Eintrag weiter verarbeiten
CXCL13 is a plasma biomarker of germinal center activity
Gespeichert in:
| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 113, 2016, 10, S. 2702-2707 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Havenar-Daughton, Colin Lindqvist, Madelene Heit, Antje Wu, Jennifer E. Reiss, Samantha M. Kendric, Kayla Bélanger, Simon Kasturi, Sudhir Pai Landais, Elise Akondy, Rama S. McGuire, Helen M. Bothwell, Marcella Vagefi, Parsia A. Scully, Eileen Tomaras, Georgia D. Davis, Mark M. Poignard, Pascal Ahmed, Rafi Walker, Bruce D. Pulendran, Bali McElrath, M. Juliana Kaufmann, Daniel E. Crotty, Shane Price, Matt A. Gilmour, Jill Fast, Pat Kamali, Anatoli Sanders, Eduard J. Onzala, Omu Allen, Susan Hunter, Eric Karita, Etienne Kilembe, William Lakhi, Shabir Inambao, Mubiana Havenar-Daughton, Colin Lindqvist, Madelene Heit, Antje Wu, Jennifer E. Reiss, Samantha M. Kendric, Kayla Bélanger, Simon Kasturi, Sudhir Pai Landais, Elise Akondy, Rama S. McGuire, Helen M. Bothwell, Marcella Vagefi, Parsia A. Scully, Eileen Tomaras, Georgia D. Davis, Mark M. Poignard, Pascal Ahmed, Rafi Walker, Bruce D. Pulendran, Bali McElrath, M. Juliana Kaufmann, Daniel E. Crotty, Shane Price, Matt A. Gilmour, Jill Fast, Pat Kamali, Anatoli Sanders, Eduard J. Onzala, Omu Allen, Susan Hunter, Eric Karita, Etienne Kilembe, William Lakhi, Shabir Inambao, Mubiana |
|---|---|
| author |
Havenar-Daughton, Colin Lindqvist, Madelene Heit, Antje Wu, Jennifer E. Reiss, Samantha M. Kendric, Kayla Bélanger, Simon Kasturi, Sudhir Pai Landais, Elise Akondy, Rama S. McGuire, Helen M. Bothwell, Marcella Vagefi, Parsia A. Scully, Eileen Tomaras, Georgia D. Davis, Mark M. Poignard, Pascal Ahmed, Rafi Walker, Bruce D. Pulendran, Bali McElrath, M. Juliana Kaufmann, Daniel E. Crotty, Shane Price, Matt A. Gilmour, Jill Fast, Pat Kamali, Anatoli Sanders, Eduard J. Onzala, Omu Allen, Susan Hunter, Eric Karita, Etienne Kilembe, William Lakhi, Shabir Inambao, Mubiana |
| spellingShingle |
Havenar-Daughton, Colin Lindqvist, Madelene Heit, Antje Wu, Jennifer E. Reiss, Samantha M. Kendric, Kayla Bélanger, Simon Kasturi, Sudhir Pai Landais, Elise Akondy, Rama S. McGuire, Helen M. Bothwell, Marcella Vagefi, Parsia A. Scully, Eileen Tomaras, Georgia D. Davis, Mark M. Poignard, Pascal Ahmed, Rafi Walker, Bruce D. Pulendran, Bali McElrath, M. Juliana Kaufmann, Daniel E. Crotty, Shane Price, Matt A. Gilmour, Jill Fast, Pat Kamali, Anatoli Sanders, Eduard J. Onzala, Omu Allen, Susan Hunter, Eric Karita, Etienne Kilembe, William Lakhi, Shabir Inambao, Mubiana Proceedings of the National Academy of Sciences CXCL13 is a plasma biomarker of germinal center activity Multidisciplinary |
| author_sort |
havenar-daughton, colin |
| spelling |
Havenar-Daughton, Colin Lindqvist, Madelene Heit, Antje Wu, Jennifer E. Reiss, Samantha M. Kendric, Kayla Bélanger, Simon Kasturi, Sudhir Pai Landais, Elise Akondy, Rama S. McGuire, Helen M. Bothwell, Marcella Vagefi, Parsia A. Scully, Eileen Tomaras, Georgia D. Davis, Mark M. Poignard, Pascal Ahmed, Rafi Walker, Bruce D. Pulendran, Bali McElrath, M. Juliana Kaufmann, Daniel E. Crotty, Shane Price, Matt A. Gilmour, Jill Fast, Pat Kamali, Anatoli Sanders, Eduard J. Onzala, Omu Allen, Susan Hunter, Eric Karita, Etienne Kilembe, William Lakhi, Shabir Inambao, Mubiana 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1520112113 <jats:title>Significance</jats:title> <jats:p>A major challenge for vaccine science is that there is no way to measure germinal center activity in humans. This challenge is particularly acute for human clinical trials of candidate vaccines (and most nonhuman primate studies of candidate vaccines), because germinal centers are the engines of Ab affinity maturation, and generation of highly affinity-matured Ab responses is the goal of all Ab-eliciting vaccines. Here, we report that we have identified the chemokine CXCL13 [chemokine (C-X-C motif) ligand 13] as a biomarker of germinal center activity. We show explicit relationships between plasma CXCL13 concentrations and germinal center frequencies in lymph nodes in a series of different conditions, including licensed and experimental vaccines, and in humans, nonhuman primates, and mice.</jats:p> CXCL13 is a plasma biomarker of germinal center activity Proceedings of the National Academy of Sciences |
| doi_str_mv |
10.1073/pnas.1520112113 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjE1MjAxMTIxMTM |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjE1MjAxMTIxMTM |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
Proceedings of the National Academy of Sciences, 2016 |
| imprint_str_mv |
Proceedings of the National Academy of Sciences, 2016 |
| issn |
0027-8424 1091-6490 |
| issn_str_mv |
0027-8424 1091-6490 |
| language |
English |
| mega_collection |
Proceedings of the National Academy of Sciences (CrossRef) |
| match_str |
havenardaughton2016cxcl13isaplasmabiomarkerofgerminalcenteractivity |
| publishDateSort |
2016 |
| publisher |
Proceedings of the National Academy of Sciences |
| recordtype |
ai |
| record_format |
ai |
| series |
Proceedings of the National Academy of Sciences |
| source_id |
49 |
| title |
CXCL13 is a plasma biomarker of germinal center activity |
| title_unstemmed |
CXCL13 is a plasma biomarker of germinal center activity |
| title_full |
CXCL13 is a plasma biomarker of germinal center activity |
| title_fullStr |
CXCL13 is a plasma biomarker of germinal center activity |
| title_full_unstemmed |
CXCL13 is a plasma biomarker of germinal center activity |
| title_short |
CXCL13 is a plasma biomarker of germinal center activity |
| title_sort |
cxcl13 is a plasma biomarker of germinal center activity |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.1520112113 |
| publishDate |
2016 |
| physical |
2702-2707 |
| description |
<jats:title>Significance</jats:title>
<jats:p>A major challenge for vaccine science is that there is no way to measure germinal center activity in humans. This challenge is particularly acute for human clinical trials of candidate vaccines (and most nonhuman primate studies of candidate vaccines), because germinal centers are the engines of Ab affinity maturation, and generation of highly affinity-matured Ab responses is the goal of all Ab-eliciting vaccines. Here, we report that we have identified the chemokine CXCL13 [chemokine (C-X-C motif) ligand 13] as a biomarker of germinal center activity. We show explicit relationships between plasma CXCL13 concentrations and germinal center frequencies in lymph nodes in a series of different conditions, including licensed and experimental vaccines, and in humans, nonhuman primates, and mice.</jats:p> |
| container_issue |
10 |
| container_start_page |
2702 |
| container_title |
Proceedings of the National Academy of Sciences |
| container_volume |
113 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792348888110202885 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T18:18:19.523Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=CXCL13+is+a+plasma+biomarker+of+germinal+center+activity&rft.date=2016-03-08&genre=article&issn=1091-6490&volume=113&issue=10&spage=2702&epage=2707&pages=2702-2707&jtitle=Proceedings+of+the+National+Academy+of+Sciences&atitle=CXCL13+is+a+plasma+biomarker+of+germinal+center+activity&aulast=Inambao&aufirst=Mubiana&rft_id=info%3Adoi%2F10.1073%2Fpnas.1520112113&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792348888110202885 |
| author | Havenar-Daughton, Colin, Lindqvist, Madelene, Heit, Antje, Wu, Jennifer E., Reiss, Samantha M., Kendric, Kayla, Bélanger, Simon, Kasturi, Sudhir Pai, Landais, Elise, Akondy, Rama S., McGuire, Helen M., Bothwell, Marcella, Vagefi, Parsia A., Scully, Eileen, Tomaras, Georgia D., Davis, Mark M., Poignard, Pascal, Ahmed, Rafi, Walker, Bruce D., Pulendran, Bali, McElrath, M. Juliana, Kaufmann, Daniel E., Crotty, Shane, Price, Matt A., Gilmour, Jill, Fast, Pat, Kamali, Anatoli, Sanders, Eduard J., Onzala, Omu, Allen, Susan, Hunter, Eric, Karita, Etienne, Kilembe, William, Lakhi, Shabir, Inambao, Mubiana |
| author_facet | Havenar-Daughton, Colin, Lindqvist, Madelene, Heit, Antje, Wu, Jennifer E., Reiss, Samantha M., Kendric, Kayla, Bélanger, Simon, Kasturi, Sudhir Pai, Landais, Elise, Akondy, Rama S., McGuire, Helen M., Bothwell, Marcella, Vagefi, Parsia A., Scully, Eileen, Tomaras, Georgia D., Davis, Mark M., Poignard, Pascal, Ahmed, Rafi, Walker, Bruce D., Pulendran, Bali, McElrath, M. Juliana, Kaufmann, Daniel E., Crotty, Shane, Price, Matt A., Gilmour, Jill, Fast, Pat, Kamali, Anatoli, Sanders, Eduard J., Onzala, Omu, Allen, Susan, Hunter, Eric, Karita, Etienne, Kilembe, William, Lakhi, Shabir, Inambao, Mubiana, Havenar-Daughton, Colin, Lindqvist, Madelene, Heit, Antje, Wu, Jennifer E., Reiss, Samantha M., Kendric, Kayla, Bélanger, Simon, Kasturi, Sudhir Pai, Landais, Elise, Akondy, Rama S., McGuire, Helen M., Bothwell, Marcella, Vagefi, Parsia A., Scully, Eileen, Tomaras, Georgia D., Davis, Mark M., Poignard, Pascal, Ahmed, Rafi, Walker, Bruce D., Pulendran, Bali, McElrath, M. Juliana, Kaufmann, Daniel E., Crotty, Shane, Price, Matt A., Gilmour, Jill, Fast, Pat, Kamali, Anatoli, Sanders, Eduard J., Onzala, Omu, Allen, Susan, Hunter, Eric, Karita, Etienne, Kilembe, William, Lakhi, Shabir, Inambao, Mubiana |
| author_sort | havenar-daughton, colin |
| container_issue | 10 |
| container_start_page | 2702 |
| container_title | Proceedings of the National Academy of Sciences |
| container_volume | 113 |
| description | <jats:title>Significance</jats:title> <jats:p>A major challenge for vaccine science is that there is no way to measure germinal center activity in humans. This challenge is particularly acute for human clinical trials of candidate vaccines (and most nonhuman primate studies of candidate vaccines), because germinal centers are the engines of Ab affinity maturation, and generation of highly affinity-matured Ab responses is the goal of all Ab-eliciting vaccines. Here, we report that we have identified the chemokine CXCL13 [chemokine (C-X-C motif) ligand 13] as a biomarker of germinal center activity. We show explicit relationships between plasma CXCL13 concentrations and germinal center frequencies in lymph nodes in a series of different conditions, including licensed and experimental vaccines, and in humans, nonhuman primates, and mice.</jats:p> |
| doi_str_mv | 10.1073/pnas.1520112113 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjE1MjAxMTIxMTM |
| imprint | Proceedings of the National Academy of Sciences, 2016 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 2016 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0027-8424, 1091-6490 |
| issn_str_mv | 0027-8424, 1091-6490 |
| language | English |
| last_indexed | 2024-03-01T18:18:19.523Z |
| match_str | havenardaughton2016cxcl13isaplasmabiomarkerofgerminalcenteractivity |
| mega_collection | Proceedings of the National Academy of Sciences (CrossRef) |
| physical | 2702-2707 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | ai |
| recordtype | ai |
| series | Proceedings of the National Academy of Sciences |
| source_id | 49 |
| spelling | Havenar-Daughton, Colin Lindqvist, Madelene Heit, Antje Wu, Jennifer E. Reiss, Samantha M. Kendric, Kayla Bélanger, Simon Kasturi, Sudhir Pai Landais, Elise Akondy, Rama S. McGuire, Helen M. Bothwell, Marcella Vagefi, Parsia A. Scully, Eileen Tomaras, Georgia D. Davis, Mark M. Poignard, Pascal Ahmed, Rafi Walker, Bruce D. Pulendran, Bali McElrath, M. Juliana Kaufmann, Daniel E. Crotty, Shane Price, Matt A. Gilmour, Jill Fast, Pat Kamali, Anatoli Sanders, Eduard J. Onzala, Omu Allen, Susan Hunter, Eric Karita, Etienne Kilembe, William Lakhi, Shabir Inambao, Mubiana 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1520112113 <jats:title>Significance</jats:title> <jats:p>A major challenge for vaccine science is that there is no way to measure germinal center activity in humans. This challenge is particularly acute for human clinical trials of candidate vaccines (and most nonhuman primate studies of candidate vaccines), because germinal centers are the engines of Ab affinity maturation, and generation of highly affinity-matured Ab responses is the goal of all Ab-eliciting vaccines. Here, we report that we have identified the chemokine CXCL13 [chemokine (C-X-C motif) ligand 13] as a biomarker of germinal center activity. We show explicit relationships between plasma CXCL13 concentrations and germinal center frequencies in lymph nodes in a series of different conditions, including licensed and experimental vaccines, and in humans, nonhuman primates, and mice.</jats:p> CXCL13 is a plasma biomarker of germinal center activity Proceedings of the National Academy of Sciences |
| spellingShingle | Havenar-Daughton, Colin, Lindqvist, Madelene, Heit, Antje, Wu, Jennifer E., Reiss, Samantha M., Kendric, Kayla, Bélanger, Simon, Kasturi, Sudhir Pai, Landais, Elise, Akondy, Rama S., McGuire, Helen M., Bothwell, Marcella, Vagefi, Parsia A., Scully, Eileen, Tomaras, Georgia D., Davis, Mark M., Poignard, Pascal, Ahmed, Rafi, Walker, Bruce D., Pulendran, Bali, McElrath, M. Juliana, Kaufmann, Daniel E., Crotty, Shane, Price, Matt A., Gilmour, Jill, Fast, Pat, Kamali, Anatoli, Sanders, Eduard J., Onzala, Omu, Allen, Susan, Hunter, Eric, Karita, Etienne, Kilembe, William, Lakhi, Shabir, Inambao, Mubiana, Proceedings of the National Academy of Sciences, CXCL13 is a plasma biomarker of germinal center activity, Multidisciplinary |
| title | CXCL13 is a plasma biomarker of germinal center activity |
| title_full | CXCL13 is a plasma biomarker of germinal center activity |
| title_fullStr | CXCL13 is a plasma biomarker of germinal center activity |
| title_full_unstemmed | CXCL13 is a plasma biomarker of germinal center activity |
| title_short | CXCL13 is a plasma biomarker of germinal center activity |
| title_sort | cxcl13 is a plasma biomarker of germinal center activity |
| title_unstemmed | CXCL13 is a plasma biomarker of germinal center activity |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1520112113 |