Eintrag weiter verarbeiten
Determinants of cluster distribution in the molecular epidemiology of tuberculosis
Gespeichert in:
| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | |
| In: | Proceedings of the National Academy of Sciences, 99, 2002, 3, S. 1538-1543 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Murray, Megan Murray, Megan |
|---|---|
| author |
Murray, Megan |
| spellingShingle |
Murray, Megan Proceedings of the National Academy of Sciences Determinants of cluster distribution in the molecular epidemiology of tuberculosis Multidisciplinary |
| author_sort |
murray, megan |
| spelling |
Murray, Megan 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.022618299 <jats:p> Recently developed molecular techniques have revolutionized the epidemiology of tuberculosis. Multiple studies have used these tools to examine the population structure of <jats:italic>Mycobacterium tuberculosis</jats:italic> isolates in different communities. The distributions of clusters of <jats:italic>M. tuberculosis</jats:italic> isolates in these settings may variously reflect social mixing patterns or the differential fitness of specific clones of the organism. We developed an individual-based microsimulation of tuberculosis transmission to explore social and demographic determinants of cluster distribution and to observe the effect of transmission dynamics on the empiric data from molecular epidemiologic studies. Our results demonstrate that multiple host-related factors contribute to wide variation in cluster distributions even when all strains of the organism are assumed to be equally transmissible. These host characteristics include interventions such as chemotherapy, vaccination and chemoprophylaxis, HIV prevalence, the age structure of the population, and the prevalence of latent tuberculosis infection. We consider the implications of these results for the interpretation of cluster studies of <jats:italic>M. tuberculosis</jats:italic> as well as the more general application of microsimulation models to infectious disease epidemiology. </jats:p> Determinants of cluster distribution in the molecular epidemiology of tuberculosis Proceedings of the National Academy of Sciences |
| doi_str_mv |
10.1073/pnas.022618299 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjAyMjYxODI5OQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjAyMjYxODI5OQ |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Zwi2 |
| imprint |
Proceedings of the National Academy of Sciences, 2002 |
| imprint_str_mv |
Proceedings of the National Academy of Sciences, 2002 |
| issn |
0027-8424 1091-6490 |
| issn_str_mv |
0027-8424 1091-6490 |
| language |
English |
| mega_collection |
Proceedings of the National Academy of Sciences (CrossRef) |
| match_str |
murray2002determinantsofclusterdistributioninthemolecularepidemiologyoftuberculosis |
| publishDateSort |
2002 |
| publisher |
Proceedings of the National Academy of Sciences |
| recordtype |
ai |
| record_format |
ai |
| series |
Proceedings of the National Academy of Sciences |
| source_id |
49 |
| title |
Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_unstemmed |
Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_full |
Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_fullStr |
Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_full_unstemmed |
Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_short |
Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_sort |
determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.022618299 |
| publishDate |
2002 |
| physical |
1538-1543 |
| description |
<jats:p>
Recently developed molecular techniques have revolutionized the epidemiology of tuberculosis. Multiple studies have used these tools to examine the population structure of
<jats:italic>Mycobacterium tuberculosis</jats:italic>
isolates in different communities. The distributions of clusters of
<jats:italic>M. tuberculosis</jats:italic>
isolates in these settings may variously reflect social mixing patterns or the differential fitness of specific clones of the organism. We developed an individual-based microsimulation of tuberculosis transmission to explore social and demographic determinants of cluster distribution and to observe the effect of transmission dynamics on the empiric data from molecular epidemiologic studies. Our results demonstrate that multiple host-related factors contribute to wide variation in cluster distributions even when all strains of the organism are assumed to be equally transmissible. These host characteristics include interventions such as chemotherapy, vaccination and chemoprophylaxis, HIV prevalence, the age structure of the population, and the prevalence of latent tuberculosis infection. We consider the implications of these results for the interpretation of cluster studies of
<jats:italic>M. tuberculosis</jats:italic>
as well as the more general application of microsimulation models to infectious disease epidemiology.
</jats:p> |
| container_issue |
3 |
| container_start_page |
1538 |
| container_title |
Proceedings of the National Academy of Sciences |
| container_volume |
99 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792344193964703749 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:01:32.581Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Determinants+of+cluster+distribution+in+the+molecular+epidemiology+of+tuberculosis&rft.date=2002-02-05&genre=article&issn=1091-6490&volume=99&issue=3&spage=1538&epage=1543&pages=1538-1543&jtitle=Proceedings+of+the+National+Academy+of+Sciences&atitle=Determinants+of+cluster+distribution+in+the+molecular+epidemiology+of+tuberculosis&aulast=Murray&aufirst=Megan&rft_id=info%3Adoi%2F10.1073%2Fpnas.022618299&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792344193964703749 |
| author | Murray, Megan |
| author_facet | Murray, Megan, Murray, Megan |
| author_sort | murray, megan |
| container_issue | 3 |
| container_start_page | 1538 |
| container_title | Proceedings of the National Academy of Sciences |
| container_volume | 99 |
| description | <jats:p> Recently developed molecular techniques have revolutionized the epidemiology of tuberculosis. Multiple studies have used these tools to examine the population structure of <jats:italic>Mycobacterium tuberculosis</jats:italic> isolates in different communities. The distributions of clusters of <jats:italic>M. tuberculosis</jats:italic> isolates in these settings may variously reflect social mixing patterns or the differential fitness of specific clones of the organism. We developed an individual-based microsimulation of tuberculosis transmission to explore social and demographic determinants of cluster distribution and to observe the effect of transmission dynamics on the empiric data from molecular epidemiologic studies. Our results demonstrate that multiple host-related factors contribute to wide variation in cluster distributions even when all strains of the organism are assumed to be equally transmissible. These host characteristics include interventions such as chemotherapy, vaccination and chemoprophylaxis, HIV prevalence, the age structure of the population, and the prevalence of latent tuberculosis infection. We consider the implications of these results for the interpretation of cluster studies of <jats:italic>M. tuberculosis</jats:italic> as well as the more general application of microsimulation models to infectious disease epidemiology. </jats:p> |
| doi_str_mv | 10.1073/pnas.022618299 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjAyMjYxODI5OQ |
| imprint | Proceedings of the National Academy of Sciences, 2002 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 2002 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2 |
| issn | 0027-8424, 1091-6490 |
| issn_str_mv | 0027-8424, 1091-6490 |
| language | English |
| last_indexed | 2024-03-01T17:01:32.581Z |
| match_str | murray2002determinantsofclusterdistributioninthemolecularepidemiologyoftuberculosis |
| mega_collection | Proceedings of the National Academy of Sciences (CrossRef) |
| physical | 1538-1543 |
| publishDate | 2002 |
| publishDateSort | 2002 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | ai |
| recordtype | ai |
| series | Proceedings of the National Academy of Sciences |
| source_id | 49 |
| spelling | Murray, Megan 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.022618299 <jats:p> Recently developed molecular techniques have revolutionized the epidemiology of tuberculosis. Multiple studies have used these tools to examine the population structure of <jats:italic>Mycobacterium tuberculosis</jats:italic> isolates in different communities. The distributions of clusters of <jats:italic>M. tuberculosis</jats:italic> isolates in these settings may variously reflect social mixing patterns or the differential fitness of specific clones of the organism. We developed an individual-based microsimulation of tuberculosis transmission to explore social and demographic determinants of cluster distribution and to observe the effect of transmission dynamics on the empiric data from molecular epidemiologic studies. Our results demonstrate that multiple host-related factors contribute to wide variation in cluster distributions even when all strains of the organism are assumed to be equally transmissible. These host characteristics include interventions such as chemotherapy, vaccination and chemoprophylaxis, HIV prevalence, the age structure of the population, and the prevalence of latent tuberculosis infection. We consider the implications of these results for the interpretation of cluster studies of <jats:italic>M. tuberculosis</jats:italic> as well as the more general application of microsimulation models to infectious disease epidemiology. </jats:p> Determinants of cluster distribution in the molecular epidemiology of tuberculosis Proceedings of the National Academy of Sciences |
| spellingShingle | Murray, Megan, Proceedings of the National Academy of Sciences, Determinants of cluster distribution in the molecular epidemiology of tuberculosis, Multidisciplinary |
| title | Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_full | Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_fullStr | Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_full_unstemmed | Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_short | Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_sort | determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| title_unstemmed | Determinants of cluster distribution in the molecular epidemiology of tuberculosis |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.022618299 |