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Hippocampal long-term depression is required for the consolidation of spatial memory
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 107, 2010, 38, S. 16697-16702 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| author_facet |
Ge, Yuan Dong, Zhifang Bagot, Rosemary C. Howland, John G. Phillips, Anthony G. Wong, Tak Pan Wang, Yu Tian Ge, Yuan Dong, Zhifang Bagot, Rosemary C. Howland, John G. Phillips, Anthony G. Wong, Tak Pan Wang, Yu Tian |
|---|---|
| author |
Ge, Yuan Dong, Zhifang Bagot, Rosemary C. Howland, John G. Phillips, Anthony G. Wong, Tak Pan Wang, Yu Tian |
| spellingShingle |
Ge, Yuan Dong, Zhifang Bagot, Rosemary C. Howland, John G. Phillips, Anthony G. Wong, Tak Pan Wang, Yu Tian Proceedings of the National Academy of Sciences Hippocampal long-term depression is required for the consolidation of spatial memory Multidisciplinary |
| author_sort |
ge, yuan |
| spelling |
Ge, Yuan Dong, Zhifang Bagot, Rosemary C. Howland, John G. Phillips, Anthony G. Wong, Tak Pan Wang, Yu Tian 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1008200107 <jats:p>Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term spatial memory, the precise contributions of LTP and LTD remain poorly understood. Here, we report that LTP and LTD in the hippocampal CA1 region of freely moving adult rats were prevented by NMDAR 2A (GluN2A) and 2B subunit (GluN2B) preferential antagonists, respectively. These results strongly suggest that NMDAR subtype preferential antagonists are appropriate tools to probe the roles of LTP and LTD in spatial memory. Using a Morris water maze task, the LTP-blocking GluN2A antagonist had no significant effect on any aspect of performance, whereas the LTD-blocking GluN2B antagonist impaired spatial memory consolidation. Moreover, similar spatial memory deficits were induced by inhibiting the expression of LTD with intrahippocampal infusion of a short peptide that specifically interferes with AMPA receptor endocytosis. Taken together, our findings support a functional requirement of hippocampal CA1 LTD in the consolidation of long-term spatial memory.</jats:p> Hippocampal long-term depression is required for the consolidation of spatial memory Proceedings of the National Academy of Sciences |
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| title |
Hippocampal long-term depression is required for the consolidation of spatial memory |
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Hippocampal long-term depression is required for the consolidation of spatial memory |
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Hippocampal long-term depression is required for the consolidation of spatial memory |
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Hippocampal long-term depression is required for the consolidation of spatial memory |
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Hippocampal long-term depression is required for the consolidation of spatial memory |
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Hippocampal long-term depression is required for the consolidation of spatial memory |
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hippocampal long-term depression is required for the consolidation of spatial memory |
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Multidisciplinary |
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http://dx.doi.org/10.1073/pnas.1008200107 |
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2010 |
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16697-16702 |
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<jats:p>Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term spatial memory, the precise contributions of LTP and LTD remain poorly understood. Here, we report that LTP and LTD in the hippocampal CA1 region of freely moving adult rats were prevented by NMDAR 2A (GluN2A) and 2B subunit (GluN2B) preferential antagonists, respectively. These results strongly suggest that NMDAR subtype preferential antagonists are appropriate tools to probe the roles of LTP and LTD in spatial memory. Using a Morris water maze task, the LTP-blocking GluN2A antagonist had no significant effect on any aspect of performance, whereas the LTD-blocking GluN2B antagonist impaired spatial memory consolidation. Moreover, similar spatial memory deficits were induced by inhibiting the expression of LTD with intrahippocampal infusion of a short peptide that specifically interferes with AMPA receptor endocytosis. Taken together, our findings support a functional requirement of hippocampal CA1 LTD in the consolidation of long-term spatial memory.</jats:p> |
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| author | Ge, Yuan, Dong, Zhifang, Bagot, Rosemary C., Howland, John G., Phillips, Anthony G., Wong, Tak Pan, Wang, Yu Tian |
| author_facet | Ge, Yuan, Dong, Zhifang, Bagot, Rosemary C., Howland, John G., Phillips, Anthony G., Wong, Tak Pan, Wang, Yu Tian, Ge, Yuan, Dong, Zhifang, Bagot, Rosemary C., Howland, John G., Phillips, Anthony G., Wong, Tak Pan, Wang, Yu Tian |
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| description | <jats:p>Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term spatial memory, the precise contributions of LTP and LTD remain poorly understood. Here, we report that LTP and LTD in the hippocampal CA1 region of freely moving adult rats were prevented by NMDAR 2A (GluN2A) and 2B subunit (GluN2B) preferential antagonists, respectively. These results strongly suggest that NMDAR subtype preferential antagonists are appropriate tools to probe the roles of LTP and LTD in spatial memory. Using a Morris water maze task, the LTP-blocking GluN2A antagonist had no significant effect on any aspect of performance, whereas the LTD-blocking GluN2B antagonist impaired spatial memory consolidation. Moreover, similar spatial memory deficits were induced by inhibiting the expression of LTD with intrahippocampal infusion of a short peptide that specifically interferes with AMPA receptor endocytosis. Taken together, our findings support a functional requirement of hippocampal CA1 LTD in the consolidation of long-term spatial memory.</jats:p> |
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| spelling | Ge, Yuan Dong, Zhifang Bagot, Rosemary C. Howland, John G. Phillips, Anthony G. Wong, Tak Pan Wang, Yu Tian 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1008200107 <jats:p>Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term spatial memory, the precise contributions of LTP and LTD remain poorly understood. Here, we report that LTP and LTD in the hippocampal CA1 region of freely moving adult rats were prevented by NMDAR 2A (GluN2A) and 2B subunit (GluN2B) preferential antagonists, respectively. These results strongly suggest that NMDAR subtype preferential antagonists are appropriate tools to probe the roles of LTP and LTD in spatial memory. Using a Morris water maze task, the LTP-blocking GluN2A antagonist had no significant effect on any aspect of performance, whereas the LTD-blocking GluN2B antagonist impaired spatial memory consolidation. Moreover, similar spatial memory deficits were induced by inhibiting the expression of LTD with intrahippocampal infusion of a short peptide that specifically interferes with AMPA receptor endocytosis. Taken together, our findings support a functional requirement of hippocampal CA1 LTD in the consolidation of long-term spatial memory.</jats:p> Hippocampal long-term depression is required for the consolidation of spatial memory Proceedings of the National Academy of Sciences |
| spellingShingle | Ge, Yuan, Dong, Zhifang, Bagot, Rosemary C., Howland, John G., Phillips, Anthony G., Wong, Tak Pan, Wang, Yu Tian, Proceedings of the National Academy of Sciences, Hippocampal long-term depression is required for the consolidation of spatial memory, Multidisciplinary |
| title | Hippocampal long-term depression is required for the consolidation of spatial memory |
| title_full | Hippocampal long-term depression is required for the consolidation of spatial memory |
| title_fullStr | Hippocampal long-term depression is required for the consolidation of spatial memory |
| title_full_unstemmed | Hippocampal long-term depression is required for the consolidation of spatial memory |
| title_short | Hippocampal long-term depression is required for the consolidation of spatial memory |
| title_sort | hippocampal long-term depression is required for the consolidation of spatial memory |
| title_unstemmed | Hippocampal long-term depression is required for the consolidation of spatial memory |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1008200107 |