unlikely that such effects completely capture the evolutionarily conserved epigenetic mechanisms of early adaptation to environment. Here we present DNA methylation profiles spanning 6.5 million base pairs centered at the <jats:italic>NR3C1</jats:italic> gene in the hippocampus of humans who experienced abuse as children and nonabused controls. We compare these profiles to corresponding DNA methylation profiles in rats that received differential levels of maternal care. The profiles of both species reveal hundreds of DNA methylation differences associated with early life experience distributed across the entire region in nonrandom patterns. For instance, methylation differences tend to cluster by genomic location, forming clusters covering as many as 1 million bases. Even more surprisingly, these differences seem to specifically target regulatory regions such as gene promoters, particularly those of the protocadherin α, β, and γ gene families. Beyond these high-level similarities, more detailed analyses reveal methylation differences likely stemming from the significant biological and environmental differences between species. These results provide support for an analogous cross-species epigenetic regulatory response at the level of the genomic region to early life experience. </jats:p> Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus Proceedings of the National Academy of Sciences |
| spellingShingle | Suderman, Matthew, McGowan, Patrick O., Sasaki, Aya, Huang, Tony C. T., Hallett, Michael T., Meaney, Michael J., Turecki, Gustavo, Szyf, Moshe, Proceedings of the National Academy of Sciences, Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus, Multidisciplinary |
| title | Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_full | Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_fullStr | Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_full_unstemmed | Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_short | Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_sort | conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| title_unstemmed | Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1121260109 |