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Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , |
| In: | Proceedings of the National Academy of Sciences, 98, 2001, 9, S. 5240-5245 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Karlin, Samuel Mrázek, Jan Karlin, Samuel Mrázek, Jan |
|---|---|
| author |
Karlin, Samuel Mrázek, Jan |
| spellingShingle |
Karlin, Samuel Mrázek, Jan Proceedings of the National Academy of Sciences Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage Multidisciplinary |
| author_sort |
karlin, samuel |
| spelling |
Karlin, Samuel Mrázek, Jan 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.081077598 <jats:p> Predicted highly expressed (PHX) and putative alien genes determined by codon usages are characterized in the genome of <jats:italic>Deinococcus radiodurans</jats:italic> (strain R1). <jats:italic>Deinococcus radiodurans</jats:italic> (DEIRA) can survive very high doses of ionizing radiation that are lethal to virtually all other organisms. It has been argued that DEIRA is endowed with enhanced repair systems that provide protection and stability. However, predicted expression levels of DNA repair proteins with the exception of RecA tend to be low and do not distinguish DEIRA from other prokaryotes. In this paper, the capability of DEIRA to resist extreme doses of ionizing and UV radiation is attributed to an unusually high number of PHX chaperone/degradation, protease, and detoxification genes. Explicitly, compared with all current complete prokaryotic genomes, DEIRA contains the greatest number of PHX detoxification and protease proteins. Other sources of environmental protection against severe conditions of UV radiation, desiccation, and thermal effects for DEIRA are the several S-layer (surface structure) PHX proteins. The top PHX gene of DEIRA is the multifunctional tricarboxylic acid (TCA) gene aconitase, which, apart from its role in respiration, also alerts the cell to oxidative damage. </jats:p> Predicted highly expressed and putative alien genes of <i>Deinococcus radiodurans</i> and implications for resistance to ionizing radiation damage Proceedings of the National Academy of Sciences |
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Proceedings of the National Academy of Sciences, 2001 |
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| title |
Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_unstemmed |
Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_full |
Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_fullStr |
Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_full_unstemmed |
Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_short |
Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_sort |
predicted highly expressed and putative alien genes of
<i>deinococcus radiodurans</i>
and implications for resistance to ionizing radiation damage |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.081077598 |
| publishDate |
2001 |
| physical |
5240-5245 |
| description |
<jats:p>
Predicted highly expressed (PHX) and putative alien genes
determined by codon usages are characterized in the genome of
<jats:italic>Deinococcus radiodurans</jats:italic>
(strain R1).
<jats:italic>Deinococcus
radiodurans</jats:italic>
(DEIRA) can survive very high doses of ionizing
radiation that are lethal to virtually all other organisms. It has been
argued that DEIRA is endowed with enhanced repair systems that provide
protection and stability. However, predicted expression levels of DNA
repair proteins with the exception of RecA tend to be low and do not
distinguish DEIRA from other prokaryotes. In this paper, the capability
of DEIRA to resist extreme doses of ionizing and UV radiation is
attributed to an unusually high number of PHX chaperone/degradation,
protease, and detoxification genes. Explicitly, compared with all
current complete prokaryotic genomes, DEIRA contains the greatest
number of PHX detoxification and protease proteins. Other sources of
environmental protection against severe conditions of UV radiation,
desiccation, and thermal effects for DEIRA are the several S-layer
(surface structure) PHX proteins. The top PHX gene of DEIRA is the
multifunctional tricarboxylic acid (TCA) gene aconitase, which, apart
from its role in respiration, also alerts the cell to oxidative damage.
</jats:p> |
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| author | Karlin, Samuel, Mrázek, Jan |
| author_facet | Karlin, Samuel, Mrázek, Jan, Karlin, Samuel, Mrázek, Jan |
| author_sort | karlin, samuel |
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| description | <jats:p> Predicted highly expressed (PHX) and putative alien genes determined by codon usages are characterized in the genome of <jats:italic>Deinococcus radiodurans</jats:italic> (strain R1). <jats:italic>Deinococcus radiodurans</jats:italic> (DEIRA) can survive very high doses of ionizing radiation that are lethal to virtually all other organisms. It has been argued that DEIRA is endowed with enhanced repair systems that provide protection and stability. However, predicted expression levels of DNA repair proteins with the exception of RecA tend to be low and do not distinguish DEIRA from other prokaryotes. In this paper, the capability of DEIRA to resist extreme doses of ionizing and UV radiation is attributed to an unusually high number of PHX chaperone/degradation, protease, and detoxification genes. Explicitly, compared with all current complete prokaryotic genomes, DEIRA contains the greatest number of PHX detoxification and protease proteins. Other sources of environmental protection against severe conditions of UV radiation, desiccation, and thermal effects for DEIRA are the several S-layer (surface structure) PHX proteins. The top PHX gene of DEIRA is the multifunctional tricarboxylic acid (TCA) gene aconitase, which, apart from its role in respiration, also alerts the cell to oxidative damage. </jats:p> |
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| spelling | Karlin, Samuel Mrázek, Jan 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.081077598 <jats:p> Predicted highly expressed (PHX) and putative alien genes determined by codon usages are characterized in the genome of <jats:italic>Deinococcus radiodurans</jats:italic> (strain R1). <jats:italic>Deinococcus radiodurans</jats:italic> (DEIRA) can survive very high doses of ionizing radiation that are lethal to virtually all other organisms. It has been argued that DEIRA is endowed with enhanced repair systems that provide protection and stability. However, predicted expression levels of DNA repair proteins with the exception of RecA tend to be low and do not distinguish DEIRA from other prokaryotes. In this paper, the capability of DEIRA to resist extreme doses of ionizing and UV radiation is attributed to an unusually high number of PHX chaperone/degradation, protease, and detoxification genes. Explicitly, compared with all current complete prokaryotic genomes, DEIRA contains the greatest number of PHX detoxification and protease proteins. Other sources of environmental protection against severe conditions of UV radiation, desiccation, and thermal effects for DEIRA are the several S-layer (surface structure) PHX proteins. The top PHX gene of DEIRA is the multifunctional tricarboxylic acid (TCA) gene aconitase, which, apart from its role in respiration, also alerts the cell to oxidative damage. </jats:p> Predicted highly expressed and putative alien genes of <i>Deinococcus radiodurans</i> and implications for resistance to ionizing radiation damage Proceedings of the National Academy of Sciences |
| spellingShingle | Karlin, Samuel, Mrázek, Jan, Proceedings of the National Academy of Sciences, Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage, Multidisciplinary |
| title | Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_full | Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_fullStr | Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_full_unstemmed | Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_short | Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| title_sort | predicted highly expressed and putative alien genes of <i>deinococcus radiodurans</i> and implications for resistance to ionizing radiation damage |
| title_unstemmed | Predicted highly expressed and putative alien genes of Deinococcus radiodurans and implications for resistance to ionizing radiation damage |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.081077598 |