Eintrag weiter verarbeiten
Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations
Gespeichert in:
| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Proceedings of the National Academy of Sciences, 109, 2012, 2, S. 606-609 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Butler, Thomas Charles Benayoun, Marc Wallace, Edward van Drongelen, Wim Goldenfeld, Nigel Cowan, Jack Butler, Thomas Charles Benayoun, Marc Wallace, Edward van Drongelen, Wim Goldenfeld, Nigel Cowan, Jack |
|---|---|
| author |
Butler, Thomas Charles Benayoun, Marc Wallace, Edward van Drongelen, Wim Goldenfeld, Nigel Cowan, Jack |
| spellingShingle |
Butler, Thomas Charles Benayoun, Marc Wallace, Edward van Drongelen, Wim Goldenfeld, Nigel Cowan, Jack Proceedings of the National Academy of Sciences Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations Multidisciplinary |
| author_sort |
butler, thomas charles |
| spelling |
Butler, Thomas Charles Benayoun, Marc Wallace, Edward van Drongelen, Wim Goldenfeld, Nigel Cowan, Jack 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1118672109 <jats:p>In the cat or primate primary visual cortex (V1), normal vision corresponds to a state where neural excitation patterns are driven by external visual stimuli. A spectacular failure mode of V1 occurs when such patterns are overwhelmed by spontaneously generated spatially self-organized patterns of neural excitation. These are experienced as geometric visual hallucinations. The problem of identifying the mechanisms by which V1 avoids this failure is made acute by recent advances in the statistical mechanics of pattern formation, which suggest that the hallucinatory state should be very robust. Here, we report how incorporating physiologically realistic long-range connections between inhibitory neurons changes the behavior of a model of V1. We find that the sparsity of long-range inhibition in V1 plays a previously unrecognized but key functional role in preserving the normal vision state. Surprisingly, it also contributes to the observed regularity of geometric visual hallucinations. Our results provide an explanation for the observed sparsity of long-range inhibition in V1—this generic architectural feature is an evolutionary adaptation that tunes V1 to the normal vision state. In addition, it has been shown that exactly the same long-range connections play a key role in the development of orientation preference maps. Thus V1’s most striking long-range features—patchy excitatory connections and sparse inhibitory connections—are strongly constrained by two requirements: the need for the visual state to be robust and the developmental requirements of the orientational preference map.</jats:p> Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations Proceedings of the National Academy of Sciences |
| doi_str_mv |
10.1073/pnas.1118672109 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjExMTg2NzIxMDk |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjExMTg2NzIxMDk |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Proceedings of the National Academy of Sciences, 2012 |
| imprint_str_mv |
Proceedings of the National Academy of Sciences, 2012 |
| issn |
0027-8424 1091-6490 |
| issn_str_mv |
0027-8424 1091-6490 |
| language |
English |
| mega_collection |
Proceedings of the National Academy of Sciences (CrossRef) |
| match_str |
butler2012evolutionaryconstraintsonvisualcortexarchitecturefromthedynamicsofhallucinations |
| publishDateSort |
2012 |
| publisher |
Proceedings of the National Academy of Sciences |
| recordtype |
ai |
| record_format |
ai |
| series |
Proceedings of the National Academy of Sciences |
| source_id |
49 |
| title |
Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_unstemmed |
Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_full |
Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_fullStr |
Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_full_unstemmed |
Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_short |
Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_sort |
evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.1118672109 |
| publishDate |
2012 |
| physical |
606-609 |
| description |
<jats:p>In the cat or primate primary visual cortex (V1), normal vision corresponds to a state where neural excitation patterns are driven by external visual stimuli. A spectacular failure mode of V1 occurs when such patterns are overwhelmed by spontaneously generated spatially self-organized patterns of neural excitation. These are experienced as geometric visual hallucinations. The problem of identifying the mechanisms by which V1 avoids this failure is made acute by recent advances in the statistical mechanics of pattern formation, which suggest that the hallucinatory state should be very robust. Here, we report how incorporating physiologically realistic long-range connections between inhibitory neurons changes the behavior of a model of V1. We find that the sparsity of long-range inhibition in V1 plays a previously unrecognized but key functional role in preserving the normal vision state. Surprisingly, it also contributes to the observed regularity of geometric visual hallucinations. Our results provide an explanation for the observed sparsity of long-range inhibition in V1—this generic architectural feature is an evolutionary adaptation that tunes V1 to the normal vision state. In addition, it has been shown that exactly the same long-range connections play a key role in the development of orientation preference maps. Thus V1’s most striking long-range features—patchy excitatory connections and sparse inhibitory connections—are strongly constrained by two requirements: the need for the visual state to be robust and the developmental requirements of the orientational preference map.</jats:p> |
| container_issue |
2 |
| container_start_page |
606 |
| container_title |
Proceedings of the National Academy of Sciences |
| container_volume |
109 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792345484300386312 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:24:13.885Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Evolutionary+constraints+on+visual+cortex+architecture+from+the+dynamics+of+hallucinations&rft.date=2012-01-10&genre=article&issn=1091-6490&volume=109&issue=2&spage=606&epage=609&pages=606-609&jtitle=Proceedings+of+the+National+Academy+of+Sciences&atitle=Evolutionary+constraints+on+visual+cortex+architecture+from+the+dynamics+of+hallucinations&aulast=Cowan&aufirst=Jack&rft_id=info%3Adoi%2F10.1073%2Fpnas.1118672109&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792345484300386312 |
| author | Butler, Thomas Charles, Benayoun, Marc, Wallace, Edward, van Drongelen, Wim, Goldenfeld, Nigel, Cowan, Jack |
| author_facet | Butler, Thomas Charles, Benayoun, Marc, Wallace, Edward, van Drongelen, Wim, Goldenfeld, Nigel, Cowan, Jack, Butler, Thomas Charles, Benayoun, Marc, Wallace, Edward, van Drongelen, Wim, Goldenfeld, Nigel, Cowan, Jack |
| author_sort | butler, thomas charles |
| container_issue | 2 |
| container_start_page | 606 |
| container_title | Proceedings of the National Academy of Sciences |
| container_volume | 109 |
| description | <jats:p>In the cat or primate primary visual cortex (V1), normal vision corresponds to a state where neural excitation patterns are driven by external visual stimuli. A spectacular failure mode of V1 occurs when such patterns are overwhelmed by spontaneously generated spatially self-organized patterns of neural excitation. These are experienced as geometric visual hallucinations. The problem of identifying the mechanisms by which V1 avoids this failure is made acute by recent advances in the statistical mechanics of pattern formation, which suggest that the hallucinatory state should be very robust. Here, we report how incorporating physiologically realistic long-range connections between inhibitory neurons changes the behavior of a model of V1. We find that the sparsity of long-range inhibition in V1 plays a previously unrecognized but key functional role in preserving the normal vision state. Surprisingly, it also contributes to the observed regularity of geometric visual hallucinations. Our results provide an explanation for the observed sparsity of long-range inhibition in V1—this generic architectural feature is an evolutionary adaptation that tunes V1 to the normal vision state. In addition, it has been shown that exactly the same long-range connections play a key role in the development of orientation preference maps. Thus V1’s most striking long-range features—patchy excitatory connections and sparse inhibitory connections—are strongly constrained by two requirements: the need for the visual state to be robust and the developmental requirements of the orientational preference map.</jats:p> |
| doi_str_mv | 10.1073/pnas.1118672109 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjExMTg2NzIxMDk |
| imprint | Proceedings of the National Academy of Sciences, 2012 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 2012 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0027-8424, 1091-6490 |
| issn_str_mv | 0027-8424, 1091-6490 |
| language | English |
| last_indexed | 2024-03-01T17:24:13.885Z |
| match_str | butler2012evolutionaryconstraintsonvisualcortexarchitecturefromthedynamicsofhallucinations |
| mega_collection | Proceedings of the National Academy of Sciences (CrossRef) |
| physical | 606-609 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | ai |
| recordtype | ai |
| series | Proceedings of the National Academy of Sciences |
| source_id | 49 |
| spelling | Butler, Thomas Charles Benayoun, Marc Wallace, Edward van Drongelen, Wim Goldenfeld, Nigel Cowan, Jack 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1118672109 <jats:p>In the cat or primate primary visual cortex (V1), normal vision corresponds to a state where neural excitation patterns are driven by external visual stimuli. A spectacular failure mode of V1 occurs when such patterns are overwhelmed by spontaneously generated spatially self-organized patterns of neural excitation. These are experienced as geometric visual hallucinations. The problem of identifying the mechanisms by which V1 avoids this failure is made acute by recent advances in the statistical mechanics of pattern formation, which suggest that the hallucinatory state should be very robust. Here, we report how incorporating physiologically realistic long-range connections between inhibitory neurons changes the behavior of a model of V1. We find that the sparsity of long-range inhibition in V1 plays a previously unrecognized but key functional role in preserving the normal vision state. Surprisingly, it also contributes to the observed regularity of geometric visual hallucinations. Our results provide an explanation for the observed sparsity of long-range inhibition in V1—this generic architectural feature is an evolutionary adaptation that tunes V1 to the normal vision state. In addition, it has been shown that exactly the same long-range connections play a key role in the development of orientation preference maps. Thus V1’s most striking long-range features—patchy excitatory connections and sparse inhibitory connections—are strongly constrained by two requirements: the need for the visual state to be robust and the developmental requirements of the orientational preference map.</jats:p> Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations Proceedings of the National Academy of Sciences |
| spellingShingle | Butler, Thomas Charles, Benayoun, Marc, Wallace, Edward, van Drongelen, Wim, Goldenfeld, Nigel, Cowan, Jack, Proceedings of the National Academy of Sciences, Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations, Multidisciplinary |
| title | Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_full | Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_fullStr | Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_full_unstemmed | Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_short | Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_sort | evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| title_unstemmed | Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1118672109 |