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Neuronal necrosis is regulated by a conserved chromatin-modifying cascade
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 111, 2014, 38, S. 13960-13965 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| author_facet |
Liu, Kai Ding, Lianggong Li, Yuhong Yang, Hui Zhao, Chunyue Lei, Ye Han, Shuting Tao, Wei Miao, Dengshun Steller, Hermann Welsh, Michael J. Liu, Lei Liu, Kai Ding, Lianggong Li, Yuhong Yang, Hui Zhao, Chunyue Lei, Ye Han, Shuting Tao, Wei Miao, Dengshun Steller, Hermann Welsh, Michael J. Liu, Lei |
|---|---|
| author |
Liu, Kai Ding, Lianggong Li, Yuhong Yang, Hui Zhao, Chunyue Lei, Ye Han, Shuting Tao, Wei Miao, Dengshun Steller, Hermann Welsh, Michael J. Liu, Lei |
| spellingShingle |
Liu, Kai Ding, Lianggong Li, Yuhong Yang, Hui Zhao, Chunyue Lei, Ye Han, Shuting Tao, Wei Miao, Dengshun Steller, Hermann Welsh, Michael J. Liu, Lei Proceedings of the National Academy of Sciences Neuronal necrosis is regulated by a conserved chromatin-modifying cascade Multidisciplinary |
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liu, kai |
| spelling |
Liu, Kai Ding, Lianggong Li, Yuhong Yang, Hui Zhao, Chunyue Lei, Ye Han, Shuting Tao, Wei Miao, Dengshun Steller, Hermann Welsh, Michael J. Liu, Lei 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1413644111 <jats:title>Significance</jats:title> <jats:p> Neuronal necrosis widely occurs in devastating neurodegenerative diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease. However, it has long been considered a stochastic process lacking genetic regulations. Our inadequate understanding of its molecular mechanism has hindered pharmacological design to suppress this type of cell death. Through construction and studying of a <jats:italic>Drosophila</jats:italic> model of neuronal necrosis, we identified a chromatin-modifying cascade to play a key role in execution of neuronal necrosis. Our results indicate that neuronal necrosis is a stereotypically regulated process in both insect and mammalian neurons. This discovery provides previously unidentified biomarkers and potential therapeutic targets for neuronal necrosis. </jats:p> Neuronal necrosis is regulated by a conserved chromatin-modifying cascade Proceedings of the National Academy of Sciences |
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| title |
Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_unstemmed |
Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_full |
Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_fullStr |
Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_full_unstemmed |
Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_short |
Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_sort |
neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
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Multidisciplinary |
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http://dx.doi.org/10.1073/pnas.1413644111 |
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2014 |
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13960-13965 |
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<jats:title>Significance</jats:title>
<jats:p>
Neuronal necrosis widely occurs in devastating neurodegenerative diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease. However, it has long been considered a stochastic process lacking genetic regulations. Our inadequate understanding of its molecular mechanism has hindered pharmacological design to suppress this type of cell death. Through construction and studying of a
<jats:italic>Drosophila</jats:italic>
model of neuronal necrosis, we identified a chromatin-modifying cascade to play a key role in execution of neuronal necrosis. Our results indicate that neuronal necrosis is a stereotypically regulated process in both insect and mammalian neurons. This discovery provides previously unidentified biomarkers and potential therapeutic targets for neuronal necrosis.
</jats:p> |
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| author | Liu, Kai, Ding, Lianggong, Li, Yuhong, Yang, Hui, Zhao, Chunyue, Lei, Ye, Han, Shuting, Tao, Wei, Miao, Dengshun, Steller, Hermann, Welsh, Michael J., Liu, Lei |
| author_facet | Liu, Kai, Ding, Lianggong, Li, Yuhong, Yang, Hui, Zhao, Chunyue, Lei, Ye, Han, Shuting, Tao, Wei, Miao, Dengshun, Steller, Hermann, Welsh, Michael J., Liu, Lei, Liu, Kai, Ding, Lianggong, Li, Yuhong, Yang, Hui, Zhao, Chunyue, Lei, Ye, Han, Shuting, Tao, Wei, Miao, Dengshun, Steller, Hermann, Welsh, Michael J., Liu, Lei |
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| description | <jats:title>Significance</jats:title> <jats:p> Neuronal necrosis widely occurs in devastating neurodegenerative diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease. However, it has long been considered a stochastic process lacking genetic regulations. Our inadequate understanding of its molecular mechanism has hindered pharmacological design to suppress this type of cell death. Through construction and studying of a <jats:italic>Drosophila</jats:italic> model of neuronal necrosis, we identified a chromatin-modifying cascade to play a key role in execution of neuronal necrosis. Our results indicate that neuronal necrosis is a stereotypically regulated process in both insect and mammalian neurons. This discovery provides previously unidentified biomarkers and potential therapeutic targets for neuronal necrosis. </jats:p> |
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| spelling | Liu, Kai Ding, Lianggong Li, Yuhong Yang, Hui Zhao, Chunyue Lei, Ye Han, Shuting Tao, Wei Miao, Dengshun Steller, Hermann Welsh, Michael J. Liu, Lei 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1413644111 <jats:title>Significance</jats:title> <jats:p> Neuronal necrosis widely occurs in devastating neurodegenerative diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease. However, it has long been considered a stochastic process lacking genetic regulations. Our inadequate understanding of its molecular mechanism has hindered pharmacological design to suppress this type of cell death. Through construction and studying of a <jats:italic>Drosophila</jats:italic> model of neuronal necrosis, we identified a chromatin-modifying cascade to play a key role in execution of neuronal necrosis. Our results indicate that neuronal necrosis is a stereotypically regulated process in both insect and mammalian neurons. This discovery provides previously unidentified biomarkers and potential therapeutic targets for neuronal necrosis. </jats:p> Neuronal necrosis is regulated by a conserved chromatin-modifying cascade Proceedings of the National Academy of Sciences |
| spellingShingle | Liu, Kai, Ding, Lianggong, Li, Yuhong, Yang, Hui, Zhao, Chunyue, Lei, Ye, Han, Shuting, Tao, Wei, Miao, Dengshun, Steller, Hermann, Welsh, Michael J., Liu, Lei, Proceedings of the National Academy of Sciences, Neuronal necrosis is regulated by a conserved chromatin-modifying cascade, Multidisciplinary |
| title | Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_full | Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_fullStr | Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_full_unstemmed | Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_short | Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_sort | neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| title_unstemmed | Neuronal necrosis is regulated by a conserved chromatin-modifying cascade |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1413644111 |