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Differential modulation of global and local neural oscillations in REM sleep by homeostatic sleep regulation
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
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| Personen und Körperschaften: | , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 114, 2017, 9 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>Significance</jats:title> <jats:p>This study demonstrates that slow and fast cortical oscillations undergo different adaptations to homeostatic challenge of chronic sleep deprivation, which may benefit different functions of sleep. When mice sleep only 6 h/d for 5 d, rapid eye movement (REM) sleep settles on a persistently elevated level, even though sleep debt continues to accumulate. Using high-density EEG, we found that different forms of slow oscillations follow this general pattern, whereas all high-frequency oscillations showed progressive daily increases. Slow and fast oscillations play distinct roles in coordination of brain cell activity on different scales, and thus our results help to reconcile two seemingly opposite functions of sleep in synaptic homeostasis and sleep-dependent memory consolidation.</jats:p> |
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| ISSN: |
0027-8424
1091-6490 |
| DOI: | 10.1073/pnas.1615230114 |