Eintrag weiter verarbeiten
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
Gespeichert in:
| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Proceedings of the National Academy of Sciences, 107, 2010, 6, S. 2669-2674 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Koo, Ja Wook Russo, Scott J. Ferguson, Deveroux Nestler, Eric J. Duman, Ronald S. Koo, Ja Wook Russo, Scott J. Ferguson, Deveroux Nestler, Eric J. Duman, Ronald S. |
|---|---|
| author |
Koo, Ja Wook Russo, Scott J. Ferguson, Deveroux Nestler, Eric J. Duman, Ronald S. |
| spellingShingle |
Koo, Ja Wook Russo, Scott J. Ferguson, Deveroux Nestler, Eric J. Duman, Ronald S. Proceedings of the National Academy of Sciences Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior Multidisciplinary |
| author_sort |
koo, ja wook |
| spelling |
Koo, Ja Wook Russo, Scott J. Ferguson, Deveroux Nestler, Eric J. Duman, Ronald S. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.0910658107 <jats:p>Proinflammatory cytokines, such as IL-1β, have been implicated in the cellular and behavioral effects of stress and in mood disorders, although the downstream signaling pathways underlying these effects have not been determined. In the present study, we demonstrate a critical role for NF-κB signaling in the actions of IL-1β and stress. Stress inhibition of neurogenesis in the adult hippocampus, which has been implicated in the prodepressive effects of stress, is blocked by administration of an inhibitor of NF-κB. Further analysis reveals that stress activates NF-κB signaling and decreases proliferation of neural stem-like cells but not early neural progenitor cells in the adult hippocampus. We also find that depressive-like behaviors caused by exposure to chronic stress are mediated by NF-κB signaling. Together, these data identify NF-κB signaling as a critical mediator of the antineurogenic and behavioral actions of stress and suggest previously undescribed therapeutical targets for depression.</jats:p> Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior Proceedings of the National Academy of Sciences |
| doi_str_mv |
10.1073/pnas.0910658107 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjA5MTA2NTgxMDc |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjA5MTA2NTgxMDc |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
Proceedings of the National Academy of Sciences, 2010 |
| imprint_str_mv |
Proceedings of the National Academy of Sciences, 2010 |
| issn |
0027-8424 1091-6490 |
| issn_str_mv |
0027-8424 1091-6490 |
| language |
English |
| mega_collection |
Proceedings of the National Academy of Sciences (CrossRef) |
| match_str |
koo2010nuclearfactorkbisacriticalmediatorofstressimpairedneurogenesisanddepressivebehavior |
| publishDateSort |
2010 |
| publisher |
Proceedings of the National Academy of Sciences |
| recordtype |
ai |
| record_format |
ai |
| series |
Proceedings of the National Academy of Sciences |
| source_id |
49 |
| title |
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_unstemmed |
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_full |
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_fullStr |
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_full_unstemmed |
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_short |
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_sort |
nuclear factor-κb is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.0910658107 |
| publishDate |
2010 |
| physical |
2669-2674 |
| description |
<jats:p>Proinflammatory cytokines, such as IL-1β, have been implicated in the cellular and behavioral effects of stress and in mood disorders, although the downstream signaling pathways underlying these effects have not been determined. In the present study, we demonstrate a critical role for NF-κB signaling in the actions of IL-1β and stress. Stress inhibition of neurogenesis in the adult hippocampus, which has been implicated in the prodepressive effects of stress, is blocked by administration of an inhibitor of NF-κB. Further analysis reveals that stress activates NF-κB signaling and decreases proliferation of neural stem-like cells but not early neural progenitor cells in the adult hippocampus. We also find that depressive-like behaviors caused by exposure to chronic stress are mediated by NF-κB signaling. Together, these data identify NF-κB signaling as a critical mediator of the antineurogenic and behavioral actions of stress and suggest previously undescribed therapeutical targets for depression.</jats:p> |
| container_issue |
6 |
| container_start_page |
2669 |
| container_title |
Proceedings of the National Academy of Sciences |
| container_volume |
107 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792347126725869570 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:49:48.378Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Nuclear+factor-%CE%BAB+is+a+critical+mediator+of+stress-impaired+neurogenesis+and+depressive+behavior&rft.date=2010-02-09&genre=article&issn=1091-6490&volume=107&issue=6&spage=2669&epage=2674&pages=2669-2674&jtitle=Proceedings+of+the+National+Academy+of+Sciences&atitle=Nuclear+factor-%CE%BAB+is+a+critical+mediator+of+stress-impaired+neurogenesis+and+depressive+behavior&aulast=Duman&aufirst=Ronald+S.&rft_id=info%3Adoi%2F10.1073%2Fpnas.0910658107&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792347126725869570 |
| author | Koo, Ja Wook, Russo, Scott J., Ferguson, Deveroux, Nestler, Eric J., Duman, Ronald S. |
| author_facet | Koo, Ja Wook, Russo, Scott J., Ferguson, Deveroux, Nestler, Eric J., Duman, Ronald S., Koo, Ja Wook, Russo, Scott J., Ferguson, Deveroux, Nestler, Eric J., Duman, Ronald S. |
| author_sort | koo, ja wook |
| container_issue | 6 |
| container_start_page | 2669 |
| container_title | Proceedings of the National Academy of Sciences |
| container_volume | 107 |
| description | <jats:p>Proinflammatory cytokines, such as IL-1β, have been implicated in the cellular and behavioral effects of stress and in mood disorders, although the downstream signaling pathways underlying these effects have not been determined. In the present study, we demonstrate a critical role for NF-κB signaling in the actions of IL-1β and stress. Stress inhibition of neurogenesis in the adult hippocampus, which has been implicated in the prodepressive effects of stress, is blocked by administration of an inhibitor of NF-κB. Further analysis reveals that stress activates NF-κB signaling and decreases proliferation of neural stem-like cells but not early neural progenitor cells in the adult hippocampus. We also find that depressive-like behaviors caused by exposure to chronic stress are mediated by NF-κB signaling. Together, these data identify NF-κB signaling as a critical mediator of the antineurogenic and behavioral actions of stress and suggest previously undescribed therapeutical targets for depression.</jats:p> |
| doi_str_mv | 10.1073/pnas.0910658107 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjA5MTA2NTgxMDc |
| imprint | Proceedings of the National Academy of Sciences, 2010 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 2010 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0027-8424, 1091-6490 |
| issn_str_mv | 0027-8424, 1091-6490 |
| language | English |
| last_indexed | 2024-03-01T17:49:48.378Z |
| match_str | koo2010nuclearfactorkbisacriticalmediatorofstressimpairedneurogenesisanddepressivebehavior |
| mega_collection | Proceedings of the National Academy of Sciences (CrossRef) |
| physical | 2669-2674 |
| publishDate | 2010 |
| publishDateSort | 2010 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | ai |
| recordtype | ai |
| series | Proceedings of the National Academy of Sciences |
| source_id | 49 |
| spelling | Koo, Ja Wook Russo, Scott J. Ferguson, Deveroux Nestler, Eric J. Duman, Ronald S. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.0910658107 <jats:p>Proinflammatory cytokines, such as IL-1β, have been implicated in the cellular and behavioral effects of stress and in mood disorders, although the downstream signaling pathways underlying these effects have not been determined. In the present study, we demonstrate a critical role for NF-κB signaling in the actions of IL-1β and stress. Stress inhibition of neurogenesis in the adult hippocampus, which has been implicated in the prodepressive effects of stress, is blocked by administration of an inhibitor of NF-κB. Further analysis reveals that stress activates NF-κB signaling and decreases proliferation of neural stem-like cells but not early neural progenitor cells in the adult hippocampus. We also find that depressive-like behaviors caused by exposure to chronic stress are mediated by NF-κB signaling. Together, these data identify NF-κB signaling as a critical mediator of the antineurogenic and behavioral actions of stress and suggest previously undescribed therapeutical targets for depression.</jats:p> Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior Proceedings of the National Academy of Sciences |
| spellingShingle | Koo, Ja Wook, Russo, Scott J., Ferguson, Deveroux, Nestler, Eric J., Duman, Ronald S., Proceedings of the National Academy of Sciences, Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior, Multidisciplinary |
| title | Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_full | Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_fullStr | Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_full_unstemmed | Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_short | Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_sort | nuclear factor-κb is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| title_unstemmed | Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.0910658107 |